Patents by Inventor James T. Kadonaga

James T. Kadonaga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optimized core promoters and uses thereof
    Patent number: 7968698
    Abstract: The present invention provides core promoter motif ten elements (MTE) and core promoter constructs comprising the MTEs and an initiator element (Inr) in combination with one or both of a TATA box and a downstream promoter element (DPE) which increases gene expression over the strongest known core promoters. Particularly, an optimized or super core promoter is provided which comprises Inr, MTE, TATA box and DPE elements. The present invention also provides expression vectors and host cells comprising the core promoter constructs. Additionally, methods of increasing production of a protein using the core promoter constructs are provided.
    Type: Grant
    Filed: May 25, 2006
    Date of Patent: June 28, 2011
    Assignee: The Regents of the University of California
    Inventors: James T. Kadonaga, Tamar Gershon
  • Optimized core promoters and uses thereof
    Publication number: 20100129863
    Abstract: The present invention provides core promoter motif ten elements (MTE) and core promoter constructs comprising the MTEs and an initiator element (Inr) in combination with one or both of a TATA box and a downstream promoter element (DPE) which increases gene expression over the strongest known core promoters. Particularly, an optimized or super core promoter is provided which comprises Inr, MTE, TATA box and DPE elements. The present invention also provides expression vectors and host cells comprising the core promoter constructs. Additionally, methods of increasing production of a protein using the core promoter constructs are provided.
    Type: Application
    Filed: May 25, 2006
    Publication date: May 27, 2010
    Inventor: James T Kadonaga