Abstract: The present invention relates to multiphasic, three-dimensionally printed, tissue repair devices or scaffolds useful for promoting bone growth and treating bone fracture, defect or deficiency, methods for making the same and methods for promoting bone growth and treating bone fracture, defect or deficiency using the same. The scaffold has a porous bone ingrowth area containing interconnected struts surrounded by a microporous shell. At the ends of the scaffold, the shell may be extended as a guide flange to stabilize the scaffold between ends of bone. The center of the scaffold may be empty and may serve as a potential marrow space. The porous ingrowth structure may be infiltrated with a soluble filler or carrier, such as, for example calcium sulfate which may be infiltrated with one or more of an antibiotic, a growth factor, a differentiation factors, a cytokine, a drug, or a combination of these agents.

Abstract: Firstly, a custom designed 3D printer with x-y-z gantry robot with an accuracy of 0.1 ?m was adapted with a custom designed printing head (51b). Secondly, a two component silicone elastomer suitable for RP was developed that incorporates the desired characteristics and properties similar to those commercially available for the provision of facial and body prostheses. The silicone elastomer is composed of polydimethylsiloxane (PDMS) chains, filler, catalyst and crosslinker. By varying the amount of these components the mechanical properties of the silicone elastomer can be altered, for example, tensile strength, tear strength, hardness and wettability. To achieve these desired properties consideration must also be given to the set time and viscosity of the silicone elastomer and additionally the speed at which the material is printed.

Abstract: The present invention relates to multiphasic, three-dimensionally printed, tissue repair devices or scaffolds useful for promoting bone growth and treating bone fracture, defect or deficiency, methods for making the same and methods for promoting bone growth and treating bone fracture, defect or deficiency using the same. The scaffold has a porous bone ingrowth area containing interconnected struts surrounded by a microporous shell. At the ends of the scaffold, the shell may be extended as a guide flange to stabilize the scaffold between ends of bone. The center of the scaffold may be empty and may serve as a potential marrow space. The porous ingrowth structure may be infiltrated with a soluble filler or carrier, such as, for example calcium sulfate which may be infiltrated with one or more of an antibiotic, a growth factor, a differentiation factors, a cytokine, a drug, or a combination of these agents.