Patents by Inventor James Thoden

James Thoden has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11697635
    Abstract: Disclosed are methods of purifying the compound (22E)-(24R)-2-methylene-22-dehydro-1?,24,25-trihydroxy-19-nor-vitamin D3 to obtain the compound in crystalline form. The methods typically include the steps of dissolving (22E)-(24R)-2-methylene-22-dehydro-1?,24,25-trihydroxy-19-nor-vitamin D3 in a solvent comprising ethyl acetate and hexane to form a solution, allowing crystals of (22E)-(24R)-2-methylene-22-dehydro-1?,24,25-trihydroxy-19-nor-vitamin D3 to form and precipitate from the solution, and recovering the crystals of (22E)-(24R)-2-methylene-22-dehydro-1?,24,25-trihydroxy-19-nor-vitamin D3 from the solution.
    Type: Grant
    Filed: October 16, 2018
    Date of Patent: July 11, 2023
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Hector F. Deluca, Margaret Clagett-Dame, Lori Plum, Agnieszka Flores, James Thoden, Hazel Holden
  • Publication number: 20200262773
    Abstract: Disclosed are methods of purifying the compound (22E)-(24R)-2-methylene-22-dehydro-1?,24,25-trihydroxy-19-nor-vitamin D3 to obtain the compound in crystalline form. The methods typically include the steps of dissolving (22E)-(24R)-2-methylene-22-dehydro-1?,24,25-trihydroxy-19-nor-vitamin D3 in a solvent comprising ethyl acetate and hexane to form a solution, allowing crystals of (22E)-(24R)-2-methylene-22-dehydro-1?,24,25-trihydroxy-19-nor-vitamin D3 to form and precipitate from the solution, and recovering the crystals of (22E)-(24R)-2-methylene-22-dehydro-1?,24,25-trihydroxy-19-nor-vitamin D3 from the solution.
    Type: Application
    Filed: October 16, 2018
    Publication date: August 20, 2020
    Inventors: Hector F. DELUCA, Margaret CLAGETT-DAME, Lori PLUM, Agnieszka FLORES, James THODEN, Hazel HOLDEN
  • Patent number: 10494337
    Abstract: Disclosed are 1?,25-dihydroxy-24,24-difluoro-2-methylene-19-nor-vitamin D analogs and their pharmaceutical uses. These new vitamin D analogs are 19-nor-vitamin D analogs having two fluorine atom substitutions at the 24 position (C-24) in the side chain and optionally having a 2-methylene substituent.
    Type: Grant
    Filed: May 26, 2016
    Date of Patent: December 3, 2019
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Hector F. DeLuca, Agnieszka Flores, Lori A. Plum, Hazel Holden, James Thoden
  • Publication number: 20160347710
    Abstract: Disclosed are 1?,25-dihydroxy-24,24-difluoro-2-methylene-19-nor-vitamin D analogs and their pharmaceutical uses. These new vitamin D analogs are 19-nor-vitamin D analogs having two fluorine atom substitutions at the 24 position (C-24) in the side chain and optionally having a 2-methylene substituent.
    Type: Application
    Filed: May 26, 2016
    Publication date: December 1, 2016
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Agnieszka Flores, Lori A. Plum, Hazel Holden, James Thoden
  • Publication number: 20050112723
    Abstract: Genetically modified cell lines that express a UDP-galactose 4-epimerase (GALE) capable of interconverting UDP-galactose (UDP-gal) and UDP-glucose (UDP-glc), but essentially incapable of interconverting UDP-N-acetylgalactosamine (UDP-galNAc) and UDP-N-acetylglucosamine (UDP-glcNAc).
    Type: Application
    Filed: February 18, 2004
    Publication date: May 26, 2005
    Inventors: Judith Fridovich-Keil, Monty Krieger, Hazel Holden, James Thoden, Jenny Schulz