Abstract: Provided herein are compounds of Formula (I), their pharmaceutically acceptable salts, and their pharmaceutical compositions: wherein R1, R2, R3a, R3b, R4, R5, and A are defined in the present disclosure. The compounds are potent inhibitors of the main protease (Mpro) of severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2), and they are useful in treating or preventing COVID-19 in a subject.

Abstract: A system for processing and presenting a conversation includes a sensor, a processor, and a presenter. The sensor is configured to capture an audio-form conversation. The processor is configured to automatically transform the audio-form conversation into a transformed conversation. The transformed conversation includes a synchronized text, wherein the synchronized text is synchronized with the audio-form conversation. The presenter is configured to present the transformed conversation including the synchronized text and the audio-form conversation. The presenter is further configured to present the transformed conversation to be navigable, searchable, assignable, editable, and shareable.

Abstract: Computer-implemented method and system for receiving and processing one or more moment-associating elements. For example, the computer-implemented method includes receiving the one or more moment-associating elements, transforming the one or more moment-associating elements into one or more pieces of moment-associating information, and transmitting at least one piece of the one or more pieces of moment-associating information.

Abstract: Disclosed are methods for thermally treating a particle material which used in a chromatographic separation device. The particle material is thermally treated for purposes of controlling and reducing its porosity. Also disclosed are chromatographic separation devices utilizing the thermally treated particle material of the present invention.

Abstract: Disclosed are methods of making a porous particle material for use as stationary media and related chromatographic separation devices utilizing the disclosed stationary media.

Abstract: Disclosed herein is a method for immunotherapy of a patient with urothelial carcinoma (UC) comprising administering to the patient an anti-PD-1 antibody reduces Fc?R binding thus reducing antibody-dependent phagocytosis.

Abstract: A bonding apparatus for bonding electronic devices including substrates comprises first and second rails arranged adjacent to each other which are configured to align the substrates in vertical orientations during transportation along the rails. A bonding system is locatable over a first bonding site which is located along the first rail and a second bonding site which is located along the second rail. A first indexer is located adjacent to the first rail and a second indexer is located adjacent to the second rail wherein each indexer is independently operative to transport a substrate along one rail while a substrate held on the other rail is being bonded. A container located at one end of the rails for holding multiple unbonded substrates is operative to feed unbonded substrates directly to the rails.

Abstract: Wire is fed to a bonding tool of a wire bonder by a pneumatic device that is operative to urge the wire to feed through an outlet of the pneumatic device towards the bonding tool. A wire clamp is located adjacent to the outlet of the pneumatic device and a wire guider with a hole is located adjacent to the wire clamp between the wire clamp and the bonding tool for threading the wire through the hole before being fed to the bonding tool.

Abstract: A main body of an apparatus for delivering shielding gas during wire bonding of an electronic device has a through-hole in the main body which is sized for allowing a capillary tip of a bonding tool to be insertable through the main body when performing wire bonding. At least one gas outlet located on a bottom surface of the main body adjacent to the through-hole is operative to direct an inert gas in a direction towards the electronic device. At least one gas inlet in the main body is operative to supply the inert gas to the through-hole and to the gas outlet.

Abstract: A wire bonder comprises a bonding tool for forming wire bonds and a pneumatic device for feeding wire to the bonding tool. An upper clamp and a lower clamp are aligned along a wire feeding route between the pneumatic device and the bonding tool to clamp the wire at respective clamping points. A fixed intermediate guiding chamber extends substantially from the upper clamp to the lower clamp. The said intermediate guiding chamber encloses the wire along the wire feeding route and is operative to shield and guide the wire.

Abstract: A main body of an apparatus for delivering shielding gas during wire bonding of an electronic device has a through-hole in the main body which is sized for allowing a capillary tip of a bonding tool to be insertable through the main body when performing wire bonding. At least one gas outlet located on a bottom surface of the main body adjacent to the through-hole is operative to direct an inert gas in a direction towards the electronic device. At least one gas inlet in the main body is operative to supply the inert gas to the through-hole and to the gas outlet.

Abstract: Wire is fed to a bonding tool of a wire bonder by a pneumatic device that is operative to urge the wire to feed through an outlet of the pneumatic device towards the bonding tool. A wire clamp is located adjacent to the outlet of the pneumatic device and a wire guider with a hole is located adjacent to the wire clamp between the wire clamp and the bonding tool for threading the wire through the hole before being fed to the bonding tool.

