Abstract: Surgical systems and methods are provided. The surgical systems include at least one primary surgical system, and an electronic management system in electronic communication with the primary surgical system. The electronic management system is configured to update a virtual compatibility list stored on a primary surgical system with compatibility information, create a first virtual kit for a surgical procedure, and provide the first virtual kit. The compatibility information characterizes a level of compatibility between the primary surgical system and one or more secondary surgical systems in electronic communication with the electronic management system. The first virtual kit including the primary surgical system and at least one of the one or more secondary surgical systems selected based upon the compatibility list.

Abstract: Surgical systems and methods are provided. The surgical systems include a manufacturer-sealed sterile surgical package containing a surgical instrument, at least one data processor, and memory storing instructions configured to cause the at least one data processor to perform operations. The operations include receive, from a remote server, data characterizing one or more aspects of a surgical procedure involving the surgical instrument, determine a level of compatibility of the surgical instrument with each of the one or more aspects of the surgical procedure, provide the determined level of compatibility.

Abstract: A system comprising a computer-readable storage medium storing at least one program, and a computer-implemented method for enhancing and personalizing an interactive marketplace. The systems and methods provided herein may allow a user to receive search results that are tailored to the user's personal preferences based on social and purchasing information known about the user. In addition, the systems and methods provided herein may provide shipping updates to a buyer that include a personalized message based on location information provided by the package being shipped. In addition, the systems and methods provided herein allow merchants to provide incentives and rewards for shoppers by participating in interactive shopping games.

Abstract: Bird's eye view (BEV) semantic mapping systems and methods are provided. A method includes receiving an image captured by a monocular camera having a first point of view (POV) of an environment including a plurality of features. The method further includes processing, by an artificial neural network (ANN), the captured image to generate a semantic map for the captured image, the semantic map associated with a second POV different from the first POV. The features exhibit a uniform scale in the semantic map. Additional methods and associated systems are also provided.

Abstract: A system with an interactive user interface for users to view and interact with sanitized log data received from a plurality of hosts, such as those associated with various services of an organization. The system may receive from hosts log files and/or metadata that have been filtered by agents executing on the respective hosts to remove or anonymize any sensitive or confidential information prior to transmission to the system. In some embodiments the system does further filtering of the sanitized data. Received sanitized data is parsed, indexed, and/or otherwise processed for optimal searching, and stored in a log pipeline. The system causes display of an electronic visualization interface.

Abstract: A system comprising a computer-readable storage medium storing at least one program, and a computer-implemented method for enhancing and personalizing an interactive marketplace. The systems and methods provided herein may allow a user to receive search results that are tailored to the user's personal preferences based on social and purchasing information known about the user. In addition, the systems and methods provided herein may provide shipping updates to a buyer that include a personalized message based on location information provided by the package being shipped. In addition, the systems and methods provided herein allow merchants to provide incentives and rewards for shoppers by participating in interactive shopping games.

Abstract: A composition for stabilising one or more unstable bioactive components, the formulation comprising a protective matrix of at least agar and glycerol; and a bioactive component at 0.005-15% w/w embedded in the matrix, an animal chew for veterinary use comprising said composition and a process of making the same.

Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of CCR4 activity.

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

Abstract: Described are various embodiments of a digital data comparison filter, system and method, and applications therefor. In one embodiment, a digital data comparator system comprises two or more transformation engines each having securely stored in association therewith a common key, a common designated comparator threshold number, and a respective identifier; and a reconstitution engine operable to access partial encryption information from each transformation engine and, only upon relating to identical digital data, process each partial encryption information to successfully release the identical digital data.

Abstract: Described are various embodiments of an integrated network appliance and system. In one embodiment, the appliance comprises: a hardware-integrated processing engine operable to implement a trusted network-related resource; an integrated digital data processor operable to execute said processing engine; an integrated data storage resource accessible to said processing engine to implement said trusted network-related resource; an integrated location sensor; and an embedded hardware security module (HSM) hardwired to interface with said hardware-integrated processing engine via a dedicated hardware-isolated communication path, and operable to execute a trusted internal cryptographic process associated with said trusted network-related resource as a function of location data output from said integrated location sensor.

