Abstract: Techniques for generating and maintaining a student academic ledger are disclosed. In some embodiments, student data is received from a first set of one or more members of a blockchain network. In response, one or more distributed ledgers are updated in the blockchain network. The distributed ledgers are accessible to a student member of the blockchain network using a private key. The blockchain network receives requests from the student member to initiate a transaction with a second set of one or more members that requires access to at least a subset of the student data. Responsive to the request, the second set of one or more members are granted access to at least the subset of the student data from at least one distributed ledger.

Abstract: The present invention relates to compounds of formula (I) that function as inhibitors of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity: X—Y—Z?? (I) wherein X, Y and Z are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, and autoimmune diseases, as well as other diseases or conditions in which METTL3 activity is implicated.

Abstract: A medical device hub power management system, method, and apparatus are disclosed. An example hub connectivity station includes a connectivity stage configured to provide a data connection with an external network. The hub connectivity station also includes at least one docking apparatus configured to connect to at least one medical device. The docking apparatuses are connected to the connectivity station in a stacked arrangement. The docking apparatuses and connectivity stage include power and data connectors to enable data and power to be provided through the hub connectivity station. To prevent electrical shock, a top power connector of each docking apparatus is disconnected from power when that docking apparatus is not connected to another docking apparatus or the connectivity stage. Power is provided to the top power connector after detecting another docking apparatus or the connectivity stage is connected to the top of the docking apparatus.

Abstract: A glass-based assembly includes a glass or glass-ceramic substrate comprising a surface. The surface has flaws, such as a population of small cracks extending into the surface, whereby the substrate is weakened relative to ideal strength thereof. The assembly further includes a coating coupled to the substrate and overlaying at least some of the flaws. Ultimate strength of the substrate with the coating coupled thereto is greater than that of the substrate alone, without the coating.

Abstract: There is provided a method for manufacturing graphene, the method comprising: forming graphene on a non-metallic surface of a substrate by CVD in a CVD reaction chamber, wherein the step of forming graphene comprises introducing a precursor in a gas phase and/or suspended in a gas into the CVD reaction chamber; wherein the precursor consists of one or more compounds selected from a C4-C10 organic compound; wherein the organic compound is branched such that the organic compound has at least three methyl groups; and wherein the organic compound consists of carbon and hydrogen and, optionally, oxygen, fluorine, chlorine and/or bromine.

Abstract: The present disclosure relates to medicament injection devices. An injection device includes: a movable dosage programming component comprising a rotary encoder system having a predefined angular periodicity, a sensor arrangement including a first optical sensor configured to detect movement of the movable dosage programming component relative to the sensor arrangement during dosing of a medicament, wherein the first optical sensor is configured to operate in a strobe-sampling mode at a first frequency, a second optical sensor configured to detect movement of the rotary encoder system relative to the second optical sensor wherein the second optical sensor is configured to operate in a strobe-sampling mode at a second frequency lower than the first frequency, and a processor arrangement configured to, based on the detected movement, determine a medicament dosage administered by the injection device.

Abstract: A method includes transmitting a first wireless communication from a user device via an authorized first cellular network. The first wireless communication includes a current geographic location of the user device. The user device maintains a forbidden list identifying unauthorized cellular networks. Based on determining that the user device is approaching a geofence between a first network coverage area of the first cellular network and a second network coverage area of a second cellular network that is identified on the forbidden list, the method includes removing the second cellular network from the forbidden list. With the second cellular network removed from the forbidden list and based on the user device entering the second network coverage area, the method includes transmitting a second wireless communication from the user device via the second cellular network that includes an updated geographic location of the user device.

Abstract: A LiDAR apparatus, including: a laser to generate an optical signal; modulation components configured to receive the optical signal as an input and to output at least two corresponding modulated optical signals at respective output ports, wherein each modulated optical signal is modulated by a corresponding pseudo-random bit sequence, and: (i) the optical signals have respective different delays such that the modulations do not overlap in time; or (ii) the pseudo-random bit sequences have low cross-correlation; for each of the at least two modulated optical signals, a corresponding optical transmitter configured to transmit the corresponding modulated optical signal towards a corresponding surface spaced from the LiDAR apparatus by a corresponding distance, and a corresponding optical receiver configured to receive a portion of the transmitted optical signal scattered and/or reflected by the surface, the received portion of the optical signal having a phase shift and/or Doppler shifted angular frequency due t

Abstract: Methods and systems for providing a flow of fluid to an endoscope. An illustrative container and tube set arranged and configured to couple to an endoscope may comprise, a first container configured to contain a fluid, a first water supply tube including a first lumen extending therethrough and in selective fluid communication with the first container, a first gas supply tube including a second lumen extending therethrough and in fluid communication with the first container, a second container configured to contain a fluid, a second water supply tube including a third lumen extending therethrough and in fluid communication with the second container, and a fluid flow control mechanism positioned in-line with the second water supply tube, the fluid flow control mechanism configured to selectively fluidly couple the second container with the first container.

