Patents by Inventor James Roger Black

James Roger Black has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystal structure of FMS-like tyrosine kinase
    Patent number: 7494795
    Abstract: The invention relates to FMS-like tyrosine kinase (FLT3), FLT3 binding pockets or FLT3-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to FMS-like tyrosine kinase protein, complexes of FMS-like tyrosine kinase protein, homologues thereof, or FLT-3-like protein or protein complexes. The invention also relates to crystallizable compositions and crystals comprising an FMS-like tyrosine kinase cytoplasmic domain or homologues thereof. The invention also relates to methods of identifying inhibitors of the cytoplasmic domain of FMS-like tyrosine kinase protein.
    Type: Grant
    Filed: September 15, 2004
    Date of Patent: February 24, 2009
    Inventors: James Paul Griffith, James Roger Black, Carlos H. Faerman, Lovorka Lora Swenson, Michael Andrew Wynn, Fan Lu, Judith A. Lippke, Kumkum Saxena