Patents by Inventor James Shurtleff

James Shurtleff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240165250
    Abstract: The present disclosure provides a class of compounds including a ligand moiety that specifically binds to a cell surface receptor, such as a folate receptor. The cell surface folate binding compound can trigger the receptor to internalize into the cell a bound compound. The ligand moieties of this disclosure can be linked to a variety of moieties of interest without impacting the specific binding to, and function of, the cell surface receptor, e.g., folate receptor. Also provided are compounds that are conjugates of the ligand moieties linked to a biomolecule, such as an antibody, which conjugates can harness cellular pathways to remove specific proteins of interest from the cell surface or from the extracellular milieu. Also provided herein are methods of using the conjugates to target a polypeptide of interest for sequestration and/or lysosomal degradation.
    Type: Application
    Filed: January 10, 2022
    Publication date: May 23, 2024
    Inventors: Jason G. Lewis, Eric D. Turtle, Brett Bradley Busch, Justin Thomas Ernst, Garrick K. Packard, Matthew James Shurtleff
  • Publication number: 20070189940
    Abstract: The apparatus includes a liquid permeable pouch that defines a cavity for maintaining an anhydrous hydride reactant, wherein the cavity comprises a cross-section such that a point within the cross-section is separated from a perimeter of the liquid permeable pouch by no more than double the permeation distance, and a cartridge configured to receive the liquid permeable pouch and a liquid reactant such that at least a portion of the liquid permeable pouch is submerged in the liquid reactant. The system includes a plurality of pouches formed from two rectangular sheets of liquid permeable material, and each pouch has a width selected such that each point within a cross-section is separated from the sheets by no more than double the permeation distance. The method includes joining the sheets, forming one or more seals to define a cavity, disposing anhydrous hydride within the cavity, and sealing the opening.
    Type: Application
    Filed: April 26, 2007
    Publication date: August 16, 2007
    Inventors: James Shurtleff, John Patton, Eric Ladd
  • Publication number: 20070056726
    Abstract: An apparatus, system, and method are disclosed for in-situ extraction of oil from oil shale. The method comprises drilling a fluid conduit in fluid communication with a top and a bottom of a target zone within an oil shale formation. The method includes stimulating the target zone. The method further includes injecting a heated fluid into the bottom of the target zone such that the heated fluid entrains the kerogen within the target zone into the injected fluid to generate a production fluid. The method concludes with producing the production fluid, containing the in-situ kerogen, from the top of the target zone to the surface.
    Type: Application
    Filed: September 13, 2006
    Publication date: March 15, 2007
    Inventor: James Shurtleff
  • Publication number: 20060059778
    Abstract: A fuel cartridge for a hydrogen generating system having a cartridge containing a substantially anhydrous chemical hydride reactant. A plurality of liquid conduits extends into the cartridge and each of the liquid conduits has a length and a plurality of liquid distribution apertures formed along the length. The liquid distribution apertures have a diameter of less than approximately 1 mm. The chemical hydride reactant forms a bed and the liquid conduits extend along at least half of a length of the bed.
    Type: Application
    Filed: November 12, 2005
    Publication date: March 23, 2006
    Inventors: James Shurtleff, Eric Ladd, Chris Brydon, John Patton, J. Anderson