Abstract: Systems and methods for in vivo sensing are provided. An excitation signal is produced, having a first frequency component and a second frequency component. The first frequency component is swept through a plurality of excitation frequencies within a frequency range of interest.. A response signal is received from an in vivo sensor. The response signal includes a mix component having a frequency equal to one of a sum of a first excitation frequency associated with the first frequency component and a second excitation frequency associated with the second frequency component and a difference between the first and second excitation frequencies. The mix component is evaluated to determine a resonant frequency of the in vivo sensor.

Abstract: Methods and systems are provided for determining a characteristic of an in vivo sensor. A transmit field, operative to induce a response signal in an associated in vivo sensor, is generated at a transmitting component having an associated orientation. The response signal is received at a receiving component, having an associated orientation. The coupling between the transmitting component and the receiving component is measured. The associated orientation of at least one of the transmitting component and the receiving component is rotated as to reduce the measured coupling.