Patents by Inventor James Stanley Kaltenbronn

James Stanley Kaltenbronn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes
    Patent number: 6982260
    Abstract: This invention provides quinazolines that are useful for treating cell proliferative diseases and disorders, such as cardiovascular diseases, infections, cancers, autoimmune diseases, gout, kidney disease, and neurodegenerative diseases and disorders such as Alzheimer's disease. We have now discovered a group of 2-arylamino-7-(alkyl)oxy-8-alkylquinazolines and 8-alkyl-2-arylamino-quinazoline 2,7-diamines that are potent inhibitors of cyclin-dependent kinases (cdks). The compounds are readily synthesized and can be administered by a variety of routes, including orally, and have sufficient bioavailability. This invention also provides pharmaceutical formulations comprising at least one of the quinazoline compounds together with a pharmaceutically acceptable carrier, diluent, or excipient therefor. The invention further provide useful intermediates generated during the production of the quinazoline compounds.
    Type: Grant
    Filed: November 3, 2000
    Date of Patent: January 3, 2006
    Assignee: Warner-Lambert Company
    Inventors: Mark Robert Barvian, Ellen Myra Dobrusin, James Stanley Kaltenbronn, Peter L. Toogood, Roy Thomas Winters, Inderjit S. Sidhu, Rajeshwar Singh, Yadagiri Bathini, Ronald George Micetich
  • 5-substituted tetralones as inhibitors of ras farnesyl transferase
    Patent number: 6943183
    Abstract: The present invention provides novel 5-substituted tetralones of Formulas I, II, III, and IV and pharmaceutically acceptable salts, esters, amides, and prodrugs thereof, which are useful for treating and preventing uncontrolled or abnormal proliferation of tissues, such as cancer, atherosclerosis, restenosis, and psoriasis.
    Type: Grant
    Filed: April 16, 2001
    Date of Patent: September 13, 2005
    Assignee: Pfizer Inc
    Inventors: William Alexander Denny, Richard H. Hutchings, Douglas S. Johnson, James Stanley Kaltenbronn, Ho Huat Lee, Daniele Marie Leonard, Jared Bruce John Milbank, Joseph Thomas Repine, Gordon William Rewcastle, Andrew David White
  • Bicyclic inhibitors of protein farnesyl transferase
    Patent number: 6528535
    Abstract: The present invention provide compounds of Formula I The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula I.
    Type: Grant
    Filed: July 23, 2001
    Date of Patent: March 4, 2003
    Assignee: Warner-Lambert Company
    Inventors: Jack Bikker, Ellen Myra Dobrusin, Annette Marian Doherty, Matthew Drowns, James Stanley Kaltenbronn, Juergen Kleinschroth, Dennis Joseph McNamara, John Quin, III, Joseph Thomas Repine, Marcin Stasiak
  • Functionalized alkyl and alenyl side chain derivatives of glycinamides as farnesyl transferase inhibitors
    Patent number: 6369034
    Abstract: The present invention provides compounds of Formula (I). The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula (I).
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: April 9, 2002
    Assignee: Warner-Lambert Company
    Inventors: Annette Marian Doherty, James Stanley Kaltenbronn, Daniele Marie Leonard, Dennis Joseph McNamara, John Quin, III
  • Bicyclic inhibitors of protein farnesyl transferase
    Publication number: 20020006936
    Abstract: The present invention provides compounds of Formula I 1
    Type: Application
    Filed: July 23, 2001
    Publication date: January 17, 2002
    Inventors: Jack Bikker, Ellen Myra Dobrusin, Annette Marian Doherty, Matthew Drowns, James Stanley Kaltenbronn, Juergen Kleinschroth, Dennis Joseph McNamara, John Quin, Joseph Thomas Repine, Marcin Stasiak
  • Bicyclic inhibitors of protein farnesyl transferase
    Patent number: 6265422
    Abstract: The present invention provides compounds of Formula I The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula I.
    Type: Grant
    Filed: April 28, 2000
    Date of Patent: July 24, 2001
    Assignee: Warner-Lambert Company
    Inventors: Jack Bikker, Ellen Myra Dobrusin, Annette Marian Doherty, Matthew Drowns, James Stanley Kaltenbronn, Juergen Kleinschroth, Dennis Joseph McNamara, John Quin, III, Joseph Thomas Repine, Marcin Stasiak
  • Benzopyranone and quinolone inhibitors of ras farnesyl transferase
    Patent number: 6143766
    Abstract: The present invention provides ras farnesyl transferase inhibiting compounds of Formula I ##STR1## The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula I.
    Type: Grant
    Filed: January 20, 2000
    Date of Patent: November 7, 2000
    Assignee: Warner-Lambert Company
    Inventors: James Stanley Kaltenbronn, Daniele Marie Leonard, Joseph Thomas Repine
  • Bicyclic inhibitors of protein farnesyl transferase
    Patent number: 6133303
    Abstract: The present invention provides compounds of Formula (I). The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula (I).
    Type: Grant
    Filed: August 2, 1999
    Date of Patent: October 17, 2000
    Assignee: Warner-Lambert Company
    Inventors: Jack Bikker, Ellen Myra Dobrusin, Annette Marian Doherty, Matthew Drowns, James Stanley Kaltenbronn, Juergen Kleinschroth, Dennis Joseph McNamara, John Quin, III, Joseph Thomas Repine, Marcin Stasiak