Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: A street sweeping broom includes a helically formed brush strip which is tightly secured about the periphery of a rigid cylindrical core. The brush strip is of conventional construction including a plurality of reversely bent bristles with the bights thereof being maintained within a channel member by an anchoring wire and by crimping the sides of the channel member at spaced locations along the length thereof. At least one end of the helical brush strip is secured to a guide member which also secures the coil directly adjacent to the end of the brush strip so that the end coil thereof may not change diameter. A ring having a plurality of circumferentially spaced slots is secured to the end of the cylindrical core and the guide member is mounted on the ring in a fashion which allows movement of the guide member about the circumference of the ring in one rotational direction only.

Abstract: The brush segments of a gutter broom have self-locking lugs that are received in holes in the broom's drive plate to mount the segments. Dogs of the segments spring into at least some of the holes to keep the segments from unlocking.