Abstract: Apparatuses and methods for spectroscopy using multiple resonance modes are provided. Multiple resonance modes may be used for bulk sensing and/or surface sensing applications. A plasmon waveguide resonance sensor is provided for multimode spectroscopy. The sensor includes a dielectric layer; and a metallic layer coupled to the dielectric layer. The sensor is configured to provide: a first resonance mode for bulk sensing, in response to light of a given wavelength; and a second resonance mode for surface sensing, in response to light of the given wavelength. The first and second resonance modes have different polarizations. Surface plasmon resonance assemblies are provided having a grating coupled to a surface plasmon resonance sensor, the grating being a dielectric grating or a metallic grating. The grating, in response to light, provides various resonance modes having at least two different polarizations for bulk and surface sensing.

Abstract: Apparatuses and methods for spectroscopy using multiple resonance modes are provided. Multiple resonance modes may be used for bulk sensing and/or surface sensing applications. A plasmon waveguide resonance sensor is provided for multimode spectroscopy. The sensor includes a dielectric layer; and a metallic layer coupled to the dielectric layer. The sensor is configured to provide: a first resonance mode for bulk sensing, in response to light of a given wavelength; and a second resonance mode for surface sensing, in response to light of the given wavelength. The first and second resonance modes have different polarizations. Surface plasmon resonance assemblies are provided having a grating coupled to a surface plasmon resonance sensor, the grating being a dielectric grating or a metallic grating. The grating, in response to light, provides various resonance modes having at least two different polarizations for bulk and surface sensing.

Abstract: The present invention is a method and a system of cell detection and analysis. The present invention may incorporate at least an optical source, a fluidic chip and a detection module. Cells may be caused to flow within the fluidic chip and specifically past a detection window section accessible by the optical source. The flowing cells may be identified and/or analyzed. The detection module may specifically count the cells of interest as they flow past the detection window section of the chip. The detection module may further be operable to generate or otherwise capture images of the cells as they flow past the window and to use these images collectively for the purpose of analyzing the cells. The present invention may be portable and operable in remote locations.

Abstract: An improved integrated optical device (5a-5g) is disclosed containing first and second devices (10a-10g; 15a, 15e), optically coupled to each other and formed in first and second different material systems. One of the first or second devices (10a-10g, 15a, 15e) has a Quantum Well Intermixed (QWI) region (20a, 20g) at or adjacent a coupling region between the first and second devices (10a-10g; 15a, 15e). The first material system may be a III-V semiconductor based on Gallium Arsenide (GaAs) or Indium Phosphide (InP), while the second material may be Silica (SiO2), Silicon (Si), Lithium Niobate (LiNbO3), a polymer, or glass.

Abstract: A waveguide for an optical circuit comprises a substrate; a buffer layer formed on the substrate; a doped lower cladding layer formed on the buffer layer; a doped waveguide core formed on the lower cladding layer; and a doped upper cladding layer embedding the waveguide core. The waveguide core includes mobile dopant ions which have diffused into the upper cladding layer and the lower cladding layer to form an ion diffusion region around said waveguide core such that the waveguide core boundary walls are substantially smooth. A waveguide core may be formed which is substantially symmetric about its core axis. Methods of fabricating the waveguide are also described.

Abstract: An improved integrated optical device (5a-5g) is disclosed containing first and second devices (10a-10g; 15a, 15e), optically coupled to each other and formed in first and second different material systems. One of the first or second devices (10a-10g, 15a, 15e) has a Quantum Well Intermixed (QWI) region (20a, 20g) at or adjacent a coupling region between the first and second devices (10a-10g; 15a, 15e). The first material system may be a Ill-V semiconductor based on Gallium Arsenide (GaAs) or Indium Phosphide (InP), while the second material may be Silica (SiO2), Silicon (Si), Lithium Niobate (LiNbO3), a polymer, or glass.

Abstract: This invention relates to analytical “chips” known as biochips which are integrated microstructure devices able to perform biological or chemical measurements. In particular, the invention relates to an analytical chip comprising a substrate having an array of wells arranged on the substrate for receiving a fluid and at least one waveguide positioned transversely to the wells for receiving light from said wells in response to incident light into said wells. The invention is also concerned with a method of making the analytical chips and a point-of-care system for detecting biological or non-biological molecules.