Patents by Inventor James T. Murai
James T. Murai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20140349396Abstract: Aspects of the present invention include methods and compositions related to the production and use of clonal lineages of embryonic progenitor cell lines derived from differentiating cultures of primordial stem cells. In particular, said methods and compositions relate to methods of differentiating cells in the presence of agents that inhibit the signaling of the TGF beta family members of growth factors and the applications of said cell lines in the treatment of diseases such as degenerative muscle disorders, cancer, and vascular disease.Type: ApplicationFiled: September 10, 2012Publication date: November 27, 2014Inventors: Michael West, James T Murai, Jay Yang
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Patent number: 8349620Abstract: A homogeneous immunoassay method and system for quantitative determination of total immunoglobulin E and specific antibody levels to a plurality of allergens, in which a relatively small sampling of blood is required. The method utilizes relatively small microparticles in aqueous suspension. The immunoassay procedure is an immunometric sandwich procedure preferably utilizing biotin-streptavidin signal amplification techniques and R-phycoerytherin fluorescent labels.Type: GrantFiled: December 6, 2011Date of Patent: January 8, 2013Assignee: ImmuneTech, Inc.Inventors: Christopher R. Brown, James T. Murai
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Publication number: 20120264230Abstract: An allergy testing method based on a highly sensitive testing of a small blood sample is provided. The method includes collecting a blood sample from a subject, the blood sample being limited to a volume taken from a skin-prick; and, testing serum from the blood sample without dilution for an allergic response of the subject to one or more allergens, the testing having a high detection sensitivity ranging from about 10?-9 g/ml to about 10?-12 g/ml.Type: ApplicationFiled: December 22, 2011Publication date: October 18, 2012Inventors: CHRISTOPHER R. BROWN, James T. Murai
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Publication number: 20120077286Abstract: A homogeneous immunoassay method and system for quantitative determination of total immunoglobulin E and specific antibody levels to a plurality of allergens, in which a relatively small sampling of blood is required. The method utilizes relatively small microparticles in aqueous suspension. The immunoassay procedure is an immunometric sandwich procedure preferably utilizing biotin-streptavidin signal amplification techniques and R-phycoerytherin fluorescent labels.Type: ApplicationFiled: December 6, 2011Publication date: March 29, 2012Inventors: Christopher R. Brown, James T. Murai
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Patent number: 8093066Abstract: A homogeneous immunoassay method and system for quantitative determination of total immunoglobulin E and specific antibody levels to a plurality of allergens, in which a relatively small sampling of blood is required. The method utilizes relatively small microparticles in aqueous suspension. The immunoassay procedure is an immunometric sandwich procedure preferably utilizing biotin-streptavidin signal amplification techniques and R-phycoerytherin fluorescent labels.Type: GrantFiled: January 13, 2011Date of Patent: January 10, 2012Assignee: ImmuneTech, Inc.Inventors: Christopher R. Brown, James T. Murai
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Patent number: 8034632Abstract: A homogeneous immunoassay method and system for quantitative determination of total immunoglobulin E and specific antibody levels to a plurality of allergens, in which a relatively small sampling of blood is required. The method utilizes relatively small microparticles in aqueous suspension. The immunoassay procedure is an immunometric sandwich procedure preferably utilizing biotin-streptavidin signal amplification techniques and R-phycoerytherin fluorescent labels.Type: GrantFiled: January 13, 2011Date of Patent: October 11, 2011Assignee: ImmuneTech, Inc.Inventors: Christopher R. Brown, James T. Murai
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Patent number: 8034631Abstract: A homogeneous immunoassay method and system for quantitative determination of total immunoglobulin E and specific antibody levels to a plurality of allergens, in which a relatively small sampling of blood is required. The method utilizes relatively small microparticles in aqueous suspension. The immunoassay procedure is an immunometric sandwich procedure preferably utilizing biotin-streptavidin signal amplification techniques and R-phycoerytherin fluorescent labels.Type: GrantFiled: January 13, 2011Date of Patent: October 11, 2011Assignee: ImmuneTech, Inc.Inventors: Christopher R. Brown, James T. Murai
