Patents by Inventor James T. Dalton

James T. Dalton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methylene-bridged selective androgen receptor modulators and methods of use thereof
    Patent number: 7253210
    Abstract: This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: August 7, 2007
    Assignee: University of Tennessee Research Foundation
    Inventors: James T. Dalton, Duane D. Miller, Igor Rakov
  • Heterocyclic selective androgen receptor modulators and methods of use thereof
    Patent number: 7214693
    Abstract: This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor.
    Type: Grant
    Filed: October 14, 2003
    Date of Patent: May 8, 2007
    Assignee: University of Tennessee Research Foundation
    Inventors: James T. Dalton, Duane D. Miller
  • Selective androgen receptor modulators
    Patent number: 7205437
    Abstract: The present invention relates to androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity, which are nonsteroidal ligands for the androgen receptor.
    Type: Grant
    Filed: May 10, 2005
    Date of Patent: April 17, 2007
    Assignee: University of Tennessee Research Foundation
    Inventors: James T. Dalton, Duane D. Miller, Yali He, Donghua Yin
  • Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
    Patent number: 7129377
    Abstract: The present invention relates to an androgen receptor alkylating compound, wherein the compound may include, inter alia, an active functional group, which permits the alkylation of the androgen receptor.
    Type: Grant
    Filed: July 6, 2004
    Date of Patent: October 31, 2006
    Assignee: University of Tennessee Research Foundation
    Inventors: Duane D. Miller, Leonid I. Kirkovsky, James T. Dalton, Arnab Mukherjee
  • Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
    Patent number: 7041844
    Abstract: The present invention relates to an antiandrogen compound and a method of treating prostate cancer in a patient utilizing the compound. The present invention also relates to a pharmaceutical composition which includes the compound.
    Type: Grant
    Filed: November 18, 2002
    Date of Patent: May 9, 2006
    Assignee: The University Of Tennessee Research Corporation
    Inventors: Duane D. Miller, Leonid I. Kirkovsky, James T. Dalton, Arnab Mukherjee
  • Halogenated selective androgen receptor modulators and methods of use thereof
    Patent number: 7026500
    Abstract: This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor.
    Type: Grant
    Filed: February 24, 2003
    Date of Patent: April 11, 2006
    Assignee: University of Tennessee Research Foundation
    Inventors: James T. Dalton, Duane D. Miller, Mitchell S. Steiner, Karen A. Veverka
  • N-bridged selective androgen receptor modulators and methods of use thereof
    Patent number: 7022870
    Abstract: This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor.
    Type: Grant
    Filed: June 17, 2003
    Date of Patent: April 4, 2006
    Assignee: University of Tennessee Research Foundation
    Inventors: James T. Dalton, Duane D. Miller, Craig A. Marhefka, Wenqing Gao
  • Selective androgen receptor modulators and methods of use thereof
    Patent number: 6998500
    Abstract: This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor.
    Type: Grant
    Filed: October 16, 2002
    Date of Patent: February 14, 2006
    Assignee: University of Tennessee Research Foundation
    Inventors: James T. Dalton, Duane D. Miller, Yali He, Donghua Yin
  • Synthesis of selective androgen receptor modulators
    Patent number: 6995284
    Abstract: The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor.
    Type: Grant
    Filed: October 22, 2002
    Date of Patent: February 7, 2006
    Assignee: The University of Tennessee Research Foundation
    Inventors: James T. Dalton, Duane D. Miller, Yali He, Donghua Yin
  • LPA receptor agonists and antagonists and methods of use
    Patent number: 6875757
    Abstract: The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, and treating a wound.
