Patents by Inventor James S. Stefely

James S. Stefely has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10919011
    Abstract: Disclosed herein are powder mixing apparatuses and methods that utilize the deagglomerizing and mixing effects of an air flow that impacts a flowing powder. The resulting powder can have smaller particle sizes and/or exhibit a more homogenous mixture than the premixed powder.
    Type: Grant
    Filed: October 19, 2018
    Date of Patent: February 16, 2021
    Assignee: Adamis Pharmaceuticals Corporation
    Inventors: Stephen W. Stein, Michael W. Mueting, Herbert C. Chiou, James S. Stefely
  • Publication number: 20190054435
    Abstract: Disclosed herein are powder mixing apparatuses and methods that utilize the deagglomerizing and mixing effects of an air flow that impacts a flowing powder. The resulting powder can have smaller particle sizes and/or exhibit a more homogenous mixture than the premixed powder.
    Type: Application
    Filed: October 19, 2018
    Publication date: February 21, 2019
    Inventors: Stephen W. Stein, Michael W. Mueting, Herbert C. Chiou, James S. Stefely
  • Patent number: 10188996
    Abstract: Disclosed herein are powder mixing apparatuses and methods that utilize the deagglomerizing and mixing effects of an air flow that impacts a flowing powder. The resulting powder can have smaller particle sizes and/or exhibit a more homogenous mixture than the premixed powder.
    Type: Grant
    Filed: October 2, 2015
    Date of Patent: January 29, 2019
    Assignee: Adamis Pharmaceuticals Corporation
    Inventors: Stephen W. Stein, Michael W. Mueting, Herbert C. Chiou, James S. Stefely
  • Publication number: 20170095782
    Abstract: Disclosed herein are powder mixing apparatuses and methods that utilize the deagglomerizing and mixing effects of an air flow that impacts a flowing powder. The resulting powder can have smaller particle sizes and/or exhibit a more homogenous mixture than the premixed powder.
    Type: Application
    Filed: October 2, 2015
    Publication date: April 6, 2017
    Inventors: Stephen W. Stein, Michael W. Mueting, Herbert C. Chiou, James S. Stefely
  • Patent number: 8062670
    Abstract: Powder compositions exhibiting improved flow properties. The compositions generally contain a bulk solid material in the form of a powder and surface-modified nanoparticles. Methods of improving the flow of powder compositions and devices and articles made using such compositions are also disclosed.
    Type: Grant
    Filed: August 4, 2006
    Date of Patent: November 22, 2011
    Assignee: 3M Innovative Properties Company
    Inventors: Jimmie R. Baran, Jr., Stephen W. Stein, James S. Stefely, Madeline P. Shinbach
  • Patent number: 7718162
    Abstract: The invention comprises a medicinal aerosol composition comprising a propellant, an excipient comprising a functionalized polyethyleneglycol, and a drug. The invention also comprises particulate medicinal compositions comprising particles with a mean mass aerodynamic diameter of less than about 10 microns that incorporate an excipient comprising a functionalized polyethyleneglycol.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: May 18, 2010
    Assignee: 3M Innovative Properties Company
    Inventors: James S. Stefely, Daniel C. Duan
  • Patent number: 7687054
    Abstract: Methods, compounds, and medicinal formulations utilizing biocompatible polymers for delivery of a drug, particularly for solubilizing, stabilizing and/or providing sustained release of drug from topical, implantable, and inhalation systems. Many of the methods, compounds, and medicinal formulations are particularly suitable for oral and/or nasal inhalation and use polymers of the formula —[X—R1—C(O)]— wherein each R1 is an independently selected organic group that links the —X— group to the carbonyl group, and each X is independently oxygen, sulfur, or catenary nitrogen.
