Abstract: A method for making a cold plate includes the steps of positioning a finstock structure in a cavity of a substrate; and applying a cover to the finstock structure and substrate, wherein the applying step comprises ultrasonically additive manufacturing the cover to the substrate and the finstock structure, whereby the cover joins with the substrate and the finstock structure. The resulting cold plate assembly includes a substrate having a cavity, a finstock structure within the cavity, and a cover closing the finstock structure within the cavity, the cover being integrally joined to the substrate and to the finstock structure.

Abstract: A method of branch prediction in a processor includes: obtaining, by the processor, a branch instruction for which a direction of a branch is to be predicted; generating, by the processor, an index based on an instruction address, a global path vector (GPV), and a counter; selecting, by the processor, an entry from a data structure using the index; and predicting, by the processor, the direction of the branch using information included in the selected entry. The method may include modifying a tag in the selected entry based at least in part on another GPV.

Abstract: Some embodiments of the disclosure include disclosed compounds (e.g., compounds of Formula (I)) and compositions (e.g., pharmaceutical compositions) which inhibit IRAK and/or FLT3 and which can be used for treating, for example, certain diseases. Some embodiments include methods of using the disclosed compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases such as hematopoietic cancers, myelodysplastic syndromes (MDS), acute myeloid leukemia (AML), etc.). Additional embodiments provide disease treatment using combinations of the disclosed IRAK and/or FLT3 inhibiting compounds with other therapies, such as cancer therapies.

Abstract: Provided herein are compounds of the formula (I): wherein the variables are as defined herein. Pharmaceutical compositions of the compounds are also provided. In some aspects, these compounds may be used for the treatment of diseases or disorders, such as a bacterial infection.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: Metal-based ceramic composite coatings and related devices, assemblies, and methods include monocrystalline superhard particles dispersed in a metal matrix disposed on at least one wear surface of a component of an oil and gas well assembly, system, or device.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.

Abstract: The present disclosure relates to aqueous compositions containing water and the ammonium salt of a polyamide-amic acid. Processes for producing such aqueous compositions and uses thereof are described.

Abstract: A cover article for a sensor is described herein that includes: a substrate comprising a thickness from 50 ?m to 5000 ?m, an outer primary surface, and an inner primary surface; and an outer layered film disposed on the outer primary surface. The substrate is a chemically-strengthened glass or glass-ceramic substrate. The cover article exhibits a first-surface average reflectance of less than 10% for wavelengths from 1000 nm to 1700 nm for at least one angle of incidence from 8° to 60°.

Abstract: System and methods may facilitate user guidance to risk relationship documents for an enterprise. A risk relationship document data store may contain a set of electronic data records, each electronic data record being associated with a risk relationship document and including a document identifier and a set of document metadata values. A document navigation computer may receive information from a user associated with the enterprise, and, based on the information received from the user and document metadata values, dynamically create a sub-set of the documents in the risk relationship data document data store. An interactive user interface display computer may provide indications associated with the documents in the dynamically created sub-set to the user via an interactive user interface and receive a selected document of the dynamically created sub-set. The user interface display computer may then, responsive to the selection, deliver the selected document to a remote user device.

Abstract: The system includes a robot interface disposed on a robot arm, and an end effector configured to selectively couple to the robot arm via the robot interface. The end effector includes an upper jaw, a lower jaw, and a pair of arms configured to carry a substrate. The upper jaw and the lower jaw are spaced apart in a first direction and biased together, and the pair of arms are spaced apart in a second direction orthogonal to the first direction. When the end effector is coupled to the robot arm, the robot interface is disposed between the upper jaw and the lower jaw. To exchange the end effector, the upper jaw and the lower jaw can be separated to release the robot interface.

Abstract: Low waste methods for three-dimensional printing techniques are provided. A method includes performing a preceding additive infusion process including: solubilizing an additive into a medium in a supercritical fluid state; contacting a preceding material with the medium to infuse a portion of the additive into the preceding material to form a preceding additive-infused material; and separating remaining additive from the medium. Further, the method includes performing at least one succeeding additive infusion process including: solubilizing the remaining additive and, optionally, additional additive, into the medium in a supercritical fluid state; and contacting a succeeding material with the medium to infuse at least a portion of the remaining and additional additive into the succeeding material to form a succeeding additive-infused material, wherein the medium from the preceding additive infusion process is reused in the at least one succeeding additive infusion process.

