Patents by Inventor James Thomas Koerber

James Thomas Koerber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-KLK7 ANTIBODIES, ANTI-KLK5 ANTIBODIES, MULTISPECIFIC ANTI-KLK5/KLK7 ANTIBODIES, AND METHODS OF USE
    Publication number: 20240150491
    Abstract: The invention provides anti-KLK7 antibodies, anti-KLK5 antibodies, anti-KLK5/KLK7 multispecific antibodies, and methods of using the same.
    Type: Application
    Filed: December 19, 2023
    Publication date: May 9, 2024
    Applicant: Genentech, Inc.
    Inventors: James Thomas KOERBER, Wyne Pun LEE, Tangsheng YI, Juan ZHANG, Cary Dean AUSTIN, Cecilia P.C. CHIU, Joseph Edward CHAVARRIA-SMITH, Jawahar SUDHAMSU
  • ANTI-UBIQUITINATION ANTIBODIES AND METHODS OF USE
    Publication number: 20240109958
    Abstract: Provided herein are antibodies that bind to a peptide of an N-terminally ubiquitinated polypeptide and methods of screening for such antibodies. Also provided herein are detection and enrichment methods using such antibodies for detecting or enriching a peptide of an N-terminally ubiquitinated polypeptide.
    Type: Application
    Filed: December 12, 2023
    Publication date: April 4, 2024
    Applicant: Genentech, Inc.
    Inventors: Donald Scott KIRKPATRICK, James Thomas KOERBER, Christopher Williamson DAVIES
  • ANTI-KLK7 ANTIBODIES, ANTI-KLK5 ANTIBODIES, MULTISPECIFIC ANTI-KLK5/KLK7 ANTIBODIES, AND METHODS OF USE
    Publication number: 20240084042
    Abstract: The invention provides anti-KLK7 antibodies, anti-KLK5 antibodies, anti-KLK5/KLK7 multispecific antibodies, and methods of using the same.
    Type: Application
    Filed: September 11, 2023
    Publication date: March 14, 2024
    Applicant: Genentech, Inc.
    Inventors: James Thomas Koerber, Wyne Pun Lee, Tangsheng Yi, Juan Zhang, Cary Dean Austin, Cecilia Pui Chi Chiu, Joseph Edward Chavarria-Smith, Jawahar Sudhamsu
  • CD8 BINDING AGENTS AND USES THEREOF
    Publication number: 20230192853
    Abstract: Provided are CD8 binding agents comprising a VHH domain that specifically binds human CD8. Also provided are nucleic acids encoding such CD8 binding agents, vectors comprising such nucleic acids, host cells comprising same, and methods of making such CD8 binding agents. Also provided are CD8 binding agents having the VHH domain conjugated to a detectable label. Provided are methods of using such CD8 binding agents to detect CD8+ T cells, monitor disease progress, and monitor treatment progress in a subject having cancer, autoimmune disease or condition, transplant rejection or graft-versus-host disease.
    Type: Application
    Filed: September 3, 2020
    Publication date: June 22, 2023
    Inventors: James Thomas KOERBER, Alejandra Beatrice Urpi URRUTIA, Simon-Peter WILLIAMS, Christopher Williamson DAVIES, Shravan Kumar SRIRAMAN, Herman Singh GILL, James Richard KIEFER, Jr.
  • METHODS FOR MAKING EXTRACELLULAR VESICLES AND USES THEREOF
    Publication number: 20230090177
    Abstract: The present disclosure relates to improved methods and compositions for making extracellular vesicles (EVs). The present disclosure also relates to novel EV-based ELISA assays and kits for performing such assays, as well as methods of producing antibodies to particular antigens using EVs comprising membrane-bound antigen.
    Type: Application
    Filed: November 28, 2022
    Publication date: March 23, 2023
    Applicant: GENENTECH, INC.
    Inventors: James Thomas Koerber, Yonglian Sun
  • KRAS SPECIFIC ANTIBODIES AND USES THEREOF
    Publication number: 20220112308
    Abstract: Provided herein are anti-KRas antibodies that bind to mutant KRas-GDP and alkylated mutant KRas-GDP and methods of using the same. Also provide herein are method of screening for KRas inhibitors and methods of measuring binding of KRas to the antibodies described herein.
    Type: Application
    Filed: April 28, 2021
    Publication date: April 14, 2022
    Applicant: Genentech, Inc.
    Inventors: MELINDA M. MULVIHILL, JOHN GERARD QUINN, MICAH STEFFEK, WEIRU WANG, JOHN BRUNING, CHRISTOPHER WILLIAMSON DAVIES, MARIE EVANGELISTA, JAMES THOMAS KOERBER
  • METHODS FOR DETECTING AND QUANTIFYING MEMBRANE-ASSOCIATED PROTEINS
    Publication number: 20220099677
    Abstract: The present disclosure provides assays for the detection and/or quantification of membrane-associated proteins, e.g., circulating CD20 (cCD20), incorporating an extracellular vesicle-based calibrator comprising the membrane-associated tumor antigen as well as the use of such assays in the detection and treatment of hyperproliferative disorders.
    Type: Application
    Filed: September 8, 2021
    Publication date: March 31, 2022
    Applicant: GENENTECH, INC.
    Inventors: Vinita GUPTA, Ann Therese BRADY, James Thomas KOERBER, Xiangdan WANG, Minh Michael Nhu PHAN, Yonglian SUN
  • ANTI-KLK7 ANTIBODIES, ANTI-KLK5 ANTIBODIES, MULTISPECIFIC ANTI-KLK5/KLK7 ANTIBODIES, AND METHODS OF USE
    Publication number: 20210130492
    Abstract: The invention provides anti-KLK7 antibodies, anti-KLK5 antibodies, anti-KLK5/KLK7 multispecific antibodies, and methods of using the same.
    Type: Application
    Filed: September 17, 2020
    Publication date: May 6, 2021
    Applicant: Genentech, Inc.
    Inventors: James Thomas Koerber, Wyne Pun Lee, Tangsheng Yi, Juan Zhang, Cary Dean Austin, Cecilia P.C. Chiu, Joseph Chavarria-Smith, Jawahar Sudhamsu