Abstract: Systems, methods, and instrumentalities are described herein for autonomous operation of a surgical device within a predefined boundary. A discrete signal associated with clamping control (e.g., closure of a clamping jaw) may be received by the surgical device. The discrete signal may be triggered by a healthcare professional or autonomously activated. The surgical device, in response to the discrete signal and based on an algorithm, may generate a continuous signal to cause a continuous application of force or deployment of an operation. The surgical device, based at least on a measurement associated with one of tissue, inrush current, or the distance between the smart energy device and the smart grasper may determine a safety adjustment associated with the operation of the surgical device.

Abstract: A computing system may receive first operation data associated with a first surgical procedure and second operation data associated with a second surgical procedure. The computing system receive first outcome data associated with the first surgical procedure and second outcome data associated with the second surgical procedure. The computing system determine that each of the control algorithm of the first surgical device and the control algorithm of the second surgical device is an up-to-date control algorithm associated with the first surgical device type. The computing system generate first aggregation data based on at least the first operation data, the second operation data, the first outcome data, and the second outcome data. Based on the first aggregation data, the computing system determine a correlation between a first aspect of the up-to-date control algorithm and outcome data. Based on the determined correlation, the computing system generate an updated up-to-date control algorithm.

Abstract: Systems, methods, and instrumentalities are disclosed for aggregating patient, procedure, surgeon, and/or facility pre-surgical data and population and adaptation of a starting procedure plan template. Pre-surgical data may be used to populate a patient specific surgical procedure plan. A surgical system (e.g., surgical hub) may be configured to obtain patient specific pre-surgical data for a patient specific surgical procedure. The surgical system may obtain a surgical procedure template comprising surgical procedure steps. The surgical system may determine surgical task options for the surgical procedure steps, for example, based on the patient specific pre-surgical data. The surgical system may determine characterizations (e.g., predicted outcomes, risk levels, efficiency) for the surgical task options. A populated patient specific procedure plan may be generated, for example, which may include the determined surgical procedure steps and the respective characterizations.

Abstract: Examples described herein may include a surgical computing system that determines an autonomous operation parameter and generates a control signal for an autonomous operation based on the autonomous operation parameter. The surgical computing system may obtain surgical data and determine the autonomous operation parameter based on the surgical data. The surgical computing system may obtain surgical data and determine the autonomous operation parameter based on the surgical data. The surgical computing system may send the control signal for the autonomous operation, for example, to one or more smart surgical devices.

Abstract: Systems, methods, and instrumentalities may be described herein for automating a surgical task. The device may receive an indication of a surgical task to be performed with a surgical instrument. Capabilities of the surgical instrument may be associated with levels of automation. The device may monitor a performance of the surgical task with the surgical instrument operating at a first level of automation associated with the levels of automation. The device may detect a trigger event associated with the performance of the surgical task and switch operation of the surgical instrument from the first level of automation to a second level of automation associated with levels of automation, for example, based on the trigger event.

Abstract: Systems, methods, and instrumentalities are described herein for detecting failure mitigation associated with a surgical task. A device may perform a first autonomous function associated with a surgical task. Performing the first autonomous function may be associated with control feedback. The first autonomous function may be monitored by tracking one or more outputs associated with the control feedback. If the one or more outputs cross a failure threshold, the device may switch from performing the first autonomous function to performing a second autonomous function associated with the surgical task. The second autonomous function may be associated with failure mitigation feedback.

Abstract: Systems, methods, and instrumentalities are described herein for adapted autonomy functions and system interconnections. A surgical hub may detect a first surgical device in the surgical environment. The first surgical device may include a first plurality of features. The surgical hub may include a plurality of resources. The surgical hub may detect a second surgical device in the surgical environment. The second surgical device may include a second plurality of features. The surgical hub may determine one or more features from the first plurality of features for the first surgical device to perform and one or more features from the second plurality of features for the second surgical device to perform based on the plurality of resources.

Abstract: Described are various embodiments of a hardware security module, hardwired port interconnection matrix, and embedded communication channel resources operable on selected hardware port-specific data communicated via this matrix.