Abstract: Cyclic peptide compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of coronavirus. Therapeutics are also provided containing a therapeutically effective dose of one or more cyclic peptide compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or pulmonary administration.

Abstract: Synthetic A? peptides, oligomers, their methods of synthesis, and their applications are provided. The A? peptides can form stable, soluble oligomers important for the advancement of knowledge, detection, and treatment of Alzheimer's disease. Antibodies specific to oligomeric A? and their methods of synthesis are also described.

Abstract: Cyclic peptide compounds and methods of their synthesis are provided. Formulations and medicaments are also provided that are directed to the treatment of coronavirus. Therapeutics are also provided containing a therapeutically effective dose of one or more cyclic peptide compounds, present either as pharmaceutically effective salt or in pure form, including, but not limited to, formulations for oral, intravenous, or pulmonary administration.

Abstract: Antimicrobial molecules, their synthesis and use as antimicrobial treatments are described. The antimicrobial compounds are teixobactin analogues. Methods of synthesizing antimicrobial teixobactin analogues are also provided. Antibiotic therapeutics comprising antimicrobial teixobactin analogues are provided, along with methods of and formulations for treating microbial infections using such antimicrobial teixobactin analogues. Prodrugs formed using esterified forms of antimicrobial teixobactin analogues may also be provided.

Abstract: Synthetic A? peptides, oligomers, their methods of synthesis, and their applications are provided. The A? peptides can form stable, soluble oligomers important for the advancement of knowledge, detection, and treatment of Alzheimer's disease. Antibodies specific to oligomeric A? and their methods of synthesis are also described.

Abstract: Synthetic A? peptides, oligomers, their methods of synthesis, and their applications are provided. The A? peptides can form stable, soluble oligomers important for the advancement of knowledge, detection, and treatment of Alzheimer's disease. Antibodies specific to oligomeric A? and their methods of synthesis are also described.

Abstract: Antimicrobial molecules, their synthesis and use as antimicrobial treatments are described. The antimicrobial compounds are teixobactin analogues. Methods of synthesizing antimicrobial teixobactin analogues are also provided. Antibiotic therapeutics comprising antimicrobial teixobactin analogues are provided, along with methods of and formulations for treating microbial infections using such antimicrobial teixobactin analogues. Prodrugs formed using esterified forms of antimicrobial teixobactin analogues may also be provided.

Abstract: Synthetic A? peptides, oligomers, their methods of synthesis, and their applications are provided. The A? peptides can form stable, soluble oligomers important for the advancement of knowledge, detection, and treatment of Alzheimer's disease. Antibodies specific to oligomeric A? and their methods of synthesis are also described.

Abstract: .beta.-Lactones are synthesized from a thiol ester and a ketone by a method which efficiently produces .beta.-lactones in high yields. The method involves combining the thiol ester, a ketone or aldehyde, a base, and an organic solvent at subambient temperatures. The thiol ester and ketone form an adduct, which upon warming, spontaneously cyclizes to yield a .beta.-lactone. .beta.-Lactones formed by this method are then decarboxylated, generally by warming in the presence of an adsorbent in an organic solvent, to stereospecifically form the corresponding alkenes.