Abstract: A system comprising a computer-readable storage medium storing at least one program, and a computer-implemented method for enhancing and personalizing an interactive marketplace. The systems and methods provided herein may allow a user to receive search results that are tailored to the user's personal preferences based on social and purchasing information known about the user. In addition, the systems and methods provided herein may provide shipping updates to a buyer that include a personalized message based on location information provided by the package being shipped. In addition, the systems and methods provided herein allow merchants to provide incentives and rewards for shoppers by participating in interactive shopping games.

Abstract: A method and apparatus for a commerce platform coordinating a purchase of a product sold by a merchant system through a third party application are described. The method may include receiving a notification from the third party application requesting to purchase a product from within the third party application, wherein the notification comprises an identifier for the product and an identifier for the merchant system that sells the product. The method may also include a product checkout interface having an appearance consistent with an appearance of a user interface of the third party application, and transmitting the product checkout interface generated by the commerce platform to a user device executing the third party application causing the third party application to render the product checkout interface within at least a portion of the user interface of the third party application.

Abstract: Novel mutant ESR1 molecules and uses are disclosed.

Abstract: A security device for reinforcing a structure such as a door against cutting or other forms of attack, comprises a hollow casing with an interior space, and first and second rod assemblies positioned in the interior space under compression. The first rod assembly comprises a first rod and a first spring, and the second rod assembly comprises a second rod and a second spring. The first and second rod assemblies are parallel, and the first and second springs do not overlap. The first and second rods only have point contact with the casing.

Abstract: An improved system described herein equipped with one or more Pulsed Field Electroporation (PFE) electrodes configured to cause localized and targeted PFE output at the targeted tissue, for example, in an ear, nose, or throat.

Abstract: Instrument and systems for applying ablative energy to epicardial tissue via a subxiphoid access surgical approach. The instrument has a head assembly sized and shaped for a subxiphoid surgical approach to a patient's heart and defines a contact face. The head assembly includes a paddle body, a first ablation electrode, and a second ablation electrode. The ablation electrodes are coupled to the paddle body in a spaced apart, spatially-fixed fashion. The ablation electrodes are exteriorly exposed at the contact face. A tubular member extends from the head assembly and maintains wiring connected to the ablation electrodes. The instrument is manipulable to locate the contact face on epicardial tissue of a patient's heart via a subxiphoid surgical approach, such as between the left and right pulmonary vein junctions of the posterior left atrium.

Abstract: An improved system described herein equipped with one or more Pulsed Field Electroporation (PFE) electrodes configured to cause localized and targeted PFE output at the targeted tissue, for example, in an ear, nose, or throat.

Abstract: A composition for stabilising one or more unstable bioactive components, the formulation comprising a protective matrix of at least agar and glycerol; and a bioactive component at 0.005-15% w/w embedded in the matrix, an animal chew for veterinary use comprising said composition and a process of making the same.

Abstract: Disclosed herein, inter alia, are compounds and methods of use thereof for the modulation of CCR4 activity.

Abstract: Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided.

Abstract: Described are various embodiments of a digital data comparison filter, system and method, and applications therefor. In one embodiment, a digital data comparator system comprises two or more transformation engines each having securely stored in association therewith a common key, a common designated comparator threshold number, and a respective identifier; and a reconstitution engine operable to access partial encryption information from each transformation engine and, only upon relating to identical digital data, process each partial encryption information to successfully release the identical digital data.

Abstract: The disclosure is directed to improved methods for preparing substituted quinolinylcyclohexylpropanamide compounds.

Abstract: Described are various embodiments of an integrated network appliance and system. In one embodiment, the appliance comprises: a hardware-integrated processing engine operable to implement a trusted network-related resource; an integrated digital data processor operable to execute said processing engine; an integrated data storage resource accessible to said processing engine to implement said trusted network-related resource; an integrated location sensor; and an embedded hardware security module (HSM) hardwired to interface with said hardware-integrated processing engine via a dedicated hardware-isolated communication path, and operable to execute a trusted internal cryptographic process associated with said trusted network-related resource as a function of location data output from said integrated location sensor.

Abstract: Systems, methods, and instrumentalities are described herein for autonomous operation of a surgical device within a predefined boundary. A discrete signal associated with clamping control (e.g., closure of a clamping jaw) may be received by the surgical device. The discrete signal may be triggered by a healthcare professional or autonomously activated. The surgical device, in response to the discrete signal and based on an algorithm, may generate a continuous signal to cause a continuous application of force or deployment of an operation. The surgical device, based at least on a measurement associated with one of tissue, inrush current, or the distance between the smart energy device and the smart grasper may determine a safety adjustment associated with the operation of the surgical device.

Abstract: A computing system may receive first operation data associated with a first surgical procedure and second operation data associated with a second surgical procedure. The computing system receive first outcome data associated with the first surgical procedure and second outcome data associated with the second surgical procedure. The computing system determine that each of the control algorithm of the first surgical device and the control algorithm of the second surgical device is an up-to-date control algorithm associated with the first surgical device type. The computing system generate first aggregation data based on at least the first operation data, the second operation data, the first outcome data, and the second outcome data. Based on the first aggregation data, the computing system determine a correlation between a first aspect of the up-to-date control algorithm and outcome data. Based on the determined correlation, the computing system generate an updated up-to-date control algorithm.

Abstract: Examples described herein may include a surgical computing system that determines an autonomous operation parameter and generates a control signal for an autonomous operation based on the autonomous operation parameter. The surgical computing system may obtain surgical data and determine the autonomous operation parameter based on the surgical data. The surgical computing system may obtain surgical data and determine the autonomous operation parameter based on the surgical data. The surgical computing system may send the control signal for the autonomous operation, for example, to one or more smart surgical devices.

Abstract: Systems, methods, and instrumentalities may be described herein for automating a surgical task. The device may receive an indication of a surgical task to be performed with a surgical instrument. Capabilities of the surgical instrument may be associated with levels of automation. The device may monitor a performance of the surgical task with the surgical instrument operating at a first level of automation associated with the levels of automation. The device may detect a trigger event associated with the performance of the surgical task and switch operation of the surgical instrument from the first level of automation to a second level of automation associated with levels of automation, for example, based on the trigger event.

Abstract: Systems, methods, and instrumentalities are described herein for adapted autonomy functions and system interconnections. A surgical hub may detect a first surgical device in the surgical environment. The first surgical device may include a first plurality of features. The surgical hub may include a plurality of resources. The surgical hub may detect a second surgical device in the surgical environment. The second surgical device may include a second plurality of features. The surgical hub may determine one or more features from the first plurality of features for the first surgical device to perform and one or more features from the second plurality of features for the second surgical device to perform based on the plurality of resources.

Abstract: Systems, methods, and instrumentalities are described herein for detecting failure mitigation associated with a surgical task. A device may perform a first autonomous function associated with a surgical task. Performing the first autonomous function may be associated with control feedback. The first autonomous function may be monitored by tracking one or more outputs associated with the control feedback. If the one or more outputs cross a failure threshold, the device may switch from performing the first autonomous function to performing a second autonomous function associated with the surgical task. The second autonomous function may be associated with failure mitigation feedback.