Patents by Inventor James Steinhardt

James Steinhardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SARS-COV-2 ANTIBODIES FOR TREATMENT AND PREVENTION OF COVID-19
    Publication number: 20240092875
    Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to the spike protein of SARS-CoV-2 and methods of using such antibodies and antigen-binding fragments thereof for the prevention and treatment of Coronavirus Disease 2019 (COVID-19) in a subject.
    Type: Application
    Filed: August 9, 2023
    Publication date: March 21, 2024
    Inventors: Robert GASSER, Mark ESSER, Patrick MCTAMNEY, II, Yueh-Ming LOO, Reena M. VARKEY, Qun DU, James STEINHARDT, Saravanan RAJAN
  • SARS-COV-2 PROTEINS, ANTI-SARS-COV-2 ANTIBODIES, AND METHODS OF USING THE SAME
    Publication number: 20230279078
    Abstract: The present disclosure provides SARS-CoV-2 spike proteins and trimers containing such spike proteins. The present disclosure also provides antibodies and antigen-binding fragments thereof that specifically bind to the spike protein of SARS-CoV-2. The proteins, trimers, and antibodies can be used, for example, to detect anti-SARS-CoV-2 antibodies in sample obtained from a subject.
    Type: Application
    Filed: July 19, 2021
    Publication date: September 7, 2023
    Inventors: GLEN HUGHES, RUTH E. MARCH, MARK ESSER, PATRICK MCTAMNEY II, YUEH-MING LOO, REENA M. VARKEY, QUN DU, JAMES STEINHARDT, SARAVANAN RAJAN
  • Multispecific Anti-HIV Antibodies
    Publication number: 20220227845
    Abstract: The present invention provides a multispecific anti-HIV antibody that binds to multiple epitopes on HIV envelope protein, wherein the antibody comprises: i. an amino acid sequence that binds to a V1/V2 apex glycan epitope; ii. an amino acid sequence that binds to a V3-base glycan region epitope; iii. an amino acid sequence that binds to a CD4 binding site (CD4bs) epitope; iv. an amino acid sequence that binds to a gp120/gp41 interface epitope; and v. an amino acid sequence that binds to a membrane proximal external region (MPER) epitope.
    Type: Application
    Filed: October 18, 2019
    Publication date: July 21, 2022
    Inventors: Yuxing Li, James Steinhardt, Javier Guenaga, John R. Mascola, Tae-Wook Chun, Susan Moir, Chi-I Chiang
  • SARS-COV-2 ANTIBODIES FOR TREATMENT AND PREVENTION OF COVID-19
    Publication number: 20220041694
    Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to the spike protein of SARS-CoV-2 and methods of using such antibodies and antigen-binding fragments thereof for the prevention and treatment of Coronavirus Disease 2019 (COVID-19) in a subject.
    Type: Application
    Filed: August 9, 2021
    Publication date: February 10, 2022
    Inventors: Robert GASSER, Mark ESSER, Patrick MCTAMNEY, II, Yueh-Ming LOO, Reena M. VARKEY, Qun DU, James STEINHARDT, Saravanan RAJAN
  • SARS-COV-2 ANTIBODIES AND METHODS OF SELECTING AND USING THE SAME
    Publication number: 20210355196
    Abstract: The present disclosure provides antibodies and antigen-binding fragments thereof that specifically bind to the spike protein of SARS-CoV-2 and methods of making and selecting the same. The antibodies can be used, for example, in prophylaxis, post-exposure prophylaxis, or treatment of SARS-CoV-2 infection. The antibodies can also be used to detect SARS-CoV-2 infection in subject.
    Type: Application
    Filed: May 17, 2021
    Publication date: November 18, 2021
    Applicant: AstraZeneca UK Limited
    Inventors: Mark ESSER, James STEINHARDT, Patrick MCTAMNEY, II, Yueh-Ming LOO, Reena M. VARKEY, Qun DU, Saravanan RAJAN
  • Multispecific antibodies targeting human immunodeficiency virus and methods of using the same
    Patent number: 11149082
    Abstract: The present disclosure relates to multispecific antibodies targeting the human immunodeficiency virus-1 (HIV-1) envelope, methods for their production, pharmaceutical compositions containing said antibodies and uses thereof in treatment and prevention of HIV infection.
    Type: Grant
    Filed: October 17, 2017
    Date of Patent: October 19, 2021
    Assignees: University of Maryland, College Park, The United States of America, As Represented By, International AIDS Vaccine Initiative
    Inventors: Javier Guenaga, Yuxing Li, James Steinhardt, John R. Mascola
  • MULTISPECIFIC ANTIBODIES TARGETING HUMAN IMMUNODEFICIENCY VIRUS AND METHODS OF USING THE SAME
    Publication number: 20200123236
    Abstract: The present disclosure relates to multispecific antibodies targeting the human immunodeficiency virus-1 (HIV-1) envelope, methods for their production, pharmaceutical compositions containing said antibodies and uses thereof in treatment and prevention of HIV infection.
    Type: Application
    Filed: October 17, 2017
    Publication date: April 23, 2020
    Inventors: Javier Guenaga, Yuxing Li, James Steinhardt, John R. Mascola