Abstract: Disclosed herein are topical formulations for treating depression with S adenosyl methionine (SAM-e) The topical formulations contain at least 35% wt/wt of SAM-e partially dissolved in aqueous and lipophilic phases of an emulsion and the emulsion is stable from separation of phases for a period of at least 30 days despite the high concentration of SAM-e. Also provided are methods for making such compositions and methods of treating depression using the same.

Abstract: A hose reel that includes a spool that is formed by attaching a pair of spool flange plates to opposite sides of hub assembly. The hub assembly is an integral unitary structure that includes central hub, a plurality of spokes extending radially from the central hub, a plurality of hub sections provided at the radial ends of the plurality of spokes which define a cylindrical surface upon which a hose can be wound, an annular bracing element connected between the plurality of spokes, and a latch gear provided on the annular bracing element. The central hub includes a spring catch that is configured to engage a spring of a rewinding mechanism.