Patents by Inventor James T. Kealey

James T. Kealey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ACYL ACTIVATING ENZYMES FOR PREPARATION OF CANNABINOIDS
    Publication number: 20240117388
    Abstract: Enzymes and recombinant host cells for the biosynthesis of clinically important prenylated polyketides of the cannabinoid family are provided. Using readily available starting materials, heterologous enzymes (e.g., bacterial CoA-transferases and CoA-ligases) are used to direct cannabinoid biosynthesis in host cells such as recombinant yeast cells.
    Type: Application
    Filed: January 20, 2022
    Publication date: April 11, 2024
    Inventors: James T. KEALEY, James P. CRAIG, Jianping SUN, Charles K. MARLOWE, Colin W. JOHNSON, Philip J. BARR
  • GENETICALLY MODIFIED YEAST FOR THE PRODUCTION OF CANNABIGEROLIC ACID, CANNABICHROMENIC ACID AND RELATED CANNABINOIDS
    Publication number: 20230063396
    Abstract: The present invention relates generally to production methods, enzymes and recombinant yeast strains for the biosynthesis of clinically important cannabinoid compounds.
    Type: Application
    Filed: January 20, 2021
    Publication date: March 2, 2023
    Inventors: Philip J. Barr, Jianping SUN, James T. KEALEY, Charles MARLOWE, James P. CRAIG, Colin W. JOHNSON
  • CANNABINOID ANALOGS AND METHODS FOR THEIR PREPARATION
    Publication number: 20210403408
    Abstract: Provided herein are cannabinoid analogs, including halogenated cannabinoid analogs, hydroxylated cannabinoid analogs, deuterated cannabinoid analogs, and tritiated cannabinoid analogs. The cannabinoid analogs can be prepared by partial or total expression in modified host cells, such as recombinantly modified yeast cells, optionally in combination with chemical synthetic steps.
    Type: Application
    Filed: October 31, 2019
    Publication date: December 30, 2021
    Inventors: Philip J. BARR, Charles K. MARLOWE, Jianping SUN, James T. KEALEY
  • USE OF TYPE I AND TYPE II POLYKETIDE SYNTHASES FOR THE PRODUCTION OF CANNABINOIDS AND CANNABINOID ANALOGS
    Publication number: 20210403959
    Abstract: The present invention relates generally to production methods, enzymes and recombinant yeast strains for the biosynthesis of clinically important prenylated polyketides of the cannabinoid family. Using readily available starting materials, heterologous enzymes are used to direct cannabinoid biosynthesis in yeast.
    Type: Application
    Filed: November 13, 2019
    Publication date: December 30, 2021
    Inventors: Philip J. BARR, Charles K. MARLOWE, Jianping SUN, James T. Kealey
  • Inhibitory polynucleotides directed against the RNA component of telomerase
    Patent number: 7585966
    Abstract: This invention provides inhibitory polynucleotides, such as antisense molecules, directed against accessible regions in the telomerase ribonucleoprotein. The polynucleotides are useful for inhibiting the activity of telomerase in cells and for treating cancer.
    Type: Grant
    Filed: November 8, 1999
    Date of Patent: September 8, 2009
    Assignee: Geron Corporation
    Inventors: James T. Kealey, Ronald Pruzan, Scott L. Weinrich
  • Recombinant host cells expressing atoAD and capable of making a polyketide using a starter unit
    Patent number: 7413878
    Abstract: Host cells, such as E. coli, are provided with an expression system for making starter units required for biosynthesis of polyketides using the ato pathway.
    Type: Grant
    Filed: July 15, 2003
    Date of Patent: August 19, 2008
    Assignee: Kosan Biosciences, Inc.
    Inventors: James T. Kealey, Linda C. Dayem, Daniel V. Santi
  • Metabolic pathways for starter units in polyketide biosynthesis
    Publication number: 20040096946
    Abstract: Host cells, such as E. coli, are provided with an expression system for making starter units required for biosynthesis of polyketides using the ato pathway.
    Type: Application
    Filed: July 15, 2003
    Publication date: May 20, 2004
    Inventors: James T. Kealey, Linda C. Dayem, Daniel V. Santi
  • Production of polyketides in plants
    Publication number: 20020002712
    Abstract: The present invention provides genetically altered plants and plant cells that have been modified to contain expression system(s) capable of expressing a functional polyketide synthase (PKS). The present invention further provides methods of producing PKS and polyketides using these plants and cells.
    Type: Application
    Filed: May 1, 2001
    Publication date: January 3, 2002
    Inventors: Mary C. Betlach, James T. Kealey, Neal Gutterson, Ed Ralston
  • Production of polyketides in plants
    Patent number: 6262340
    Abstract: The present invention provides genetically altered plants and plant cells that have been modified to contain expression system(s) capable of expressing a functional polyketide synthase (PKS). The present invention further provides methods of producing PKS and polyketides using these plants and cells.
    Type: Grant
    Filed: July 10, 1998
    Date of Patent: July 17, 2001
    Assignee: Kosan Biosciences, Inc.
    Inventors: Mary C. Betlach, James T. Kealey, Neal Gutterson, Ed Ralston
  • Purified telomerose
    Patent number: 6261556
    Abstract: This invention provides purified human telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of a first matrix that binds molecules bearing negative charges, a matrix that binds molecules bearing positive charges, a second matrix that binds molecules bearing negative charges, an affinity purification step and a matrix that separates molecules according to their size.
    Type: Grant
    Filed: October 18, 1999
    Date of Patent: July 17, 2001
    Assignee: Geron Corporation
    Inventors: Scott L. Weinrich, Edward M. Atkinson, III, Serge P. Lichtsteiner, Alain P. Vasserot, Ronald A. Pruzan, James T. Kealey
  • Purified telomerase
    Patent number: 5968506
    Abstract: This invention provides purified human telomerase and methods of purifying it. The methods involve the use of several sequential steps, including the use of a first matrix that binds molecules bearing negative charges, a matrix that binds molecules bearing positive charges, a second matrix that binds molecules bearing negative charges, an affinity purification step and a matrix that separates molecules according to their size.
    Type: Grant
    Filed: April 4, 1997
    Date of Patent: October 19, 1999
    Assignee: Geron Corporation
    Inventors: Scott L. Weinrich, Edward M. Atkinson, III, Serge P. Lichtsteiner, Alain P. Vasserot, Ronald A. Pruzan, James T. Kealey
  • Methods for detecting the RNA component of telomerase
    Patent number: 5846723
    Abstract: Methods of detecting the RNA component of telomerase, diagnosing cancer, and determining its prognosis using polynucleotides that hybridize to the RNA component of mammalian telomerase in a sample.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: December 8, 1998
    Assignee: Geron Corporation
    Inventors: Nam Woo Kim, Fred Wu, James T. Kealey, Ronald Pruzan, Scott L. Weinrich