Patents by Inventor James Shayman

James Shayman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
    Publication number: 20070203223
    Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
    Type: Application
    Filed: February 5, 2007
    Publication date: August 30, 2007
    Inventors: Craig Siegel, James Shayman, Carol Nelson, David Harris, Diane Copeland
  • Amino ceramide-like compounds and therapeutic methods of use
    Publication number: 20070072916
    Abstract: Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: September 15, 2006
    Publication date: March 29, 2007
    Applicant: The Regents of the University of Michigan
    Inventor: James Shayman
  • Amino ceramide-like compounds and therapeutic methods of use
    Publication number: 20060217560
    Abstract: Novel prodrugs of amino ceramide-like compounds are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: March 8, 2006
    Publication date: September 28, 2006
    Inventor: James Shayman
  • Methods and compositions for using aleveolar macrophage phospholipase A2
    Publication number: 20060008455
    Abstract: The present invention is directed to methods and compositions for improving pulmonary surfactant catabolism. More specifically, the specification describes methods and compositions for making and using a lysosomal phospholipase A2 in methods for the diagnosis, and treatment of disorders of phospholipid catabolism such as pulmonary alveolar proteinosis.
    Type: Application
    Filed: March 15, 2005
    Publication date: January 12, 2006
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: James Shayman, Akira Abe, Miki Hiraoka
  • Methods and compositions for using aleveolar macrophage phospholipase A2
    Publication number: 20050281803
    Abstract: The present invention is directed to methods and compositions for improving pulmonary surfactant catabolism. More specifically, the specification describes methods and compositions for making and using a lysosomal phospholipase A2 in methods for the diagnosis, and treatment of disorders of phospholipid catabolism such as pulmonary alveolar proteinosis.
    Type: Application
    Filed: April 28, 2005
    Publication date: December 22, 2005
    Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: James Shayman, Akira Abe, Miki Hiraoka
  • Amino ceramide-like compounds and therapeutic methods of use
    Publication number: 20050267094
    Abstract: The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: April 29, 2005
    Publication date: December 1, 2005
    Inventors: James Shayman, David Harris, Craig Siegel, Carol Nelson, Diane Copeland
  • Amino ceramide-like compounds and therapeutic methods of use
    Publication number: 20050239862
    Abstract: Novel amino ceramide-like compounds (1) are provided which inhibit glucosyl ceramide (GlcCer) formation by inhibiting the enzyme GlcCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore highly useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: March 10, 2005
    Publication date: October 27, 2005
    Applicant: The Regents of the University of Michigan
    Inventors: James Shayman, Norman Radin
  • Synthesis of UDP-glucose: N-acylsphingosine glucosyltransferase inhibitors
    Publication number: 20050222244
    Abstract: Disclosed is a novel enantiomeric synthesis ceramide-like inhibitors of UDP-glucose: N-acylsphingosine glucosyltransferase. Also disclosed are novel intermediates formed during the synthesis.
    Type: Application
    Filed: March 28, 2005
    Publication date: October 6, 2005
    Applicants: Genzyme Corporation, The Regents of the University of Michigan
    Inventors: Craig Siegel, James Shayman, Carol Nelson, David Harris, Diane Copeland
  • Amino ceramide-like compounds and therapeutic methods of use
    Publication number: 20050049235
    Abstract: The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
    Type: Application
    Filed: May 5, 2004
    Publication date: March 3, 2005
    Applicant: The Regents of the University of Michigan
    Inventors: James Shayman, Norman Radin