Abstract: This document provides methods and materials related to vesicular stomatitis viruses. For example, vesicular stomatitis viruses, nucleic acid molecules encoding VSV polypeptides, methods for making vesicular stomatitis viruses, and methods for using vesicular stomatitis viruses to treat cancer are provided.

Abstract: An injection system is described that receives, from one or more sensors, a first group of one or more signals indicating a current volume of injection fluid dispensed from a fluid reservoir at a first time. The injection system determines, based on the first group of one or more signals, that a difference between a dispensed volume limit and the current volume of the injection fluid dispensed from the fluid reservoir at the first time is less than a necessary volume of fluid required to complete both a systolic injection phase and a diastolic injection phase. The injection system further, responsive to determining that the difference is less than the necessary volume of fluid required to complete both the systolic injection phase and the diastolic injection phase, controls the injection system to refrain from performing each of the systolic injection phase and the diastolic injection phase.

Abstract: The present invention provides combination therapy that includes an KRASG12C inhibitor, such as or a pharmaceutically acceptable salt thereof, and one or more additional pharmaceutically active agents, particularly for the treatment of cancers. The invention also relates to pharmaceutical compositions that contain an KRASG12C inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.

Abstract: A method at a network element within a Vehicle to Everything (V2X) Communications Domain, the method including receiving a tracking request at the network element for a target vehicle, the tracking request including identifying information for the target vehicle; creating a target vehicle list based on the tracking request; distributing the target vehicle list to at least one V2X endpoint; receiving at least one sighting report from the at least one V2X endpoint; and forwarding the at least one sighting report to a second network element.

Abstract: A communication system and method for supporting a plurality of vehicle-to-everything radio access technologies (V2X RATs) is provided. The communication system configured to support multiple V2X RATs transmits, using a first V2X RAT, an indication of its availability to support an interworking function between the plurality of V2X RATs. The communication system receives an instruction to provide the interworking function between different V2X RATs. The interworking function may be incorporated in a vehicle that is joined to a platoon configured to use a first V2X RAT, and provide the interworking function between the first and a second V2X RAT. The interworking function may be used to add further vehicles to the platoon that communicate using only the second V2X RAT.

Abstract: Devices that includes a first portion, the first portion including at least one fluid channel; a fluid actuator; an analysis sensor disposed within the fluid channel; a conductivity sensor disposed within the fluid channel; and an introducer; a second portion, the second portion comprising: at least one well, the well containing at least one material, wherein one of the first or second portion is moveable with respect to the other, wherein the introducer is configured to obtain at least a portion of the material from the at least one well and deliver it to the fluid channel, and wherein the fluid actuator is configured to move at least a portion of the material in the fluid channel.

Abstract: Embodiments for protecting low-pressure blood pressure sensors in high-pressure fluid flow applications by equalizing pressure on both sides of a pressure sensor's diaphragm during high pressure are disclosed. A sensor protection device may include a pressure sensor assembly, a housing, and a plunger assembly. During low pressure, fluid in the primary flow path can flow through the housing, transferring its pressure to a first side of the diaphragm; the plunger assembly can prevent fluid flow into a secondary flow path in the housing, transferring atmospheric pressure to a second side of the diaphragm. During high pressure, fluid can still flow through the primary flow path, and the plunger assembly may now allow fluid flow into the secondary flow path, transferring pressure from the same fluid to the second side of the diaphragm to equal pressure across the diaphragm. The plunger assembly may automatically transition between low- and high-pressure configurations.

Abstract: There is provided a method of treating an inflammatory response to infection and complications associated therewith, by administering a proprotein convertase subtilisin kexin 9 (PCSK9) inhibitor to a subject, in need thereof. There is also provided a method of treating or preventing renal failure; renal dysfunction; respiratory failure; respiratory dysfunction; or acute lung injury. Provided herein are uses, pharmaceutical compositions, and commercial packages associated therewith.

Abstract: A method, computer program product and a user equipment (UE) are provided for assisting a user equipment (UE) in selecting a network function. A first message is received from the UE. The first message includes UE request capabilities. A second message is sent to the UE. The second message includes an indication that promotes the UE attempting to connect to a particular Public Land Mobile Network (PLMN) using a network function belonging to the particular PLMN.

Abstract: Disclosed sensors can include at least one resonator (in some embodiments, at least two resonators) and various other structures that may be formed in association with the resonators. The at least one resonator in embodiments can include a bottom electrode, a piezoelectric layer, and a top electrode, wherein the piezoelectric layer is positioned between the bottom electrode and the top electrode.

