Abstract: An enzymatic electrochemical-based sensor includes a substrate and a conductive layer formed from a dried water-miscible conductive ink. The water-miscible conductive ink used to form the conductive layer includes a conductive material, an enzyme, a mediator, and a binding agent and is formulated such that the water-miscible conductive ink is a water-miscible aqueous-based dispersion and the binding agent became operatively water-insoluble upon drying.

Abstract: A redox polymer for use in an electrochemical-based sensor includes a hydrophobic polymer backbone (e.g., a hydrophobic poly(methyl methacrylate) polymer backbone) and at least one hydrophilic polymer arm (such as a hydrophilic oligo(N-vinylpyrrolidinone) polymer arm) attached to the hydrophobic polymer backbone. The redox polymer also includes a plurality of redox mediators (e.g., ferrocene-based redox mediators) attached to the at least one hydrophilic polymer arm.

Abstract: The present invention provides pyrrolo[2,3-b]pyridine-4-yl amines pyrrolo[2,3-b]pyrimidin-4-yl amines that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.

Abstract: The present invention provides compounds that modulate the activity of Janus kinases and are useful in the treatment of diseases related to activity of Janus kinases including, for example, immune-related diseases and cancer.

Abstract: An object identification system includes a monitor and a plurality of transceivers that communicate over a common medium. The monitor includes a first transmitter, a first receiver, and a processor. Each transceiver includes a resonant circuit, a transmitter, a receiver, and an antenna coupled to the resonant circuit. The processor performs a method for performing transceiver communication that includes the steps of: (a) transmitting from the first transmitter a first frequency for a first duration; (b) after lapse of the first duration, receiving via the first receiver a response signal from at least one of the resonant circuits; (c) determining a second frequency from the received response signal; and (d) performing transceiver communication using the second frequency.

Abstract: Monitoring systems and protocols are disclosed that are flexible in mode operation and format depending on the environment in which they are used. Such monitoring systems and protocols are able to change their utilization automatically, or by received instruction to do so. A location detection system includes one or more low frequency transmitters, one or more radio frequency monitoring tags and one or more receiving devices. The low frequency transmitter transmits location identification information, such as the transmitter ID, to a tag in the vicinity of the transmission. The tag relays the transmitter ID using a higher frequency transmission sent from the tag to the receiver. Communication protocols are disclosed that enable deciphering of multiple tag transmissions starting simultaneously.

Abstract: A fusible conductive ink for use in manufacturing microfluidic analytical systems includes micronised powder containing platinum and carbon, poly(bisphenol A-co-epichlorohydrin)-glycidyl end capped polymer, and a solvent. In addition, the ratio of micronised powder to poly(bisphenol A-co-epichlorohydrin)-glycidyl end capped polymer is in the range of 3:1 to 1:3. The fusible conductive inks can be employed in the manufacturing of microfluidic systems to form electrodes, electrically conductive traces and/or electrically conductive contact pads.

Abstract: A method for manufacturing an analysis module with accessible electrically conductive contact pads includes forming an insulating substrate with an upper surface, a microchannel(s) within the upper surface, and electrically conductive contact pad(s) disposed on the upper surface. The method also includes producing a laminate layer with a bottom surface, electrode(s) on the laminate layer bottom surface, and electrically conductive trace(s) on the laminate layer bottom surface. The method further includes adhering the laminate layer to the insulating substrate such that a portion of the bottom surface of the laminate layer is adhered to a portion of the upper surface of the insulating substrate, each electrode is exposed to at least one microchannel; and each electrically conductive trace is electrically contacted to at least one electrically conductive contact pad.

Abstract: Ionic hydrophilic high molecular weight redox polymers for use in enzymatic electrochemical-based sensors include a hydrophilic polymer (such as a hydrophilic polymer backbone) with ionic portions (e.g., cationic monomers incorporated in the hydrophilic polymer backbone) and a plurality of attached redox mediators. The redox mediators can be, for example, covalently attached to the hydrophilic polymer in a pendant manner. An exemplary cationic hydrophilic high molecular weight redox polymer is synthesized by co-polymerization of a hydrophilic acrylamide monomer, [2-(acryloyloxy)ethyl]trimethyl ammonium chloride and vinyl ferrocene.

Abstract: A microfluidic analytical system for monitoring an analyte (such as glucose) in a fluid sample (e.g., blood or ISF) includes an analysis module and an electrical device (for example, a meter or power supply). The analysis module includes an insulating substrate and a microchannel(s) within the insulating substrate's upper surface. The analysis module also includes a conductive contact pad(s) disposed on the upper surface of the insulating substrate and an electrode(s), with the electrode(s) being disposed over the microchannel. In addition, the analysis module includes an electrically conductive trace(s) that electrically connects the electrode to at least one electrically conductive contact pad. The analysis module also has a laminate layer disposed over the electrode, the electrically conductive trace, the microchannel and a portion of the upper surface of the insulating substrate.