    Type: Grant
    Filed: February 18, 2002
    Date of Patent: March 30, 2010
    Assignee: 3M Innovative Properties Company
    Inventors: James S. Stefely, David W. Schultz, Chester L. Leach, Daniel C. Duan
  • Patent number: 7597897
    Abstract: Methods for the manufacture of medicinal compositions are described. A method for the manufacture of a medicinal composition according to the invention comprises: (a) Providing a biocompatible polymer of the general formula —[O—R1—C(O)]n— wherein: “R1” is a linear, branched, or cyclic organic group, “n” is at least three, (b) Acylating the biocompatible polymer to provide an acylated biocompatible polymer and a mixed anhydride; (c) Reacting the mixed anhydride with a nucleophile to provide an acylated biocompatible polymer with a terminal carboxylic acid derivative capable of being chemically converted to an acid in the absence of water, (d) Converting the terminal carboxylic acid derivative to an acylated biocompatible polymer with a terminal carboxylic acid; and (e) Combining the acylated biocompatible polymer with a drug to provide the medicinal composition.
    Type: Grant
    Filed: December 10, 2004
    Date of Patent: October 6, 2009
    Assignee: 3M Innovative Properties Company
    Inventors: John T. Capecchi, James S. Stefely, Peter M. Seiler
  • Publication number: 20090123391
    Abstract: A pharmaceutical aerosol formulation includes a therapeutically effective amount of particulate medicament of formula (I) or a solvate thereof, a propellant selected from the group consisting of 1,1,1,2-tetrafluoroethane, 1,1,1,2,3,3,3-heptafluoro-n-propane or mixtures thereof, and a biocompatible polymer comprising one or more compounds of formula (II)
    Type: Application
    Filed: March 21, 2007
    Publication date: May 14, 2009
    Applicant: 3M INNOVATIVE PROPERTIES COMPANY
    Inventors: John T. Capecchi, James S. Stefely
  • Patent number: 7476694
    Abstract: In one aspect, the invention provides a stable dispersion comprising a continuous phase comprising a continuous liquid phase and a plurality of organic nanoparticles; and a dispersed phase comprising particles dispersed in the continuous phase.
    Type: Grant
    Filed: August 10, 2006
    Date of Patent: January 13, 2009
    Assignee: 3M Innovative Properties Company
    Inventors: Jimmie R. Baran, Jr., Brian J. Gabrio, James S. Stefely, Stephen W. Stein
  • Patent number: 7459146
    Abstract: The invention relates to stabilized dispersions containing nanoparticles of use for the administration of medicaments. The dispersions comprise excipient nanoparticles, a dispersed phase comprising medicament and a continuous phase comprising propellant.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: December 2, 2008
    Assignee: 3M Innovative Properties Company
    Inventors: Jimmie R. Baran, Jr., Brian J. Gabrio, James S. Stefely, Stephen W. Stein, Thomas E. Wood
  • Publication number: 20080286362
    Abstract: Powder compositions exhibiting improved flow properties. The compositions generally contain a bulk solid material in the form of a powder and surface-modified nanoparticles. Methods of improving the flow of powder compositions and devices and articles made using such compositions are also disclosed.
    Type: Application
    Filed: August 4, 2006
    Publication date: November 20, 2008
    Inventors: Jimmie R. Baran Jr., Stephen W. Stein, James S. Stefely, Madeline P. Shinbach
  • Publication number: 20080268062
    Abstract: This invention relates to particle-in-liquid dispersions containing surface-modified inorganic nanoparticles.
    Type: Application
    Filed: July 3, 2008
    Publication date: October 30, 2008
    Inventors: Jimmie R. Baran, Brian J. Gabrio, James S. Stefely, Stephen W. Stein, Thomas E. Wood
  • Publication number: 20080267885
    Abstract: Methods for the manufacture of medicinal compositions are described. A method for the manufacture of a medicinal composition according to the invention comprises: (a) Providing a biocompatible polymer of the general formula —[O—R1—C(O)]n— wherein: “R1” is a linear, branched, or cyclic organic group, “n” is at least three, (b) Acylating the biocompatible polymer to provide an acylated biocompatible polymer and a mixed anhydride; (c) Reacting the mixed anhydride with a nucleophile to provide an acylated biocompatible polymer with a terminal carboxylic acid derivative capable of being chemically converted to an acid in the absence of water, (d) Converting the terminal carboxylic acid derivative to an acylated biocompatible polymer with a terminal carboxylic acid; and (e) Combining the acylated biocompatible polymer with a drug to provide the medicinal composition.
