Patents by Inventor James Sikela

James Sikela has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR IDENTIFYING AGENTS THAT MODULATE p44
    Publication number: 20100159440
    Abstract: The present invention provides methods for identifying evolutionarily significant polynucleotide and polypeptide sequences in human and/or non-human primates which may be associated with a physiological condition, such as enhanced resistance to HCV infection. The invention also provides methods for identifying evolutionarily significant polynucleotides with mutations that are correlated with susceptibility to diseases, such as BRCA1 exon 11. The methods employ comparison of human and non-human primate sequences using statistical methods. Sequences thus identified may be useful as host therapeutic targets and/or in screening assays.
    Type: Application
    Filed: December 9, 2008
    Publication date: June 24, 2010
    Applicant: Evolutionary Genomics, Inc.
    Inventors: Walter Messier, James Sikela
  • Methods for identifying agents that increase the p44 function of microtubule assembly or resistance to HCV infection
    Patent number: 7462460
    Abstract: The present invention provides methods for identifying evolutionarily significant polynucleotide and polypeptide sequences in human and/or non-human primates which may be associated with a physiological condition, such as enhanced resistance to HCV infection. The invention also provides methods for identifying evolutionarily significant polynucleotides with mutations that are correlated with susceptibility to diseases, such as BRCA1 exon 11. The methods employ comparison of human and non-human primate sequences using statistical methods. Sequences thus identified may be useful as host therapeutic targets and/or in screening assays.
    Type: Grant
    Filed: February 15, 2005
    Date of Patent: December 9, 2008
    Assignee: Evolutionary Genomics, Inc.
    Inventors: Walter Messier, James Sikela
  • Methods to identify polynucleotide and polypeptide sequences which may be associated with physiological and medical conditions
    Publication number: 20050164174
    Abstract: The present invention provides methods for identifying evolutionarily significant polynucleotide and polypeptide sequences in human and/or non-human primates which may be associated with a physiological condition, such as enhanced resistance to HCV infection. The invention also provides methods for identifying evolutionarily significant polynucleotides with mutations that are correlated with susceptibility to diseases, such as BRCA1 exon 11. The methods employ comparison of human and non-human primate sequences using statistical methods. Sequences thus identified may be useful as host therapeutic targets and/or in screening assays.
    Type: Application
    Filed: February 15, 2005
    Publication date: July 28, 2005
    Inventors: Walter Messier, James Sikela
  • Methods to identify polynucleotide and polypeptide sequences which may be associated with physiological and medical conditions
    Patent number: 6866996
    Abstract: The present invention provides methods for identifying evolutionarily significant polynucleotide and polypeptide sequences in human and/or non-human primates which may be associated with a physiological condition, such as enhanced resistance to HCV infection. The invention also provides methods for identifying evolutionarily significant polynucleotides with mutations that are correlated with susceptibility to diseases, such as BRCA1 exon 11. The methods employ comparison of human and non-human primate sequences using statistical methods. Sequences thus identified may be useful as host therapeutic targets and/or in screening assays.
    Type: Grant
    Filed: March 14, 2002
    Date of Patent: March 15, 2005
    Assignee: Evolutionary Genomics, LLC
    Inventors: Walter Messier, James Sikela