Abstract: There is provided a combined two-part intervertebral implant configured to restore the spacing between adjacent vertebrae. The implant generally includes a spacer ring having upper and lower vertebral engaging surfaces and a bore for receipt of a locking element. The implant further includes a locking element which is engagable within the spacer ring and has a diameter or height greater than the thickness of the spacer ring. In one embodiment, the spacer ring may be formed as a C-shaped element. In an alternative embodiment, the spacer ring may be formed as an intact ring having a side bore for receipt of the locking element. One or both parts of the implant may be partially or wholly surface demineralized to provide a flexible surface on implant. A method of using the spacer ring and locking element to secure the assembled implant between adjacent vertebrae is also disclosed.

Abstract: The subject-matter of the present invention is a process of use in perfluoroalkylation and a reactant for making use of this process. This process is defined in that it comprises a stage in which a material of formula RfH and a base (or a species capable of generating a base) are brought into contact, in a polar and anhydrous medium, with a substrate carrying at least one electrophilic functional group. Application to organic synthesis.

Abstract: The subject-matter of the present invention is a process of use in perfluoroalkylation and a reactant for making use of this process. This process is defined in that it comprises a stage in which a material of formula RfH and a base (or a species capable of generating a base) are brought into contact, in a polar and anhydrous medium, with a substrate carrying at least one electrophilic functional group. Application to organic synthesis.