    Type: Application
    Filed: December 10, 2004
    Publication date: October 30, 2008
    Inventors: John T. Capecchi, James S. Stefely, Peter M. Seiler
  • Patent number: 7425582
    Abstract: In one aspect, the invention provides a stable dispersion comprising a continuous phase comprising a continuous liquid phase and a plurality of organic nanoparticles; and a dispersed phase comprising particles dispersed in the continuous phase.
    Type: Grant
    Filed: August 10, 2006
    Date of Patent: September 16, 2008
    Assignee: 3M Innovative Properties Company
    Inventors: Jimmie R. Baran, Jr., Brian J. Gabrio, James S. Stefely, Stephen W. Stein
  • Publication number: 20080112894
    Abstract: Stability of biocompatible polymers of the formula: wherein Z is —C(O)R1; each R1 is independently selected from a linear, branched, or cyclic alkyl, alkoxy, or aryl with 1 to 18 carbon atoms optionally substituted by carbonyl, oxy, thio, and/or nitrogen; each R2 is independently selected from hydrogen or a linear or branched hydrocarbon with 1 to 4 carbon atoms; X is selected from the group consisting of —OR1, —SR1, —N(R1)2 and divalent or trivalent headgroups terminated in oxygen, nitrogen, or sulfur; y is greater than or equal to 1 and less than or equal to 3; is enhanced by providing compositions where there is a low level of —OH end group impurity, i.e., where Z is —H instead of —C(O)R1 and/or X is —OH instead of —OR1, —SR1, —N(R1)2 or divalent or trivalent headgroups terminated in —O—, —N—, or —S—, such that there are no more than 10 of these —OH end groups for every 100 intended biocompatible polymer molecules.
    Type: Application
    Filed: March 14, 2006
    Publication date: May 15, 2008
    Inventors: John T. Capecchi, James S. Stefely
  • Patent number: 7186402
    Abstract: The invention comprises a medicinal aerosol composition comprising a propellant, an excipient comprising an acid or amine end-group and at least one and no more than two amide and/or ester functional groups, and a drug. The invention also comprises particulate medicinal compositions comprising particles with a mean mass aerodynamic diameter of less than about 10 microns that incorporate an excipient containing an acid or amine end-group and at least one and no more than two amide and/or ester functional groups.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: March 6, 2007
    Assignee: 3M Innovative Properties Company
    Inventors: Daniel C. Duan, Robert A. Scherrer, James S. Stefely
  • Patent number: 7141612
    Abstract: The invention relates to stabilized gas-in-liquid dispersions or foams containing a liquid continuous phase, a dispersed gas phase, and surface-modified fullerenes, dendrimers, organic polymeric microspheres, or combinations thereof.
    Type: Grant
    Filed: December 31, 2002
    Date of Patent: November 28, 2006
    Assignee: 3M Innovative Properties Company
    Inventors: Jimmie R. Baran, Jr., James S. Stefely, Stephen W. Stein
  • Patent number: 7109247
    Abstract: In one aspect, the invention provides a stable dispersion comprising a continuous phase comprising a continuous liquid phase and a plurality of organic nanoparticles; and a dispersed phase comprising particles dispersed in the continuous phase.
    Type: Grant
    Filed: May 30, 2003
    Date of Patent: September 19, 2006
    Assignee: 3M Innovative Properties Company
    Inventors: Jimmie R. Baran, Jr., James S. Stefely
  • Patent number: 7001580
    Abstract: The invention is related to emulsions containing surface-modified organic molecules, organic polymeric microspheres, or combinations thereof.
    Type: Grant
    Filed: December 31, 2002
    Date of Patent: February 21, 2006
    Assignee: 3M Innovative Properties Company
    Inventors: Jimmie R. Baran, Jr., James S. Stefely, Stephen W. Stein