Patents by Inventor James S. Farina

James S. Farina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Scalable process for the preparation of a rapamycin 42-ester from a rapamycin 42-ester boronate
    Patent number: 7622578
    Abstract: A scalable process for the preparation of a rapamycin 42-ester by reacting a rapamycin 42-ester boronate with a diol and purifying crude rapamycin 42-ester by recrystallization and treatment with a diol is provided. Also provided is a method for isolating and purifying a rapamycin 42-ester boronate from mother liquors comprising acetone and rapamycin contaminants.
    Type: Grant
    Filed: December 6, 2006
    Date of Patent: November 24, 2009
    Assignee: Wyeth
    Inventors: Chunhao Zhang, Clifford William Coughlin, Anthony Pilcher, Adam P. Michaud, James S. Farina, Ayman Sahli
  • Preparation of propranolol hydrochloride macrocrystals
    Patent number: 5095151
    Abstract: There is described a process for the preparation of high yields of propranolol hydrochloride having a particle size within the range of 420 to 1200 microns wherein the propanolol hydrochloride is recrystallized from, as a solvent, a mixture of n-propanol and heptane.The propranolol hydrochloride macrocrystals are useful themselves in capsule pharmaceutical dosage forms and when coated with a sustained release coating composition, are useful in the manufacture of sustained action capsule and tablet pharmaceutical dosage.
    Type: Grant
    Filed: May 21, 1985
    Date of Patent: March 10, 1992
    Assignee: American Home Products Corporation
    Inventors: Paul C. Guley, James S. Farina
  • Preparation of 3-hydroxy-3-phenylbutan-2-one
    Patent number: 4704475
    Abstract: A process is provided for preparing 3-hydroxy-3-phenyl-butan-2-one, useful in the preparation of acifran, in high yields by reacting 2,3-butanedione with the appropriate Grignard reagent at low temperature in tetrahydrofuran or admixtures thereof with toluene.
    Type: Grant
    Filed: June 2, 1986
    Date of Patent: November 3, 1987
    Assignee: American Home Products Corporation (Del.)
    Inventors: James S. Farina, Corbin L. Cummings
  • Process for preparing 1-substituted-6-n-propyl-8-methylimidazo[1,5-d]-as-triazin-4(3H)-ones
    Patent number: 4395547
    Abstract: This disclosure describes a novel process for the preparation of 1-(lower alkyl)substituted derivatives of 6-n-propyl-8-alkylimidazo[1,5-d]-as-triazin-4(3H)-ones which are useful as anti-asthmatic agents.
    Type: Grant
    Filed: February 10, 1982
    Date of Patent: July 26, 1983
    Assignee: American Cyanamid Co.
    Inventors: Sivaraman Raghu, James S. Farina, Steven L. Peake