Patents by Inventor James Storhoff

James Storhoff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060068378
    Abstract: The invention provides methods of detecting a nucleic acid. The methods comprise contacting the nucleic acid with one or more types of particles having oligonucleotides attached thereto. In one embodiment of the method, the oligonucleotides are attached to nanoparticles and have sequences complementary to portions of the sequence of the nucleic acid. A detectable change (preferably a color change) is brought about as a result of the hybridization of the oligonucleotides on the nanoparticles to the nucleic acid. The invention also provides compositions and kits comprising particles. The invention further provides methods of synthesizing unique nanoparticle-oligonucleotide conjugates, the conjugates produced by the methods, and methods of using the conjugates. In addition, the invention provides nanomaterials and nanostructures comprising nanoparticles and methods of nanofabrication utilizing nanoparticles. Finally, the invention provides a method of separating a selected nucleic acid from other nucleic acids.
    Type: Application
    Filed: February 4, 2005
    Publication date: March 30, 2006
    Inventors: Chad Mirkin, Robert Letsinger, Robert Mucic, James Storhoff, Robert Elghanian, Thomas Taton, Viswanadham Garimella, Zhi Li, So-Jung Park, Gang Lu
  • Publication number: 20060014172
    Abstract: The present invention provides aptamer probes, nanoparticle-aptamer conjugate probes, aptamer arrays, methods of detecting target analytes in a sample comprising detecting binding of a target analyte with aptamer probes, method of detection, and kits.
    Type: Application
    Filed: May 3, 2005
    Publication date: January 19, 2006
    Inventors: Uwe Muller, James Storhoff, Michael Senical, Viswanadham Garimella
  • Publication number: 20050250094
    Abstract: The invention provides methods of detecting one or more specific binding analytes, such as nucleic acids and proteins, in the presence of a neutral or anionic polysaccharide, through light scattering techniques, where a change in light scattering caused by the formation of nanoparticle label complexes within the penetration depth of the evanescent wave of a wave guide signals the presence of the analyte.
    Type: Application
    Filed: November 22, 2004
    Publication date: November 10, 2005
    Inventors: James Storhoff, Adam Lucas, Uwe Muller, Yijia Bao, Michael Senical, Viswanadham Garimella
  • Publication number: 20050059030
    Abstract: The present invention provides methods for detecting a target nucleic acid molecule in a sample that comprises nucleic acid molecules of higher biological complexity than that of amplified nucleic acid molecules. In particular, the present invention provides methods and probes for detecting a single nucleotide polymorphism (SNP) in a sample that comprises nucleic acid molecules of higher biological complexity than that of amplified nucleic acid molecules.
    Type: Application
    Filed: December 12, 2003
    Publication date: March 17, 2005
    Inventors: Yijia Bao, Sudhakar Marla, Uwe Muller, James Storhoff, Susan Hetzel