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Publication number: 20110111530Abstract: A homogeneous immunoassay method and system for quantitative determination of total immunoglobulin E and specific antibody levels to a plurality of allergens, in which a relatively small sampling of blood is required. The method utilizes relatively small microparticles in aqueous suspension. The immunoassay procedure is an immunometric sandwich procedure preferably utilizing biotin-streptavidin signal amplification techniques and R-phycoerytherin fluorescent labels.Type: ApplicationFiled: January 13, 2011Publication date: May 12, 2011Inventors: CHRISTOPHER R. BROWN, James T. Murai
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Publication number: 20110110828Abstract: A homogeneous immunoassay method and system for quantitative determination of total immunoglobulin E and specific antibody levels to a plurality of allergens, in which a relatively small sampling of blood is required. The method utilizes relatively small microparticles in aqueous suspension. The immunoassay procedure is an immunometric sandwich procedure preferably utilizing biotin-streptavidin signal amplification techniques and R-phycoerytherin fluorescent labels.Type: ApplicationFiled: January 13, 2011Publication date: May 12, 2011Inventors: CHRISTOPHER R. BROWN, James T. Murai
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Publication number: 20110104010Abstract: A homogeneous immunoassay method and system for quantitative determination of total immunoglobulin E and specific antibody levels to a plurality of allergens, in which a relatively small sampling of blood is required. The method utilizes relatively small microparticles in aqueous suspension. The immunoassay procedure is an immunometric sandwich procedure preferably utilizing biotin-streptavidin signal amplification techniques and R-phycoerytherin fluorescent labels.Type: ApplicationFiled: January 13, 2011Publication date: May 5, 2011Inventors: CHRISTOPHER R. BROWN, James T. Murai
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Patent number: 7892853Abstract: A homogeneous immunoassay method and system for quantitative determination of total immunoglobulin E and specific antibody levels to a plurality of allergens, in which a relatively small sampling of blood is required. The method utilizes relatively small microparticles in aqueous suspension. The immunoassay procedure is an immunometric sandwich procedure preferably utilizing biotin-streptavidin signal amplification techniques and R-phycoerytherin fluorescent labels.Type: GrantFiled: December 16, 2008Date of Patent: February 22, 2011Assignee: ImmuneTech, Inc.Inventors: Christopher R. Brown, James T. Murai
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Publication number: 20100184033Abstract: Aspects of the present invention relate to methods to differentiate pluripotent primordial stem cells, such as human embryonic stem (“hES”) cells, human embryonic germ (“hEG”) cells, human embryo-derived (“hED”) cells and human embryonal carcinoma (“hEC”) cells, to obtain subpopulations of cells from heterogeneous mixtures of cells, wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated 20 or more population doublings. This invention also provides novel compositions of such subpopulations of cells and methods to propagate and differentiate said cells.Type: ApplicationFiled: July 16, 2009Publication date: July 22, 2010Inventors: Michael D. West, Geoffrey Sargent, James T. Murai, Steven Kessler, Karen Chapman, David Larocca
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Publication number: 20090104625Abstract: A homogeneous immunoassay method and system for quantitative determination of total immunoglobulin E and specific antibody levels to a plurality of allergens, in which a relatively small sampling of blood is required. The method utilizes relatively small microparticles in aqueous suspension. The immunoassay procedure is an immunometric sandwich procedure preferably utilizing biotin-streptavidin signal amplification techniques and R-phycoerytherin fluorescent labels.Type: ApplicationFiled: December 16, 2008Publication date: April 23, 2009Inventors: Christopher R. Brown, James T. Murai
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Patent number: 7491553Abstract: A homogeneous immunoassay method and system for quantitative determination of total immunoglobulin E and specific antibody levels to a plurality of allergens, in which a relatively small sampling of blood is required. The method utilizes relatively small microparticles in aqueous suspension. The immunoassay procedure is an immunometric sandwich procedure preferably utilizing biotin-streptavidin signal amplification techniques and R-phycoerytherin fluorescent labels.Type: GrantFiled: April 10, 2007Date of Patent: February 17, 2009Assignee: ImmuneTech, Inc.Inventors: Christopher R. Brown, James T. Murai
