Patents by Inventor James T. Kurnick

James T. Kurnick has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of Anchoring or Reconstituting Active Molecules on Metabolically Labeled Cells
    Publication number: 20240016933
    Abstract: The present disclosure provides methods of anchoring active molecules on the surface of a cell, methods of anchoring at least two active molecules on the surface of a cell, and methods of enhancing an immune response to a target cell in a human.
    Type: Application
    Filed: November 5, 2021
    Publication date: January 18, 2024
    Inventors: James T. Kurnick, Ian Seymour Dunn, Matthew M. Lawler
  • METHODS OF DETERMINING SURFACE GLYCAN DENSITY
    Publication number: 20240002908
    Abstract: The present disclosure provides methods of determining surface glycan density of a cell.
    Type: Application
    Filed: November 5, 2021
    Publication date: January 4, 2024
    Inventors: James T. Kurnick, Ian Seymour Dunn, Matthew M. Lawler
  • Antibodies and Single-Chain Variable Region Proteins Recognizing Click Products
    Publication number: 20240002536
    Abstract: The present disclosure is directed, at least in part, to click-product binding molecules for recognition of templated assembly products defined by bioorthogonal click groups. Such molecules can be used for therapeutic and diagnostic purposes, including kits for the same.
    Type: Application
    Filed: November 5, 2021
    Publication date: January 4, 2024
    Inventors: James T. Kurnick, Ian Seymour Dunn, Matthew M. Lawler
  • Template Assembly by Proximity-Enhanced Reactivity via Metabolic Labeling
    Publication number: 20230414764
    Abstract: The present disclosure provides methods of metabolically labeling cells to provide a substrate for assembly of desired molecules, and to bifunctional compounds used in such methods.
    Type: Application
    Filed: November 5, 2021
    Publication date: December 28, 2023
    Inventors: James T. Kurnick, Ian Seymour Dunn, Matthew M. Lawler
  • Bifunctional Compounds And Methods Of Using The Same
    Publication number: 20230406839
    Abstract: The present disclosure provides bifunctional compounds and methods of labeling a cell having an azide-modified sugar on its surface by contacting the cell with a bifunctional compound.
    Type: Application
    Filed: November 5, 2021
    Publication date: December 21, 2023
    Inventors: James T. Kurnick, Ian Seymour Dunn, Matthew M. Lawler
  • METHODS, COMPOSITIONS, AND KITS FOR THE TREATMENT OF CANCER
    Publication number: 20140335050
    Abstract: The invention features methods, compositions, and kits for the administration of an HSP90 inhibitor, OBAA, flunarizine, aphidicolin, damnacanthal, dantrolene, or an analog thereof, alone, or in combination with, e.g., a TAA, an antigen-binding scaffold (e.g., an antibody, a soluble T cell receptor, or a chimeric receptor) specific for a TAA, a cell (e.g., a white blood cell that targets a cancer cell), and/or an IFN-? receptor agonist or an IFN-? receptor agonist, for the treatment of cancer.
    Type: Application
    Filed: May 25, 2012
    Publication date: November 13, 2014
    Applicants: The General Hospital Corporation, CytoCure LLC
    Inventors: Timothy J. Haggerty, James T. Kurnick, Ian S. Dunn
  • METHODS FOR UP-REGULATING ANTIGEN EXPRESSION IN TUMORS
    Publication number: 20120195855
    Abstract: The invention provides methods of modulating tumor antigen associated (TAA) expression, and methods of modulating TAA expression in order to treat a tumor. More particularly, the invention provides methods of increasing an immune response against a tumor cell. Methods include administering to a subject with a tumor an amount of IFN-? receptor agonist and tumor associated antigen (TAA) sufficient to increase an immune response against the tumor cell.
    Type: Application
    Filed: October 19, 2011
    Publication date: August 2, 2012
    Applicant: CytoCure LLC
    Inventors: Paul J. Durda, James T. Kurnick, Ian S. Dunn
  • Methods for up-regulating antigen expression in tumors
    Patent number: 8071321
    Abstract: The invention provides methods of modulating tumor antigen associated (TAA) expression, and methods of modulating TAA expression in order to treat a tumor. More particularly, the invention provides methods of increasing an immune response against a tumor cell. Methods include administering to a subject with a tumor an amount of IFN-? receptor agonist and tumor associated antigen (TAA) sufficient to increase an immune response against the tumor cell.
    Type: Grant
    Filed: August 29, 2003
    Date of Patent: December 6, 2011
    Assignee: CytoCure LLC
    Inventors: Paul Durda, James T. Kurnick, Ian S. Dunn
  • Methods for up-regualting antigen expression of tumors
    Publication number: 20040253235
    Abstract: The invention provides methods of modulating tumor antigen associated (TAA) expression, and methods of modulating TAA expression in order to treat a tumor. More particularly, the invention provides methods of increasing an immune response against a tumor cell. Methods include administering to a subject with a tumor an amount of IFN-&bgr; receptor agonist and tumor associated antigen (TAA) sufficient to increase an immune response against the tumor cell.
    Type: Application
    Filed: August 29, 2003
    Publication date: December 16, 2004
    Inventors: Paul Durda, James T. Kurnick, Ian S. Dunn
  • Outer membrane protein A, peptidoglycan-associated lipoprotein, and murein lipoprotein as therapeutic targets for treatment of sepsis
    Publication number: 20030017162
    Abstract: The present invention relates to three outer membrane proteins conserved among Gram-negative bacteria, OmpA, PAL, and MLP. The invention provides vaccines and polypeptides useful for passive and active immunization against Gram-negative bacteria, as well as methods of preventing and treating Gram-negative sepsis.
    Type: Application
    Filed: March 13, 2002
    Publication date: January 23, 2003
    Inventors: H. Shaw Warren, Judith Hellman, James T. Kurnick