Abstract: Methods for manufacturing three-dimensional objects using an additive manufacturing technique, methods for forming dye-infused feed material for an additive manufacturing technique, and vehicles including additive manufactured components are provided. An exemplary method for manufacturing a three-dimensional object using an additive manufacturing technique includes solubilizing a dye into a medium in the form of a supercritical fluid and contacting a feed material with the medium to infuse the dye into the feed material to form dye-infused feed material. The method further includes locally melting the dye-infused feed material in selected regions of a layer corresponding to a cross-section of a three-dimensional object being formed and solidifying the dye-infused feed material into a solid layer of dye-infused material. Further, the method includes repeating the local melting and solidifying steps to form the three-dimensional object made up of a plurality of solid layers of dye-infused material.

Abstract: A hardware assembly providing a motion-activated vent stop for a vent window assembly. The hardware assembly can detect excessive forces acting on the vent and quickly arrest any unintended or induced movement of the vent while enabling the regular function of the vent window under normal operating conditions. When an opening force acting on the vent exceeds a predetermined value, the resulting torque causes a shoe to pivot and engage a stepped profile of a guide slot of a track along which the shoe moves. Once engaged, the shoe cannot move along the track and continued movement of the vent is halted. The shoe includes a biasing member that engages the guide slot and produces a counter-torque that tends to bias the shoe generally vertically in the guide slot and enable the shoe to travel freely under normal operating conditions.

Abstract: Methods for forming a function-infused feed material for a three-dimensional printing technique, methods for manufacturing an additive-infused three-dimensional printed object, and vehicles including additive manufactured components are provided. An exemplary method for forming a function-infused feed material for a three-dimensional printing technique includes solubilizing a functional additive into a medium. Further, the method includes contacting a three-dimensional printing feed material with the medium to infuse the functional additive into the three-dimensional printing feed material to form the function-infused feed material.

Abstract: Methods and systems for control of solid phase peptide synthesis are generally described. Control of solid phase peptide synthesis involves the use of feedback from one or more reactions and/or processes (e.g., reagent removal) taking place in the solid phase peptide synthesis system. In some embodiments, a detector may detect one or more fluids flowing across a detection zone of a solid phase peptide synthesis system and one or more signals may be generated corresponding to the fluid(s). For instance, an electromagnetic radiation detector positioned downstream of a reactor may detect a fluid exiting the reactor after a deprotection reactor and produce a signal(s). In some embodiments, based at least in part on information derived from the signal(s), a parameter of the system may be modulated prior to and/or during one or more subsequent reactions and/or processes taking place in the solid phase peptide synthesis system.

Abstract: A wheel locking device comprising a number of interlocking components that are adapted to receive a wheel (or a wheeled apparatus), and said components can be adjusted to accommodate a variety of wheels of different diameters. The wheel locking device further comprises a rotatable and adjustable bar that is utilized to secure the wheel in place. In further embodiments, the device comprises a lock receiving bore which is adapted to receive a lock.

Abstract: Embodiments disclosed herein generally relate to connected machine learning models with joint training for lesion detection. Particularly, aspects of the present disclosure are directed to accessing a three-dimensional magnetic resonance imaging (MRI) image, wherein the three-dimensional MRI image depicts a region of a brain of a subject, wherein the region of the brain includes at least a first type of lesions and a second type of lesions; inputting the three-dimensional MRI image into a machine-learning model comprising a first convolutional neural network and a second convolutional neural network; generating a first segmentation mask for the first type of lesions using the first convolutional neural network that takes as input the three-dimensional MRI image; generating a second segmentation mask for the second type of lesions using the second convolutional neural network that takes as input the three-dimensional MRI image; and outputting the first segmentation mask and the second segmentation mask.

Abstract: Embodiments of the disclosure relate to the aligning of a melting beam source in an additive manufacturing (AM) system. Methods of the disclosure may include forming a first test article and a second test article of different shapes on a build plate. The method further includes measuring a vertical scale, vertical alignment, horizontal scale, and an alignment of the melting beam source using the first and second test articles. The method includes determining whether one of the vertical scale, the vertical alignment, the horizontal scale, or the horizontal alignment of the melting beam source is not within a corresponding tolerance of a target specification. If at least one of the vertical scale, the vertical alignment, the horizontal scale, or the horizontal alignment is within the corresponding tolerance, the method includes adjusting the melting beam source of the AM system to align the melting beam source to yield the target specification.

Abstract: Disclosed herein are glass pharmaceutical vials having sidewalls of reduced thickness. In embodiments, the glass pharmaceutical vial may include a glass body comprising a sidewall enclosing an interior volume. An outer diameter D of the glass body is equal to a diameter d1 of a glass vial of size X as defined by ISO 8362-1, wherein X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1. However, the sidewall of the glass pharmaceutical vial comprises an average wall thickness Ti that is less than or equal to 0.85*s1, wherein s1 is a wall thickness of the glass vial of size X as defined by ISO 8362-1 and X is one of 2R, 3R, 4R, 6R, 8R, 10R, 15R, 20R, 25R, 30R, 50R, and 100R as defined by ISO 8362-1.