Patents by Inventor James S. Sharley

James S. Sharley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemical process of preparing dehydrohedione
    Patent number: 11198667
    Abstract: Disclosed is a chemical process of preparing dehydrohedione from Hedione via ?-chlorination and elimination steps. The process can be conducted in a one-pot process or in a continuous reactor system. Accordingly, a simple and cost effective process of preparing cis-Hedione enriched products is developed through reduction of dehydrohedione in the presence of a chiral catalyst system.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: December 14, 2021
    Assignee: International Flavors & Fragrances Inc.
    Inventors: James S. Sharley, Ian R. Baxendale, Estela Espinos Ferri, Ana Maria Collado Perez, Isabelle Fernandez Fernandez
  • Preparation of cyclic allylic nitro compounds
    Patent number: 10717701
    Abstract: Amine-catalyzed formation of cyclic allylic nitro compounds via nitro-aldol reaction is disclosed. A greener solvent and a cheaper, more robust catalyst than in previous reports are used in the nitro-aldol reaction. After screening a range of catalysts the reaction is developed as a selective method of synthesis of ?-dehydroherbac and the scope is demonstrated with a small collection of additional substrates.
    Type: Grant
    Filed: April 5, 2018
    Date of Patent: July 21, 2020
    Assignee: International Flavors & Fragrences Inc.
    Inventors: Estela Espinos Ferri, Ana Maria Collado Perez, Ian R. Baxendale, James S. Sharley
  • PREPARATION OF CYCLIC ALLYLIC NITRO COMPOUNDS
    Publication number: 20200157038
    Abstract: Amine-catalyzed formation of cyclic allylic nitro compounds via nitro-aldol reaction is disclosed. A greener solvent and a cheaper, more robust catalyst than in previous reports are used in the nitro-aldol reaction. After screening a range of catalysts the reaction is developed as a selective method of synthesis of ?-dehydroherbac and the scope is demonstrated with a small collection of additional substrates.
    Type: Application
    Filed: April 5, 2018
    Publication date: May 21, 2020
    Applicant: International Flavors & Fragrances Inc.
    Inventors: Estela Espinos Ferri, Ana Maria Collado Perez, Ian R. BAXENDALE, James S. SHARLEY
  • CHEMICAL PROCESS OF PREPARING DEHYDROHEDIONE
    Publication number: 20200039915
    Abstract: Disclosed is a chemical process of preparing dehydrohedione from Hedione via ?-chlorination and elimination steps. The process can be conducted in a one-pot process or in a continuous reactor system. Accordingly, a simple and cost effective process of preparing cis-Hedione enriched products is developed through reduction of dehydrohedione in the presence of a chiral catalyst system.
    Type: Application
    Filed: March 30, 2018
    Publication date: February 6, 2020
    Applicant: International Flavors & Fragrances Inc.
    Inventors: James S. SHARLEY, Ian R. BAXENDALE, Estela Espinos Ferri, Ana Maria Collado Perez, Isabelle Fernandez Fernandez
  • Methods of preparing ?,?-unsaturated or ?-halo ketones and aldehydes
    Patent number: 9796653
    Abstract: Copper(II) bromide mediated oxidation of acylated enol and use of the reaction in the synthesis of ?,?-unsaturated or ?-bromo ketones or aldehydes are disclosed. The method provides an efficient and practical process for manufacturing dehydrohedione (DHH) and many other versatile ?,?-unsaturated or ?-bromo ketones or aldehydes in large scales to avoid using precious metal compounds.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: October 24, 2017
    Assignee: INTERNATIONAL FLAVORS & FRAGRANCES INC.
    Inventors: Ian R Baxendale, James S Sharley, Amadeo Fernández Miranda, Ana Maria Collado Pérez
  • METHODS OF PREPARING a,ß-UNSATURATED OR a-HALO KETONES AND ALDEHYDES
    Publication number: 20170174607
    Abstract: Copper(II) bromide mediated oxidation of acylated enol and use of the reaction in the synthesis of ?,?-unsaturated or ?-bromo ketones or aldehydes are disclosed. The method provides an efficient and practical process for manufacturing dehydrohedione (DHH) and many other versatile ?,?-unsaturated or ?-bromo ketones or aldehydes in large scales to avoid using precious metal compounds.
    Type: Application
    Filed: December 19, 2016
    Publication date: June 22, 2017
    Inventors: Ian R. Baxendale, James S. Sharley, Amadeo Fernández Miranda, Ana Maria Collado Pérez