Abstract: An electrochemical-based sensor includes an electrode with at least one electrode surface, a film disposed on the electrode surface, and a dialysis membrane disposed on the film. The film includes a redox enzyme and a hydrophilic redox polymer (i.e., a polymer with an attached redox mediator(s)). In addition, the dialysis membrane serves to entrap the redox polymer and redox enzyme in the vicinity of the electrode. Such entrapment is accomplished by employing a redox enzyme and a hydrophilic redox polymer of a sufficiently high molecular weight that they do not pass through the dialysis membrane.

Abstract: A redox polymer for use in an electrochemical-based sensor includes a hydrophobic polymer backbone (e.g., a hydrophobic poly(methyl methacrylate) polymer backbone) and at least one hydrophilic polymer arm (such as a hydrophilic oligo(N-vinylpyrrolidinone) polymer arm) attached to the hydrophobic polymer backbone. The redox polymer also includes a plurality of redox mediators (e.g., ferrocene-based redox mediators) attached to the at least one hydrophilic polymer arm.

Abstract: A microfluidic analytical system for monitoring an analyte (for example, glucose) in a liquid sample (e.g., ISF) includes an analysis module with at least one micro-channel for receiving and transporting a liquid sample, at least one analyte sensor for measuring an analyte in the liquid sample and at least one position electrode. The analyte sensor(s) and position electrode(s) are in operative communication with the micro-channel. The microfluidic system also includes a meter configured for measuring an electrical characteristic (such as impedance or resistance) of the position electrode(s). Moreover, the measured electrical characteristic is dependent on the position of the liquid sample in the micro-channel that is in operative communication with the position electrode for which an electrical characteristic is measured.

Abstract: A radio frequency identification device includes a transceiver having a resonant circuit, a rectifier, a charge pump, a state machine, and a transmitter. The resonant circuit includes an antenna and has a resonant frequency. The rectifier is coupled to the resonant circuit to provide a rectified signal in response to energy from the antenna. The charge pump is enabled in response to the rectified signal to provide a first logic signal. The state machine provides a second logic signal in response to the first logic signal. The transmitter includes an amplifier coupled to the resonant circuit to form a Colpitts oscillator that is enabled by the second logic signal to transmit a response signal for identifying the radio frequency identification device.

Abstract: A network of secure servers, requiring no central entity to administer user identities or access permissions. Each autonomous server hosts a set of user accounts. Users may link to and access the accounts of all other users in the network. Resources in accounts are private, but users may grant each other partial permissions to them. Links and permissions are independent of the location of accounts, and are cryptographically authenticated. Users may migrate their account between servers without loosing accumulated permissions, or breaking links that others have to their account. The ability to grant permissions may be delegated to reflect complex organizational structures. A permission may be configured to unlock data in a multitude of accounts. The system will support applications that require secure information sharing across multiple organizational boundaries, and provides a distributed security model which is feasible to deploy as it is wholly administered by its users.

Abstract: A system for delivery of high dosage of radiation to a targeted spinal area is provided. This is accomplished by a system which provides for precise immobilization and positioning of the treated spinal area during dose planning and treatment via stereotactic radiosurgery. Advantages of the system include convenience to the patient, enhanced efficacy, and reduced risk of radiotoxicity to non-target tissues.

Abstract: A non-disruptive, on-line testing and switchover method and apparatus in a high availability, fibre channel switching environment. In a network having an active switching element, a redundant switching element and a port, one aspect of the present invention provides for verifying a working data path from the port to the redundant switching element, and thereafter verifying a working control path to the redundant switching element. Both verification tests take place without interrupting operation on the network. In addition, another aspect of the present invention provides for recognizing a failure occurrence in the active switching element, and thereafter switching to the redundant switching element with the potential for minimal frame loss.

Abstract: A method of enabling reuse of Web session data generated at a server in a client/server environment is described. The method comprises: recording a user's interaction with a Web site thereby producing Web session data; converting the Web session data into a document having a portable format; and transferring the portable format document to a user such that it may be reused to regenerate at least a part of the Web session at a later point in time. The portable document, typically in an XML format with XSL formatting instructions, can be passed to different users for editing and use by them and makes the Web session data browser and server independent.

Abstract: A non-disruptive, on-line testing and switchover method and apparatus in a high availability, fiber channel switching environment. In a network having an active switching element, a redundant switching element and a port, one aspect of the present invention provides for verifying a working data path from the port to the redundant switching element, and thereafter verifying a working control path to the redundant switching element. Both verification tests take place without interrupting operation on the network. In addition, another aspect of the present invention provides for recognizing a failure occurrence in the active switching element, and thereafter switching to the redundant switching element with the potential for minimal frame loss.

Abstract: A non-disruptive, on-line testing and switchover method and apparatus in a high availability, fibre channel switching environment. In a network having an active switching element, a redundant switching element and a port, one aspect of the present invention provides for verifying a working data path from the port to the redundant switching element, and thereafter verifying a working control path to the redundant switching element. Both verification tests take place without interrupting operation on the network. In addition, another aspect of the present invention provides for recognizing a failure occurrence in the active switching element, and thereafter switching to the redundant switching element with the potential for minimal frame loss.