Abstract: The present invention relates to a method for purifying anti-IL-6 receptor antibodies from a sample comprising said antibodies and impurities, through the use of a three-chromatographic columns procedure, including a chromatography on Fluorapatite-containing resin. The invention is also concerned with pharmaceutical compositions comprising the purified antibodies obtainable by the process of the invention.

Abstract: Some embodiments of the disclosure include inventive compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain diseases. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as hematopoietic cancers, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), etc.), Additional embodiments provide disease treatment using combinations of the inventive IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies.

Abstract: The present invention relates to a method for purifying adalimumab or a biosimilar thereof from a sample comprising adalimumab or a biosimilar thereof and impurities, through the use of hydroxyapatite resin in a Bind/Elute (B/E) mode under conditions such that the adalimumab or a biosimilar thereof binds to the resin and at least a portion of the impurities remain unbound. The invention is also concerned with a pharmaceutical compositions=of the purified adalimumab or a biosimilar thereof, and adalimumab or a biosimilar thereof obtainable by the process of the invention.

Abstract: The technology generally relates to spatial audio communication between devices. For example, a first device and a second device may be connected via a communication link. The first device may capture audio signals in an environment through two or more microphones. The first device may encode the captured audio with spatial configuration data. The first device may transmit the encoded audio via the communication link to the second device. The second device may decode the encoded audio into binaural or ambisonic audio to be output by one or more speakers of the second device. The binaural or ambisonic audio may be converted into spatial audio to be output. The second device may output the binaural or spatial audio to create an immersive listening experience.

Abstract: The present invention relates to a method for purifying proteins, such as Fc fusion proteins or antibodies, from a sample comprising said proteins and impurities, through the use of a three-chromatographic columns procedure, including a chromatography on hydroxyapatite- and/or Fluorapatite-containing material. The invention is also concerned with pharmaceutical compositions comprising the purified proteins obtainable by the process of the invention.

Abstract: The present invention relates to a method for purifying anti-IL-6 receptor antibodies from a sample comprising said antibodies and impurities, through the use of a three-chromatographic columns procedure, including a chromatography on Fluorapatite-containing resin. The invention is also concerned with pharmaceutical compositions comprising the purified antibodies obtainable by the process of the invention.

Abstract: An industrial control system provides for a bottom-up configuration and incremental growth in size and complexity without requiring system-specific programming at a central control or display point. XML packets are transmitted from the controllers upon event occurrences and controllers are assigned human meaningful names and group names. By knowing the addressing information for a single controller in a named group of controllers, the identity, addressing and basic status for other members of the group are provided graphically. This can allow operation in a low-bandwidth environment, including LTE cellular communications.

Abstract: A pseudo-active chemical imaging sensor including irradiative transient heating, temperature nonequilibrium thermal luminescence spectroscopy, differential hyperspectral imaging, and artificial neural network technologies integrated together. The sensor may be applied to the terrestrial chemical contamination problem, where the interstitial contaminant compounds of detection interest (analytes) comprise liquid chemical warfare agents, their various derivative condensed phase compounds, and other material of a life-threatening nature. The sensor measures and processes a dynamic pattern of absorptive-emissive middle infrared molecular signature spectra of subject analytes to perform its chemical imaging and standoff detection functions successfully.