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Patent number: 7413902Abstract: Methods and materials for culturing primate-derived primordial stem cells are described. In one embodiment, a cell culture medium for growing primate-derived primordial stem cells in a substantially undifferentiated state is provided which includes a low osmotic pressure, low endotoxin basic medium that is effective to support the growth of primate-derived primordial stem cells. The basic medium is combined with a nutrient serum effective to support the growth of primate-derived primordial stem cells and a substrate selected from feeder cells and an extracellular matrix component derived from feeder cells. The medium further includes non-essential amino acids, an anti-oxidant, and a first growth factor selected from nucleosides and a pyruvate salt.Type: GrantFiled: December 24, 2002Date of Patent: August 19, 2008Assignee: Geron CorporationInventors: Andrea G. Bodnar, Choy-Pik Chiu, Joseph D. Gold, Margaret Inokuma, James T. Murai, Michael D. West
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Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture
Patent number: 6800480Abstract: Methods and materials for culturing primate-derived primordial stem cells are described. In one embodiment, a cell culture medium for growing primate-derived primordial stem cells in a substantially undifferentiated state is provided which includes a low osmotic pressure, low endotoxin basic medium that is effective to support the growth of primate-derived primordial stem cells. The basic medium is combined with a nutrient serum effective to support the growth of primate-derived primordial stem cells and a substrate selected from the group consisting of feeder cells and an extracellular matrix component derived from feeder cells. The medium further includes non-essential amino acids, an anti-oxidant, and a first growth factor selected from the group consisting of nucleosides and a pyruvate salt.Type: GrantFiled: August 29, 2000Date of Patent: October 5, 2004Assignee: Geron CorporationInventors: Andrea G. Bodnar, Choy-Pik Chiu, Joseph D. Gold, Margaret Inokuma, James T. Murai, Michael D. West -
Publication number: 20030232397Abstract: A homogeneous immunoassay method and system for quantitative determination of total immunoglobulin E and specific antibody levels to a plurality of allergens, in which a relatively small sampling of blood is required. The method utilizes relatively small microparticles in aqueous suspension. The immunoassay procedure is an immunometric sandwich procedure preferably utilizing biotin-streptavidin signal amplification techniques and R-phycoerytherin fluorescent labels.Type: ApplicationFiled: March 12, 2003Publication date: December 18, 2003Applicant: Immunetech, Inc.Inventors: Christopher R. Brown, James T. Murai
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Publication number: 20030175956Abstract: Methods and materials for culturing primate-derived primordial stem cells are described. In one embodiment, a cell culture medium for growing primate-derived primordial stem cells in a substantially undifferentiated state is provided which includes a low osmotic pressure, low endotoxin basic medium that is effective to support the growth of primate-derived primordial stem cells. The basic medium is combined with a nutrient serum effective to support the growth of primate-derived primordial stem cells and a substrate selected from feeder cells and an extracellular matrix component derived from feeder cells. The medium further includes non-essential amino acids, an anti-oxidant, and a first growth factor selected from nucleosides and a pyruvate salt.Type: ApplicationFiled: December 24, 2002Publication date: September 18, 2003Inventors: Andrea G. Bodnar, Choy-Pik Chiu, Joseph D. Gold, Margaret Inokuma, James T. Murai, Michael D. West
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Publication number: 20030109067Abstract: A homogeneous immunoassay method and system for quantitative determination of total immunoglobulin E and specific antibody levels to a plurality of allergens, in which a relatively small sampling of blood is required. The method utilizes relatively small microparticles in suspension with 1-5 &mgr;L of undiluted sample. The immunoassay procedure is an immunometric sandwich procedure preferably utilizing biotin-streptavidin signal amplification techniques and R-phycoerytherin fluorescent labels.Type: ApplicationFiled: December 6, 2001Publication date: June 12, 2003Applicant: ImmuneTech, Inc.Inventors: Christopher R. Brown, James T. Murai