Abstract: In a general aspect, a swab sample is analyzed, for example, to test for disease. In some examples, a swab head of a swab sample is inserted through an opening into an internal reservoir of a sampling device. The sampling device includes the opening, an inlet channel, an outlet channel, and the internal reservoir. The internal reservoir is in fluid communication with the inlet channel, the outlet channel, and the opening. A liquid solvent is supplied to the swab head in the internal reservoir via the inlet channel of the sampling device. The swab head is held in the liquid solvent for a period of time to form an analyte in the internal reservoir. The analyte is extracted from the internal reservoir via the outlet channel of the sampling device. The analyte is transferred to and processed by a mass spectrometer to obtain mass spectrometry data.

Abstract: Methods and apparatus are provided for cleaning or exchanging medical devices. Certain embodiments may include a cassette comprising a plurality of medical devices, where the orientation of the cassette can be changed while the cassette is coupled to a processing instrument.

Abstract: Methods and devices are provided for assessing biological samples using molecular analysis. In certain aspects, methods and devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry. In certain aspects, the results of the mass spectrometry can be analyzed to determine tissue type, sample quality, or disease state of the sample.