Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.

Abstract: Disclosed herein, inter alia, are nucleotide analogues, and methods of use thereof, having cleavable orthogonal linkers.

Abstract: Disclosed herein, inter alia, are nucleotide analogues, and methods of use thereof, having cleavable orthogonal linkers.

Abstract: Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof in the sequencing a nucleic acid.

Abstract: A computer-implemented method and system provide point of care processing of an insurance claim relating to oral care delivered to a subject patient during a visit of the patient to a dental clinic. The method includes processing, by a computer system, of dental image data and patient data, using a set of machine learning models, to extract output representative of diagnostic data characterizing the dental image data; determining, by a decision support system a claim decision based on the diagnostic data; and communicating the claim decision in real time to an endpoint located in the dental clinic.

Abstract: The invention provides various orthogonal nucleotide analogues and methods for using combinations of said various orthogonal nucleotide analogues for sequencing by synthesis.

Abstract: The invention provides nucleotide analogues and methods of use thereof for sequencing by synthesis using energy transfer dye pairs.

Abstract: Disclosed herein are highly accurate approaches for single molecule electronic nanopore-based SBS.

Abstract: Disclosed herein, inter alia, are nucleotide analogues, and methods of use thereof, having cleavable orthogonal linkers.

Abstract: A combustor assembly for a gas turbine engine includes a dome and a deflector positioned adjacent to the dome. One or both of the dome and the deflector define an opening, a component axis extending through the opening, and a radial direction relative to the component axis. The combustor assembly also includes a retainer having an outer member contacting the dome, the deflector or both. The outer member of the retainer defines at least in part a retainer cavity inward of the outer member along the radial direction. The dome, the deflector, or both define a plurality of cooling holes for providing a cooling airflow from the retainer cavity to the opening.

Abstract: A combustor assembly for a gas turbine engine includes a dome and a deflector positioned adjacent to the dome. One or both of the dome and the deflector define an opening, a component axis extending through the opening, and a radial direction relative to the component axis. The combustor assembly also includes a retainer having an outer member contacting the dome, the deflector or both. The outer member of the retainer defines at least in part a retainer cavity inward of the outer member along the radial direction. The dome, the deflector, or both define a plurality of cooling holes for providing a cooling airflow from the retainer cavity to the opening.

Abstract: A stored program pay-per-play system includes a high-capacity storage medium facilitating compilation of video, audio or other programs at a subscriber's site. While the recording of such programs may take place at any time preceding playback, billing occurs only when, and if, the subscriber chooses to select a program for replay or actually enjoys the program substantially in its entirety. Billing is alternatively based on a store-credit or account debiting scheme. The recording of program materials may be directed automatically by subscriber-operated storage management facilities which scan program schedules and select materials to be recorded, based on title, cast, program genre or any other of a variety of viewer/listener preferences. Alternatively, the program provider may automatically download programs, either based upon actual or surmised viewer preferences, or at the provider's discretion, for example, using newly-available selections.

Abstract: A system includes a hardware platform, at least one driver, a plurality of devices connected to the hardware platform, a middleware interface, and a plurality of software services. Each of the plurality of devices is selected from the group consisting of sensors and actuators. The plurality of software services is generated by the at least one driver, wherein a software service associates with a device, and wherein each of the software services complies with the middleware interface. A method for interfacing a plurality of devices to a hardware platform includes communicably connecting each of the plurality of devices to the hardware platform, converting each of the plurality of devices into a programmable software service using a driver, and programming each of the software services to comply with a middleware interface.

Abstract: This invention provides a combinatorial fluorescence energy transfer tag which comprises a plurality of fluorescent molecules, comprising one or more energy transfer donor and one or more energy transfer acceptor, linked through a molecular scaffold wherein the fluorescent molecules are separated along the scaffold to produce a unique fluorescene emission signature. The invention further provides for the use of said tags in multi-component analyses, including multiplex biological analyses.

Abstract: An automated punching arrangement for punching successive sheets or lifts from an input stack of sheets, and arranging those sheets in an output stack. The automated punching arrangement receives the stack at an input platform that automatically advances the stack into the machine where a picker picks a sheet or successive lifts from the stack and delivers them along an input path into direct registration in a die set. Punched sheets are advanced out of the punch at a 90° angle from the input path along an output path, and inverted by an inverter to the output stack on an output platform. The punched stack of sheets is then advanced out of the machine. The machine includes automated set up including reading of dedicated identifying markers on die sets and resulting adjustment of the die set position within the machine and of the back plate within the die set.

Abstract: A punching station that utilizes low cost, interchangeable, linearly operating die sets, and may be disposed in line with a printer to punch individual sheets as they proceed through the printer. Sheets exiting a printer or other machine are rapidly accelerated along a circuitous path in the punching station, and then into position between the die plates of a linearly actuated die. The sheet is stopped and punched, and then rapidly accelerated out of the punch to exit the punching station. Each sheet is accelerated to a speed that is typically greater than the speed of the sheet as it exits the printer. Die sets having different pin sizes and configurations are interchangeable within the punching station in order to permit rapid die changes, and the die pins are preferably made of powdered metal to yield low cost die sets.

Abstract: A sheet or sheet stack handling system for performing at least one operation on successive sheets or stacks of sheets, and interface for the same, wherein the document handling system includes at least two modules selected from a group consisting of an elevator transfer station, a modular transfer station, a storage station, a transportation cart, and a modular processing station. When more than one modular processing station are coupled to form the document handling system, the system may be utilized to perform a series of operations on successive sheets or stacks of sheets. Alternately, the individual processing stations or a group of the processing stations may be utilized to perform only certain functions on the sheets. The modules each contain a plurality of parallel, spaced, elongated support surfaces that form a sheet support surface.

Abstract: A set feeding apparatus (10) separates an uppermost set of paper sheets from a staggered stack of sets (36) with a platform (34) that biases the stack toward a carriage (42) that is moveable with respect to the stack. The carriage includes a cam-activated pic and a knife head that combine to raise the uppermost set from the stack. A plow then engages the raised portion of the uppermost set to move the set off of the stack.

Abstract: A stored program pay-per-play system includes a high-capacity storage medium facilitating compilation of video, audio or other programs at a subscriber's site. While the recording of such programs may take place at any time preceding playback, billing occurs only when, and if, the subscriber chooses to select a program for replay or actually enjoys the program substantially in its entirety. Billing is alternatively based on a store-credit or account debiting scheme. The recording of program materials may be directed automatically by subscriber-operated storage management facilities which scan program schedules and select materials to be recorded, based on title, cast, program genre or any other of a variety of viewer/listener preferences. Alternatively, the program provider may automatically download programs, either based upon actual or surmised viewer preferences, or at the provider's discretion, for example, using newly-available selections.

Abstract: A stored program pay-per-play system includes a high-capacity storage medium facilitating compilation of video, audio or other programs at a subscriber's site. While the recording of such programs may take place at any time preceding playback, billing occurs only when, and if, the subscriber chooses to select a program for replay or actually enjoys the program substantially in its entirety. The program provider may automatically download programs, either based upon actual or surmised viewer preferences, or at the provider's discretion, for example, using newly-available selections. Display generation circuitry is preferably implemented, enabling the viewer to review selections to be downloaded, those selections available for immediate replay, remaining account balance, and other features, including “parental lockout” and so forth.