Abstract: The invention relates to LAG-3 binding agents, in particular variable heavy chain (VH) sdAbs and bispecific agents that target both LAG-3 and PD-1, and the use of such binding agents in the treatment, prevention and detection of disease.

Abstract: A semiconductor wafer cassette roller type transportation structure system includes a roller type transportation structure body, a rotating transportation structure body, and a lateral movement transportation structure body. The roller type transportation structure system includes connected left and right supporting frames. A plurality of large rollers are provided on an inner surface end of each of the right and left supporting frames. A plurality of small rollers are provided under the large rollers. A plurality of driving wheels are provided under the large rollers. The large and small rollers are driven by a driving belt. The driving wheels can linearly move a wafer cassette. In response to the roller type transportation structure body transporting the wafer cassette, the rotating transportation structure body rotates to change a movement direction of the wafer cassette, and the lateral movement transportation structure body transports the wafer cassette along a lateral movement direction.

Abstract: A semiconductor wafer cassette warehouse transportation structure system includes a wafer cassette lift transportation structure body, a wafer cassette frame structure body, an arm structure body, an arm gripping wafer cassette structure body, and a wafer cassette warehouse structure body. The suspension support rods are suspended on a ceiling. The wafer cassette lift transportation structure body lifts the wafer cassettes to the inlet and outlet. The arm structure body grips the wafer cassettes and puts same on the tracks so that the wafer cassettes can be transported to the wafer cassette warehouse structure body to be precisely accessed. The system saves space and facilitates the access of the wafer cassettes because the wafer cassettes are stored on the wafer cassette warehouse structure body suspended on the ceiling.

Abstract: A semiconductor wafer cassette roller type transportation structure system includes a roller type transportation structure body, a rotating transportation structure body, and a lateral movement transportation structure body. The roller type transportation structure system includes connected left and right supporting frames. A plurality of large rollers are provided on an inner surface end of each of the right and left supporting frames. A plurality of small rollers are provided under the large rollers. A plurality of driving wheels are provided under the large rollers. The large and small rollers are driven by a driving belt. The driving wheels can linearly move a wafer cassette. In response to the roller type transportation structure body vertically transporting the wafer cassette, the rotating transportation structure body rotates to change a movement direction of the wafer cassette, and the lateral movement transportation structure body transports the wafer cassette along a lateral movement direction.

Abstract: A semiconductor wafer cassette warehouse transportation structure system includes a wafer cassette lift transportation structure body, a wafer cassette frame structure body, an arm structure body, an arm gripping wafer cassette structure body, and a wafer cassette warehouse structure body. The suspension support rods are suspended on a ceiling. The wafer cassette lift transportation structure body lifts the wafer cassettes to the inlet and outlet. The arm structure body grips the wafer cassettes and puts same on the tracks so that the wafer cassettes can be transported to the wafer cassette warehouse structure body to be precisely accessed. The system saves space and facilitates the access of the wafer cassettes because the wafer cassettes are stored on the wafer cassette warehouse structure body suspended on the ceiling.

Abstract: According to one embodiment of the present invention, a method for identifying relevant database indexes is provided. According to one embodiment of the present invention, a method includes determining the importance of a particular database transaction and storing an index name related to the transaction along with an indicator of the importance. A database transaction is initiated and the importance indicator is received in an index advisor. The index advisor then makes an index recommendation based on the index importance.

Abstract: According to one embodiment of the present invention, a method for identifying relevant database indexes is provided. According to one embodiment of the present invention, a method includes determining the importance of a particular database transaction and storing an index name related to the transaction along with an indicator of the importance. A database transaction is initiated and the importance indicator is received in an index advisor. The index advisor then makes an index recommendation based on the index importance.

Abstract: Two transistors of a class D output stage are driven by complementary, variable duty cycle signals PWM+ and PWM?. When the pulse width of the PWM+ signal becomes too narrow for reliable operation of prior art over-current protection circuits sensing the drain to source voltage of FET1 driven by PWM+, a Narrow Pulse Detector generates a signal indicative of this narrow pulse condition. A Negative Current Sense circuit measures the drain to source voltage across FET2 during the much longer conduction time of FET2 driven by PWM?. Because of the energy stored in the series inductor coupled to the output of the class D stage, a negative current flows through this FET2 during its conduction time. The resulting drain to source voltage of FET2 is measured and compared to a threshold. If the voltage indicative of current is over the threshold, and the Narrow Pulse Detector output indicates a narrow pulse condition, then an inhibit signal is generated which reduces current.

Abstract: A method of searching a data page in a table space of a database for inserting a data record to a first table, wherein the table space comprises space map pages and sets of data pages, wherein each space map page comprises information about the available storage space of one set of data pages, wherein each space map page and the corresponding set of data pages is further assigned to a table range for each table to which at least one data page in the set of data pages belongs to, wherein the database further comprises a clustering index for the first table in the database management system, wherein the database management system comprises a space usage information database, and wherein the space usage information database holds space usage information for each table range.

Abstract: A circuit and method for determining overcurrent in a FET detects an output voltage of the FET in both a positive and negative polarity. The related positive or negative currents through the FET can be measured to determine whether an overcurrent condition exists. By measuring positive and negative currents in the FET, the overcurrent detector can obtain twice as much information as when measuring a positive current alone, and can respond more readily to overcurrent conditions. The overcurrent detector avoids the constraints typically observed in cycle-by-cycle PWM control with single polarity Vds sensing, while permitting a relaxation in the timing requirements for current sensing. A spike suppression circuit also contributes to longer sensing intervals.

