Abstract: Provided are topical antimicrobial compositions for application to the epidermis, e.g., hands, arms, legs, face, scalp as well as other body areas which are characterized in being free of conventional anionic soaps and conventional anionic surfactants, which preferably exhibits an acidic pH. The compositions exhibit at least 3 log kill efficacy, preferably at least 4 log kill efficacy at 60 seconds contact time of at least two, preferably at least three and most preferably at least four of microorganisms selected from the group consisting of: S. aureus, E. coli. P. aeruginosa and E. hirae, according to the known-art protocols EN 12054 (Chemical Disinfectants and antiseptics—Quantitative suspension test for the evaluation of antimicrobial activity), EN 1276 (Evaluation of Bactericidal Activity in Suspension—Dilution Neutralisation Method) and EN 1499 (Chemical Disinfectants and Antiseptics—Hygienic Handwash).