Patents by Inventor James Tarrant

James Tarrant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted 1-Benzyl-4-Substituted Piperazine Analogues
    Publication number: 20070249616
    Abstract: Compounds of Formula I are provided, in which variables are as described herein: Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
    Type: Application
    Filed: June 15, 2007
    Publication date: October 25, 2007
    Applicant: NEUROGEN CORPORATION
    Inventors: Alan Hutchison, Bertrand Chenard, James Tarrant, Guiying Li, Manuka Ghosh, George Luke, John Peterson, Wallace Pringle, Mary-Margaret O'Donnell, Kyungae Lee, Linda Gustavson, Dario Doller
  • Substituted 1-benzyl-4-substituted piperazine analogues
    Publication number: 20060142301
    Abstract: Compounds of Formula I are provided, in which variables are as described herein: Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
    Type: Application
    Filed: April 6, 2005
    Publication date: June 29, 2006
    Inventors: Alan Hutchison, Bertrand Chenard, James Tarrant, Guiying Li, Manuka Ghosh, George Luke, John Peterson, Wallace Pringle, Mary-Margaret O'Donnell, Kyungae Lee, Linda Gustavson, Dario Doller
  • Novel tyrosine kinase inhibitors
    Publication number: 20060079518
    Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase enzymes thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases which can be treated by inhibiting tyrosine kinase enzymes.
    Type: Application
    Filed: November 30, 2005
    Publication date: April 13, 2006
    Inventors: Mark Wittman, Neelakantan Balasubramanian, Upender Velaparthi, Kurt Zimmermann, Mark Saulnier, Peiying Liu, Xiaopeng Sang, David Frennesson, Karen Stoffan, James Tarrant, Anne Marinier, Stephan Roy
  • Aryl-substituted piperazine derivatives
    Publication number: 20060009456
    Abstract: Aryl-substituted piperazine derivatives are provided. Such compounds may be used to modulate MCH receptor activity in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
    Type: Application
    Filed: June 16, 2005
    Publication date: January 12, 2006
    Inventors: Alan Hutchinson, Bertrand Chenard, Guiying Li, Manuka Ghosh, James Tarrant, Taeyoung Yoon, George Luke, Kyungae Lee, Mary-Margaret O'Donnell, Wallace Pringle, John Peterson, Kevin Hodgetts, Cheryl Steenstra, Dario Doller
  • Methods of treating cancer using C-4 carbonate taxanes
    Publication number: 20050250844
    Abstract: A process for the preparation of novel C-4 carbonate taxanes useful as antitumor agents.
    Type: Application
    Filed: March 22, 2005
    Publication date: November 10, 2005
    Inventors: John Kadow, Harold Mastalerz, Qiufen Xue, Steven Hansel, Mary Zoeckler, William Rose, James Tarrant
  • Substituted 1-heteroaryl-4-substituted piperazine and piperidine analogues
    Publication number: 20050239791
    Abstract: Compounds of Formula I are provided, in which variables are as described herein: Such compounds may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
    Type: Application
    Filed: April 6, 2005
    Publication date: October 27, 2005
    Inventors: Alan Hutchison, Bertrand Chenard, George Luke, Guiying Li, Manuka Ghosh, John Peterson, James Tarrant, Dario Doller
  • C-5 Modified indazolylpyrrolotriazines
    Publication number: 20050209235
    Abstract: The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
    Type: Application
    Filed: May 9, 2005
    Publication date: September 22, 2005
    Inventors: Harold Mastalerz, Guifen Zhang, James Tarrant, Gregory Vite