Abstract: Disclosed are methods of preparing hematopoietic stem cells and progenitor cells (HSPCs) for transplant into a subject and to methods of using the treated cells. More particularly, methods of the invention comprise treating HSPCs ex vivo with an effective amount of a GABBR1 agonist and administering the treated HSPCs to the subject.

Abstract: Disclosed are methods of preparing hematopoietic stem cells and progenitor cells (HSPCs) for transplant into a subject and to methods of using the treated cells. More particularly, methods of the invention comprise treating HSPCs ex vivo with an effective amount of a GABBR1 agonist and administering the treated HSPCs to the subject.

Abstract: A system for permission confirmation incorporates a terminal device for transmitting an authorization request on a network. The terminal device includes capability for encryption of the request and for decryption of a response. A request arbitrating server (RAS) is connected to the network for receiving the authorization request from the terminal device. The RAS incorporates capability for decryption of the request from the terminal display and determines an authorizing party responsive to the request. The RAS then has capability for encryption of a request to an authorizing party for transmission on the network, and, for decryption of a response and biometric data from the authorizing party. The RAS has capability to confirm biometric data received and encrypt a response to the terminal device. A user biometric device (UBD) is connected to the network having capability for receiving an authorization request from the RAS and decrypting the request.