Abstract: A bonding apparatus for bonding electronic devices including substrates comprises first and second rails arranged adjacent to each other which are configured to align the substrates in vertical orientations during transportation along the rails. A bonding system is locatable over a first bonding site which is located along the first rail and a second bonding site which is located along the second rail. A first indexer is located adjacent to the first rail and a second indexer is located adjacent to the second rail wherein each indexer is independently operative to transport a substrate along one rail while a substrate held on the other rail is being bonded. A container located at one end of the rails for holding multiple unbonded substrates is operative to feed unbonded substrates directly to the rails.

Abstract: A portable conversion washing device includes a pole, a brush support having a soap container, a brush, and a soap dispensing device that has a soap plug that plugs a dispensing opening, an actuator that moves the soap plug away from the dispensing opening whereby soap is dispensed out of the soap container, and a return device that moves the soap plug back to the dispensing opening. The washing device also includes a running water supply device having a first pipe connected to a running water supply hose, a second pipe that is in fluid communication with the first pipe, an angle adjusting device that adjust the angle between the first pipe and the second pipe. The second pipe has a tapered water conduit, a water flow plug that is moved along the conduit, and a water flow shaft that moves the water flow plug within the conduit.

Abstract: A large electronic device having a bonding area on one side that comprises first and second portions may be bonded by first locating the first portion but not the second portion of the electronic device for bonding by a bonding tool. After the first portion of the electronic device has been bonded, the electronic device is conveyed to a rotary platform that is rotatable along a substantially horizontal plane. The electronic device is rotated on the rotary platform to change the respective positions of the bonded first portion and unbonded second portion of the electronic device, before the electronic device is conveyed to the bonding tool such that the second portion of the electronic device is located for bonding by the bonding tool. The second portion of the electronic device may then be bonded.

Abstract: A bonding apparatus is provided which includes a device handler for handling electronic devices, the bonding apparatus including a bonding tool at which the electronic devices are locatable for bonding. A storage assembly is provided for storing multiple electronic devices and a conveying track is further provided for conveying electronic devices towards and away from the bonding tool. The device handler includes a rotary platform for holding an electronic device, and which is operable between an orientation wherein the rotary platform is aligned with the conveying track for transferring an electronic device between the rotary platform and the conveying track, and another orientation wherein the rotary platform is aligned with the storage assembly for transferring an electronic device between the rotary platform and the storage assembly.

Abstract: A portable conversion washing device includes a pole, a brush support having a soap container, a brush, and a soap dispensing device that has a soap plug that plugs a dispensing opening, an actuator that moves the soap plug away from the dispensing opening whereby soap is dispensed out of the soap container, and a return device that moves the soap plug back to the dispensing opening. The washing device also includes a running water supply device having a first pipe connected to a running water supply hose, a second pipe that is in fluid communication with the first pipe, an angle adjusting device that adjust the angle between the first pipe and the second pipe. The second pipe has a tapered water conduit, a water flow plug that is moved along the conduit, and a water flow shaft that moves the water flow plug within the conduit.

Abstract: An article 100 and realted methods for reducing a microbial population on an article 168, wherein apparatus 100 includes a chamber in an article-holding basket 164 retains article 168 in an up-right position within the cahbmer an enclosing article 168. A heating system 172 introduces dry heat, moist heat, and, if desired, a combination of moist heat and dry heat into the chamber. A fluid supply system delivers a predetermine amount of fluid to a heating reservoir 174, which is disposed above heating system 172 to provide the moist heat.

Abstract: A bonding apparatus is provided which includes a device handler for handling electronic devices, the bonding apparatus including a bonding tool at which the electronic devices are locatable for bonding. A storage assembly is provided for storing multiple electronic devices and a conveying track is further provided for conveying electronic devices towards and away from the bonding tool. The device handler includes a rotary platform for holding an electronic device, and which is operable between an orientation wherein the rotary platform is aligned with the conveying track for transferring an electronic device between the rotary platform and the conveying track, and another orientation wherein the rotary platform is aligned with the storage assembly for transferring an electronic device between the rotary platform and the storage assembly.