Abstract: This disclosure provides compositions and methods for the editing of a SERPINA1 gene with prime editing.

Abstract: The technology disclosed relates to tracking performance and initiatives of employees and providing real-time recognition for their successes and contributions through customizable recognition awards. In particular, it relates to automatically awarding recognition awards to an employee by evaluating the employee's current performance against progress features and exception features. The progress features indicate a progression of an individual across a work cycle and exception features indicate high performance of the individual during the work cycle. Thus the recognition awards are automatically awarded when the current performance of the employee evidences accomplishment of milestones or high performance.

Abstract: The present invention provides methods of preparing and identifying antibodies against a loop domain of a protein, such as an extracellular loop (ECL) domain of a transmembrane protein. Cyclic and end-to-end cyclized peptides corresponding to loop domains are employed in the present invention. Transmembrane proteins contemplated by the invention include the G-coupled protein receptor or a viral envelope protein.

Abstract: The present invention provides compositions of protein mimetics and methods of using same against HIV-1, SARS-coV and the like. In one aspect, the present invention relates to a protein mimetic for preventing HIV-1 entry to host cells of a living subject through membrane fusion, wherein HIV-1 contains at least one envelope glycoprotein gp41 that has a plurality of peptides in a pre-hairpin state. In one embodiment, the protein mimetic comprises at least two monomeric peptide strands and an interstrand linker coupling the monomeric peptide strands. The coupled monomeric peptide strands prevent the plurality of trimeric gp41 in a pre-hairpin state from transiting to a six-helix hairpin bundle, thereby inhibiting HIV-1 entry to the host cells through membrane fusion.