Abstract: Technology for generating and displaying a graphical user interface for operating an unmanned aerial vehicle (UAV) is disclosed herein that generates and updates a representation of a spline flight path. In various implementations, a graphical user interface detects user interactions with a remote control device directing the flight control subsystem of the UAV to record keyframes and to compute a spline based on the keyframes during flight. The graphical user interface displays a real-time perspective of the UAV with a representation of the spline and the keyframes overlaying the view. The graphical user interface continually updates the representation as the UAV flies and when the spline is updated as the keyframes are updated.

Abstract: A quick connect mounting assembly for a ceiling fan. The quick connect mounting assembly includes two releasably attachable mounts that are easily interconnected to mechanically couple elements of a ceiling fan. The quick connect mounting assembly can be used to mount at least two elements of the ceiling fan, such as any two of a mounting bracket, a canopy, a switch housing, a motor housing, a motor with a motor shaft, or a light fixture.

Abstract: This invention relates to, among other embodiments, methods and apparatus/systems for controlling gases delivery to a patient, such as via a patient interface. Such methods comprising receiving an input relating to either a patient's breathing phase and/or another patient parameter, controlling a flow of gases to be delivered to the patient and the inclusion in said flow of gases of a supplementary gas, wherein the amount of supplementary gas provided to the patient is substantially synchronized with respect to the patient's breathing phase and/or another patient parameter.

Abstract: The present disclosure provides GLP-1R agonists, and compositions, methods, and kits thereof. Such compounds are generally useful for treating a GLP-1R mediated disease or condition.

Abstract: Described are coated porous polymeric filter membranes that include a filter membrane substrate and an ionic polymer coating applied to the surface of the substrate; methods of making the coated porous polymeric filter membranes and filters that include such a coated membrane; and method of using the coated membranes to remove metal ions from purified water.

Abstract: A bladeless fan including a housing, an impeller within the housing, a motor within the housing for rotatably driving the impeller, an outlet device having an at least partially circular outlet, and a diffuser configured to receive air from the impeller and direct the air into the outlet device, the diffuser at least partially changing a direction of the air being directed into the outlet device.

Abstract: An embodiment of an exhaust collection system for collecting exhaust from a marine vessel includes an exhaust cleaning assembly including a tank. In addition, the exhaust collection system includes a vent hood in fluid communication with the tank of the exhaust cleaning assembly. The vent hood includes a frame including one or more extendable frame members, and an outer covering that covers the frame to define an enclosure with an opening configured to receive an exhaust stack of the marine vessel therethrough, the one or more extendable frame members to extend and retract to adjust a size of the opening.

Abstract: A mobile device securely communicates with an electronic device within an automobile. The mobile device transmits encrypted spatial state information and the electronic device provides commands to the automobile in response. Spatial state information may include location, motion, or the like. Commands to the automobile may include door unlock commands, remote start commands, horn honk commands, or the like.

Abstract: An embodiment in accordance with the present invention provides a handheld cryoprobe for use in percutaneous cryotherapy of tumorous masses. It includes a probe attached to a CO2 gas dispensing backend. The probe has specifically optimized parameters designed for use with CO2 gas and is made out of a partially hollowed and threaded aluminum rod providing maximum heat exchange. The system backend regulates flow of compressed CO2 gas while throttling and cooling the gas coolant to the cytotoxically low temperatures necessary for targeted tumor cell death. Additionally, the incoming initial stream of CO2 gas is throttled by the Joule-Thomson nozzle on the backend. The low temperature exhaust gas is then used to pre-cool all subsequent incoming gas, resulting in an even lower temperature at the probe tip, which provides a positive feedback loop, continually decreasing the gas's temperature. The temperature drop is caused by the Joule-Thomson effect.

Abstract: The invention provides a compound of formula (1). or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: Pitch products produced by systems and processes utilizing coal tar or decant oil for coal or petroleum based pitch are disclosed. Total pitch production yields are increased by heat treating distillate fractions from the pitch production process. A heat treatment system, process and products produced thereby are disclosed. The heaviest distillates having the highest molecular weights are subjected to heat treatment, though other embodiments contemplate heat treating a variety of combined distillate fractions. The heat treatment systems require heat soaking the distillate(s) at elevated temperatures of 459-535° C. at a near-constant temperature with near-uniform flow. A fraction of the heat-treated distillate may be reintroduced to the pitch production system as part of a continuous process.