Abstract: A system and method is provided for providing integrated over-current protection in a switching power supply. In one embodiment, a switching power supply could comprise a gate drive circuit operative to receive a pulse-width modulated (PWM) signal and to drive at least one power field effect transistor (FET) between alternating activated and deactivated states based on a pulse-width of the PWM signal. The switching power supply could also comprise a current sense circuit operative to measure a current associated with the at least one power FET during the activated state. The switching power supply could also comprise a first over-current protection circuit providing a first adjustment to the PWM signal in response to the current being substantially between a first threshold and a second threshold. The second threshold could be greater than the first threshold.

Abstract: Two transistors of a class D output stage are driven by complementary, variable duty cycle signals PWM+ and PWM?. When the pulse width of the PWM+ signal becomes too narrow for reliable operation of prior art over-current protection circuits sensing the drain to source voltage of FET1 driven by PWM+, a Narrow Pulse Detector generates a signal indicative of this narrow pulse condition. A Negative Current Sense circuit measures the drain to source voltage across FET2 during the much longer conduction time of FET2 driven by PWM?. Because of the energy stored in the series inductor coupled to the output of the class D stage, a negative current flows through this FET2 during its conduction time. The resulting drain to source voltage of FET2 is measured and compared to a threshold. If the voltage indicative of current is over the threshold, and the Narrow Pulse Detector output indicates a narrow pulse condition, then an inhibit signal is generated which reduces current.

Abstract: A method and system for controlling concurrency of access to data in a database system is provided. The method includes receiving a lock request for access to data in the database system, in which the lock request is a request for a page lock or a row lock for a corresponding row or page in the database system containing the data. The method further includes identifying a partition in the database system that contains the row or the page in the database system containing the data; associating the lock request with a partition lock on the partition that contains the row or the page in the database system containing the data; and accessing the data using the partition lock.

Abstract: A system and method is provided for detecting an over-current condition in a power field-effect transistor (FET). In one embodiment, an over-current detection circuit for detecting an over-current condition in a power FET comprises a current generator circuit operative to generate a reference current and a plurality of matched FETs operative to receive the reference current and provide a reference voltage, the matched FETs being matched to each other and to the power FET. The over-current detection circuit also comprises a comparator operative to measure a drain-to-source voltage of the power FET and to provide an output that indicates that the drain-to-source voltage of the power FET has exceeded the reference voltage.

Abstract: A partial index availability system places, in a restricted state, all pages in the index associated with a structure modification, when an error occurs in processing a log of the said structure modification. This maintains traversability of the rest of the index that is not in restricted state. The system locates and marks a left sentinel and a right sentinel associated with a non-leaf page that is in a restricted state preventing an undo of a transaction. The sentinels prevent a transaction from accessing an uncommitted change associated with the non-leaf page. After a recovery procedure is run the entire index is made available. During the period between the placement of the index pages in LPL or rebuild pending to the time of final removal of these pages from their restrictive states as a result of a recovery procedure being run, the users are given access to the non-restricted portion of the index.

Abstract: According to the method for establishing a log point an information technology infrastructure is provided. Transactions are performed by at least two database units of the information technology infrastructure. Then, “suspending prepare to commit”-requests are sent from said coordinating device to said database units. The log writes of all database units are suspended and recorded, whereas these log points form a global log point. Finally the log writes of all database units and all the suspended transactions are resumed.

Abstract: A computer implemented method, apparatus, and computer usable program code for managing a table space for a database. The table space is searched to find available free space in a set of partitions in the table space in response to receiving a request to insert a record into a database table in the database. A new partition is created for the table space based on a size for the new partition in response to determining free space is unavailable for the record in the set of partitions. The record is inserted into the new partition.

Abstract: A circuit and method for determining overcurrent in a FET detects an output voltage of the FET in both a positive and negative polarity. The related positive or negative currents through the FET can be measured to determine whether an overcurrent condition exists. By measuring positive and negative currents in the FET, the overcurrent detector can obtain twice as much information as when measuring a positive current alone, and can respond more readily to overcurrent conditions. The overcurrent detector avoids the constraints typically observed in cycle-by-cycle PWM control with single polarity Vds sensing, while permitting a relaxation in the timing requirements for current sensing. A spike suppression circuit also contributes to longer sensing intervals.

Abstract: A method of searching a data page in a table space of a database for inserting a data record to a first table, wherein the table space comprises space map pages and sets of data pages, wherein each space map page comprises information about the available storage space of one set of data pages, wherein each space map page and the corresponding set of data pages is further assigned to a table range for each table to which at least one data page in the set of data pages belongs to, wherein the database further comprises a clustering index for the first table in the database management system, wherein the database management system comprises a space usage information database, and wherein the space usage information database holds space usage information for each table range.

Abstract: Provided are a techniques for reorganizing data. Data is retrieved from an original data set and inserted into a shadow data set. A log record is read from an update log, wherein the log record includes a unique key identifying a data object and an indication of an activity associated with that data object. The activity associated with the data object is performed by determining whether the unique key is found in a shadow index for the shadow data set.