Abstract: Aspects of the invention include minimally invasive internal target tissue site imaging devices. Devices according to embodiments of the invention include an elongate member dimensioned to access an internal target tissue location, e.g., an intervertebral disc, and having a proximal end and a distal end; a white light source at the distal end; a near-infra-red light source the distal end; and an imaging sensor at the distal end. Also provided are methods of using the systems in imaging applications, as well as kits for performing the methods.

Abstract: Tissue modification devices are provided. Aspects of the devices include an elongated member having a proximal end and a distal end. The distal end of the elongated member is dimensioned to pass through a minimally invasive body opening and includes a distal end integrated visualization sensor and tissue modifier. In some instances, the devices further include an integrated articulation mechanism that imparts steerability to at least one of the visualization sensor, the tissue modifier and the distal end of the elongated member. Also provided are methods of modifying internal target tissue of a subject using the tissue modification devices.

Abstract: Provided herein are biopsy devices each comprised of a tissue collection element having a distal end and a proximal end connected to a drive mechanism. In one embodiment, the tissue collection element can be formed from a material having a first constrained configuration when positioned within the outer needle prior to deployment and a second unconstrained configuration when extended distally beyond the distal end of the outer needle. In another embodiment, the tissue collection element can be formed from a material having a first constrained configuration when a stylet is inserted into the tissue collection element and a second unconstrained configuration when the stylet is retracted from within the tissue collection element. In a third embodiment, the tissue collection element comprises a helical cutting edge along at least a portion of the length of the tissue collection element, wherein the helical cutting edge is adaptable to cut a portion of tissue from the target location.