Abstract: There is provided a fan assembly comprising a motor-driven impeller arranged to generate an airflow, an air outlet arranged to emit the airflow, a plurality of sensors arranged to measure a value for each of a plurality of air quality characteristics, a display and a processor. The processor is configured to receive measured values for each of the plurality of air quality characteristics, identify one of a corresponding set of intervals within which the measured value falls and select an air quality index value associated with the identified interval. The processor is then configured to identify the highest of the selected air quality index values as a current overall air quality index value and to cause the display to display a time series plot of the current air quality index value and a number of preceding air quality index values.

Abstract: Disclosed herein are methods to treat a neurodegenerative disease comprising administering to a subject with a neurodegenerative disease a therapeutically effective amount of a polynucleotide that binds a nucleic acid-binding polypeptide, wherein the nucleic acid-binding polypeptide can aggregate in cells and is associated with a neurodegenerative disease. Also disclosed are methods to inhibit protein aggregation in a cell comprising contacting the cell with a composition comprising a polynucleotide that binds a nucleic acid-binding polypeptide, wherein the nucleic acid-binding polypeptide can aggregate in cells and is associated with a neurodegenerative disease. Additionally disclosed are compositions comprising a polynucleotide that binds a nucleic acid-binding polypeptide, wherein the nucleic acid-binding polypeptide can aggregate in cells and is associated with a neurodegenerative disease.

Abstract: Protein misfolding underpins several fatal neurodegenerative disorders. The application is directed to recombinant Hsp104 proteins comprising missense mutations aimed at correcting these events, and methods for expressing and delivering same.

Abstract: Protein misfolding underpins several fatal neurodegenerative disorders. The application is directed to recombinant Hsp104 proteins comprising missense mutations aimed at correcting these events, and methods for expressing and delivering same.

Abstract: The invention relates to compounds which inhibit aggregation of proteins or peptides, or disaggregate protein aggregates, and thereby antagonize the toxic effects of such aggregates. The invention also relates to methods for using such compounds and methods for discovering compounds that inhibit protein or peptide aggregation.

Abstract: The present invention provides novel polypeptides comprising a prion-aggregation domain and a second domain; novel polynucleotides encoding such polypeptides; host cells transformed or transfected with such polynucleotides; novel fibrils with specific functionalities and unusually high chemical and thermal stability; and methods of making and using the foregoing.

Abstract: A Cutting Machine for processing leafy vegetables such as collard greens is provided. The Cutting Machine is adjustable to accommodate vegetables of varying thicknesses. An enclosure with a cover has an input opening in the cover to feed material to be cut between the rollers. An actuating shaft which is rotated includes an offset wheel and an offset shaft. An actuating rod on the offset wheel swings a pivoting knife back and forth to cut the material. An actuating shaft which is connected to the offset shaft moves a roller cog mounted on the drive roller.

Abstract: A Cutting Machine for processing leafy vegetables such as collard greens is provided. The Cutting Machine is adjustable to accommodate vegetables of varying thicknesses. An enclosure with a cover has an input opening in the cover to feed material to be cut between the rollers. An actuating shaft which is rotated includes an offset wheel and an offset shaft. An actuating rod on the offset wheel swings a pivoting knife back and forth to cut the material. An actuating shaft which is connected to the offset shaft moves a roller cog mounted on the drive roller.

Abstract: A food cutting device for processing leafy vegetables such as collard greens having a groove roller and a cutting roller with discs which engage the grooves of the groove roller to cut the leafy vegetable longitudinally and a cam-actuated blade that cuts the leafy vegetable across the longitudinal cuts.