Abstract: An apparatus with an integrated circuit (IC) chip can provide protection against attacks on a read-only memory (ROM), such as a boot ROM for security circuitry. An attacker can gain control of an IC by modifying ROM contents and/or redirecting ROM reads. To combat these attacks, example implementations store encrypted ROM data in the ROM array. A ROM controller is used to cryptographically tie the address of each ROM line to the corresponding encrypted ROM datum. To access the encrypted ROM datum, cryptographic circuitry decrypts the encrypted ROM datum using a key that is generated based on the corresponding ROM address. As part of an integrity checking procedure, a digest can be computed based on the encrypted ROM data. To further thwart would-be attacks, the ROM address can be adjusted (e.g., scrambled) before the controller uses the adjusted address to read encrypted data from the ROM array.

Abstract: An apparatus with an integrated circuit (IC) chip can provide protection against attacks on a cryptographic coprocessor. An attacker can compromise a cryptographic coprocessor by, for instance, obtaining a private encryption key or instruction code. To combat these attacks, example implementations store information in encrypted form. The information may correspond to data, instruction code, or intermediate values located in state registers. To securely and quickly “erase” such stored information, the cryptographic coprocessor can change the encryption key. In other example implementations, random numbers are provided with two different levels of “randomness quality” that is appropriate for different types of procedures. A cryptographic coprocessor can include two registers that store randomized bits in accordance with the two different quality levels for rapid access during cryptographic operations.

Abstract: An apparatus with an integrated circuit (IC) chip can provide protection against attacks on a read-only memory (ROM), such as a boot ROM for security circuitry. An attacker can gain control of an IC by modifying ROM contents and/or redirecting ROM reads. To combat these attacks, example implementations store encrypted ROM data in the ROM array. A ROM controller is used to cryptographically tie the address of each ROM line to the corresponding encrypted ROM datum. To access the encrypted ROM datum, cryptographic circuitry decrypts the encrypted ROM datum using a key that is generated based on the corresponding ROM address. As part of an integrity checking procedure, a digest can be computed based on the encrypted ROM data. To further thwart would-be attacks, the ROM address can be adjusted (e.g., scrambled) before the controller uses the adjusted address to read encrypted data from the ROM array.

Abstract: The present invention relates to pharmaceutical formulations for the controlled delivery of threo-3-(3,4-dihydroxyphenyl)serine (threo-DOPS) and derivatives of it. Such formulations can contain an extended or slow release component that maintains therapeutic concentration of threo-DOPS in the blood plasma over a prolonged time period. They can be further combined with an immediate release formulation to produce a product that, when administered to a patient in need thereof, results in substantially steady levels of active drug, eliminating the sharp peaks and troughs in blood plasma drug levels experienced with the existing threo-DOPS formulations.

Abstract: The present invention relates to pharmaceutical formulations for the controlled delivery of threo-3-(3,4-dihydroxyphenyl)serine (threo-DOPS) and derivatives of it. Such formulations can contain an extended or slow release component that maintains therapeutic concentration of threo-DOPS in the blood plasma over a prolonged time period. They can be further combined with an immediate release formulation to produce a product that, when administered to a patient in need thereof, results in substantially steady levels of active drug, eliminating the sharp peaks and troughs in blood plasma drug levels experienced with the existing threo-DOPS formulations.

Abstract: The present invention relates to pharmaceutical formulations for the controlled delivery of threo-3-(3,4-dihydroxyphenyl)serine (threo-DOPS) and derivatives of it. Such formulations can contain an extended or slow release component that maintains therapeutic concentration of threo-DOPS in the blood plasma over a prolonged time period. They can be further combined with an immediate release formulation to produce a product that, when administered to a patient in need thereof, results in substantially steady levels of active drug, eliminating the sharp peaks and troughs in blood plasma drug levels experienced with the existing threo-DOPS formulations.

Abstract: The present invention relates to pharmaceutical formulations for the controlled delivery of threo-3-(3,4-dihydroxyphenyl)serine (threo-DOPS) and derivatives of it. Such formulations can contain an extended or slow release component that maintains therapeutic concentration of threo-DOPS in the blood plasma over a prolonged time period. They can be further combined with an immediate release formulation to produce a product that, when administered to a patient in need thereof, results in substantially steady levels of active drug, eliminating the sharp peaks and troughs in blood plasma drug levels experienced with the existing threo-DOPS formulations.