    Type: Grant
    Filed: March 19, 2001
    Date of Patent: April 5, 2005
    Assignee: University of Tennessee Research Foundation
    Inventors: Duane D. Miller, Gabor Tigyi, James T. Dalton, Vineet M. Sardar, Don B. Elrod, Huiping Xu, Daniel L. Baker, Dean Wang, Karoly Liliom, David J. Fischer, Tamas Virag, Nora Nusser
  • Formulations comprising selective androgen receptor modulators
    Patent number: 6838484
    Abstract: The present invention relates to pharmaceutical compositions and formulations comprising a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: January 4, 2005
    Assignee: University of Tennessee Research Foundation
    Inventors: Mitchell S. Steiner, Karen A. Veverka, James T. Dalton, Duane D. Miller, Yali He, Donghua Yin
  • Method for detecting selective androgen receptor modulators
    Publication number: 20040265916
    Abstract: The present invention relates to analytical methods for detecting, identifying characterizing, purifying, obtaining structural information on, qualifying, screening, separating, fractionating and/or quantifying a Selective Androgen Receptor Modulator (SARM) compound in a sample, by obtaining a sample, and detecting the presence and/or concentration of a SARM compound in the sample. The methods of the present invention are highly robust, sensitive, specific, reliable, validated, validatable and reproducible assays that are of great commercial potential and value.
    Type: Application
    Filed: March 15, 2004
    Publication date: December 30, 2004
    Inventors: James T. Dalton, Duane D. Miller, Karen A. Veverka
  • Metabolites of selective androgen receptor modulators and methods of use thereof
    Publication number: 20040260108
    Abstract: This invention provides metabolites of a class of androgen receptor targeting agents (ARTA).
    Type: Application
    Filed: May 20, 2004
    Publication date: December 23, 2004
    Inventors: James T. Dalton, Duane D. Miller, Donghua Yin, Yali He
  • Irreversible non-steroidal antagonist compound and its use in the treatment of prostate cancer
    Publication number: 20040248862
    Abstract: The present invention relates to an androgen receptor alkylating compound, wherein the compound may include, inter alia, an active functional group, which permits the alkylation of the androgen receptor.
    Type: Application
    Filed: July 6, 2004
    Publication date: December 9, 2004
    Inventors: Duane D. Miller, Leonid I. Kirkovsky, James T. Dalton, Arnab Mukherjee
  • Treating obesity with selective androgen receptor modulators
    Publication number: 20040224979
    Abstract: This invention relates to the prevention and treatment of obesity.
    Type: Application
    Filed: October 14, 2003
    Publication date: November 11, 2004
    Inventors: James T. Dalton, Duane D. Miller, Mitchell S. Steiner, Karen A. Veverka, Jiyun Chen
  • Method for detecting selective androgen receptor modulators
    Publication number: 20040197928
    Abstract: The present invention relates to analytical methods for detecting, identifying characterizing, purifying, obtaining structural information on, qualifying, screening, separating, fractionating and/or quantifying a Selective Androgen Receptor Modulator (SARM) compound in a sample, by obtaining a sample, and detecting the presence and/or concentration of a SARM compound in the sample. The methods of the present invention are highly robust, sensitive, specific, reliable, validated, validatable and reproducible assays that are of great commercial potential and value.
    Type: Application
    Filed: October 14, 2003
    Publication date: October 7, 2004
    Inventors: James T. Dalton, Duane D. Miller, Karen A. Veverka
  • Haloacetamide and azide substituted compounds and methods of use thereof
    Publication number: 20040167103
    Abstract: The present invention relates to a novel class of androgen receptor targeting agents (ARTA), which contain a haloacetamide or azide moiety and are alkylating agents.
    Type: Application
    Filed: July 10, 2003
    Publication date: August 26, 2004
    Inventors: James T. Dalton, Duane D. Miller, Huiping Xu, Vipin Nair
  • Methylene-bridged selective androgen receptor modulators and methods of use thereof
    Publication number: 20040147550
    Abstract: This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor.
    Type: Application
    Filed: October 14, 2003
    Publication date: July 29, 2004
    Inventors: James T. Dalton, Duane D. Miller, Igor Rakov
  • Haloacetamide and azide substituted compounds and methods of use thereof
    Publication number: 20040147489
    Abstract: The present invention relates to a novel class of androgen receptor targeting agents (ARTA), which contain a haloacetamide or azide moiety and are alkylating agents.
    Type: Application
    Filed: February 24, 2003
    Publication date: July 29, 2004
    Inventors: James T. Dalton, Duane D. Miller
  • Heterocyclic selective androgen receptor modulators and methods of use thereof
    Publication number: 20040138244
    Abstract: This invention provides a class of androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor.
    Type: Application
    Filed: October 14, 2003
    Publication date: July 15, 2004
    Inventors: James T. Dalton, Duane D. Miller