Abstract: Access devices may receive signals over a network and calculate a frequency spectrum of the received signals. An analyzer system may collect the frequency spectrum data from multiple access devices, and based on the collected data, detect, identify, and locate sources of anomalies in a communication network.

Abstract: Provided herein are methods of administering a KRAS G12C inhibitor to a cancer subject.

Abstract: Methods, systems, and devices supporting querying disparate data sources are described. Querying disparate data sources may include receiving an input for data stored at a first data source from a plurality of data sources, selecting a first data connector from a plurality of data connectors, wherein the first data connector corresponds to the first data source, and identifying a first query language corresponding to the first data source from a plurality of query languages. Querying the disparate data sources may further include generating a converted query based at least in part on the first query language and retrieving the data from the first data source using the first data connector based at least in part on the converted query.

Abstract: The present disclosure relates to quality control for point-of-care medical diagnostic systems. In various embodiments, the system includes an on-board storage containing a synthetic quality control material, a plurality of sub-systems having a plurality of operating parameters and including a material analyzer, a database storing quality control results that include results of the material analyzer analyzing the synthetic quality control material over time, one or more processors, and at least one memory storing instructions which, when executed by the one or more processors, cause the system to, automatically without user intervention: generate a control chart based on the quality control results, determine that a parameter of the plurality of operating parameters is out-of-tolerance based on the control chart, and adjust at least one of the plurality of sub-systems without user intervention to bring the out-of-tolerance parameter to within tolerance.

Abstract: A communication system and method for supporting a plurality of vehicle-to-everything radio access technologies (V2X RATs) is provided. The communication system configured to support multiple V2X RATs transmits, using a first V2X RAT, an indication of its availability to support an interworking function between the plurality of V2X RATs. The communication system receives an instruction to provide the interworking function between different V2X RATs. The interworking function may be incorporated in a vehicle that is joined to a platoon configured to use a first V2X RAT, and provide the interworking function between the first and a second V2X RAT. The interworking function may be used to add further vehicles to the platoon that communicate using only the second V2X RAT.

Abstract: A device and a method of using the device for determining hematocrit in a whole blood sample. The device includes a first portion having an introducer, at least one fluid channel, a fluid actuator, and an analysis sensor and conductivity sensor disposed within the fluid channel. The second portion includes at least one well containing at least one material. The first portion and second portion are movable with respect to each other. The introducer is configured to transfer at least a portion of the material from the well in portion two into the fluid channel of portion one. The method includes measuring the resistance over substantially the entire portion of a whole blood sample and calculating an average hematocrit level of the whole blood sample based on the measured resistance.

Abstract: An organ perfusion system comprises: a perfusion fluid circuit (16) arranged to circulate perfusion fluid through the organ; a surrogate organ (126) arranged to be connected into the circuit in place of the organ so that the circuit can circulate fluid through the surrogate organ; and organ sensing means arranged to distinguish between the presence of the organ in the circuit and the presence of the surrogate organ in the circuit. The sensing means may comprise one or more pressure sensors (136, 137, 138), or a flow meter (125). Further aspects relate to adjusting the content of at least one component, such as oxygen or a nutrient, in the perfusion fluid. Bubble detection means (113), and means (74) to measure the amount of fluid secreted by or leaked from the organ, may also be provided.

Abstract: Provided are an artificial intelligence (AI) system simulating a function of a human brain, such as cognition and judgment, using a machine learning algorithm, such as deep learning, and an application thereof. Also, provided is a method, performed by an electronic apparatus, of refining an artificial intelligence (AI) model, the method including: detecting information about a context of an electronic apparatus used to refine a local model stored in the electronic apparatus being changed; determining a gradient for refining the local model based on the changed information about the context; refining the local model based on the determined gradient; transmitting the gradient to a server; receiving, from the server, information about a global model refined based on the gradient; and refining the local model based on the received information.

Abstract: This document relates to materials and methods for treating cancer. For example, this document provides materials and methods for using PD-L1 targeting domains in bispecific chimeric polypeptides, chimeric transmembrane polypeptides, genetically modified viruses, nucleic acid vectors, and/or fusion-inducing cells to treat cancer.

Abstract: Disclosed herein are systems, methods, and device for performing external counterpulsation. The external counterpulsation device can include a cuff including a body, a first end, and a second end. In some examples, the external counterpulsation device includes a removable tubular connector, a removably attached bladder, and a securing material extending across a length of the body of the cuff. The external counterpulsation device also includes a u-shaped buckle having a first arm, a second arm, and an opening. The first arm is configured to extend through the opening of the first end of the cuff and the second arm is configured to form a roller. The opening of the buckle is formed between the first arm and the second arm and is configured to allow the body of the cuff to extend through the u-shaped buckle.