Abstract: The present invention relates to pharmaceutical formulations for the controlled delivery of threo-3-(3,4-dihydroxyphenyl)serine (threo-DOPS) and derivatives of it. Such formulations can contain an extended or slow release component that maintains therapeutic concentration of threo-DOPS in the blood plasma over a prolonged time period. They can be further combined with an immediate release formulation to produce a product that, when administered to a patient in need thereof, results in substantially steady levels of active drug, eliminating the sharp peaks and troughs in blood plasma drug levels experienced with the existing threo-DOPS formulations.

Abstract: The present invention relates to pharmaceutical formulations for the controlled delivery of threo-3-(3,4-dihydroxyphenyl)serine (threo-DOPS) and derivatives of it. Such formulations can contain an extended or slow release component that maintains therapeutic concentration of threo-DOPS in the blood plasma over a prolonged time period. They can be further combined with an immediate release formulation to produce a product that, when administered to a patient in need thereof, results in substantially steady levels of active drug, eliminating the sharp peaks and troughs in blood plasma drug levels experienced with the existing threo-DOPS formulations.

Abstract: Disclosed are pharmaceutical compositions comprising an active vitamin D compound in emulsion pre-concentrate formulations, as well as emulsions and sub-micron droplet emulsions produced therefrom. The compositions comprise a lipophilic phase component, one or more surfactants, and an active vitamin D compound. The compositions may optionally further comprise a hydrophilic phase component.

Abstract: The present invention relates to pharmaceutical formulations for the controlled delivery of threo-3-(3,4-dihydroxyphenyl)serine (threo-DOPS) and derivatives of it. Such formulations can contain an extended or slow release component that maintains therapeutic concentration of threo-DOPS in the blood plasma over a prolonged time period. They can be further combined with an immediate release formulation to produce a product that, when administered to a patient in need thereof, results in substantially steady levels of active drug, eliminating the sharp peaks and troughs in blood plasma drug levels experienced with the existing threo-DOPS formulations.

Abstract: Disclosed are pharmaceutical compositions comprising an active vitamin D compound in emulsion pre-concentrate formulations, as well as emulsions and sub-micron droplet emulsions produced therefrom. The compositions comprise a lipophilic phase component, one or more surfactants, and an active vitamin D compound. The compositions may optionally further comprise a hydrophilic phase component.

Abstract: Disclosed are pharmaceutical compositions comprising an active vitamin D compound in emulsion pre-concentrate formulations, as well as emulsions and sub-micron droplet emulsions produced therefrom. The compositions comprise a lipophilic phase component, one or more surfactants, and an active vitamin D compound. The compositions may optionally further comprise a hydrophilic phase component.

Abstract: A process for making pharmaceutical dosage units containing a therapeutic quantity of one or more low dosage medicinal agent comprising granulating said medicinal agent in an aqueous medium which contains a pharmaceutically acceptable surfactant agent and, optionally, further processing the product of said granulating into a tablet or capsule dosage unit.

Abstract: Disclosed is a method of dry blend compression of potent drugs with low solubility, such as steroidal medicaments using directly compressible agglomerated excipients that are not a conventional or spray dried polyalcohol or lactose. The agglomerated excipients include mannitol, maltodextrin or corn syrup solids, which hold the medicament(s) in the crevices of the agglomerates. Also disclosed are the critical ratios of the agglomerated excipients to steroidal agent, specifically estradiol, that is distributed uniformly throughout the dry blend and then compressed into tablets.

Abstract: The present invention provides pharmaceutical capsule compositions for the oral administration of an H.sub.2 -antagonist. The composition includes a capsule containing an emulsion having a water portion and an oil portion. A pharmaceutically acceptable salt of an H.sub.2 -antagonist is dissolved in the water portion. The composition delivers a therapeutically effective amount of the H.sub.2 -antagonist to a patient in need thereof. The present invention also provides methods of making the capsule composition.

Abstract: The time during which a drug is pharmacologically active is prolonged by coating the drug with at least one chemical derivative of the drug having minor relative pharmacological activity.

Abstract: The time during which a drug is pharmacologically active is prolonged by coating the drug with at least one chemical derivative of the drug having minor relative pharmacological activity.