Patents by Inventor JAMES TIEN

JAMES TIEN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF SYNTHESIZING 4-VALYLOXYBUTYRIC ACID
    Publication number: 20260209170
    Abstract: The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.
    Type: Application
    Filed: March 18, 2026
    Publication date: July 23, 2026
    Inventors: Jia-Ning XIANG, Hao-Wei SHIH, Xiaoming WU, Xuan ZHANG, James TIEN
  • CRYSTALLINE 4-((L-VALYL)OXY)BUTANOIC ACID SALTS
    Publication number: 20260116843
    Abstract: Crystalline 4-((L-valyl)oxy)butanoic acid salts, methods of preparing the crystalline 4-((L-valyl)oxy)butanoic acid salts, pharmaceutical compositions containing the crystalline 4-((L-valyl)oxy)butanoic acid salts, and methods of treatment using the crystalline 4-((L-valyl)oxy)butanoic acid salts are disclosed.
    Type: Application
    Filed: October 21, 2025
    Publication date: April 30, 2026
    Inventors: James TIEN, Xuan ZHANG, Hao-Wei SHIH, Jia-Ning XIANG
  • Methods of synthesizing 4-valyloxybutyric acid
    Patent number: 12612357
    Abstract: The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.
    Type: Grant
    Filed: May 29, 2024
    Date of Patent: April 28, 2026
    Assignee: XWPharma Ltd.
    Inventors: Jia-Ning Xiang, Hao-Wei Shih, Xiaoming Wu, Xuan Zhang, James Tien
  • MODIFIED RELEASE COMPOSITIONS OF A GAMMA-HYDROXYBUTYRIC ACID DERIVATIVE
    Publication number: 20250352481
    Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing 4-((L-valyl)oxy)butanoic acid are disclosed. The functional coatings provide for immediate release or modified release of 4-((L-valyl)oxy)butanoic acid. The pharmaceutical granulations can be used in oral pharmaceutical compositions.
    Type: Application
    Filed: August 1, 2025
    Publication date: November 20, 2025
    Inventors: Sami KARABORNI, Daniel M. CANAFAX, Jia-Ning XIANG, William W. XIANG, James TIEN, Stefanie THIEL, Norbert POLLINGER, Annette GRAVE
  • Modified release compositions of a gamma-hydroxybutyric acid derivative
    Patent number: 12396956
    Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing 4-((L-valyl)oxy)butanoic acid are disclosed. The functional coatings provide for immediate release or modified release of 4-((L-valyl)oxy)butanoic acid. The pharmaceutical granulations can be used in oral pharmaceutical compositions.
    Type: Grant
    Filed: January 24, 2024
    Date of Patent: August 26, 2025
    Assignee: XWPHARMA LTD.
    Inventors: Sami Karaborni, Daniel M. Canafax, Jia-Ning Xiang, William W. Xiang, James Tien, Stefanie Thiel, Norbert Pollinger, Annette Grave
  • CONTROLLED RELEASE GRANULATIONS OF WATER-SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS
    Publication number: 20250262157
    Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing a water-soluble active pharmaceutical ingredient are disclosed. The functional coating provides for immediate release or controlled release of the active pharmaceutical ingredient. The pharmaceutical granulations can be used in oral pharmaceutical compositions.
    Type: Application
    Filed: May 7, 2025
    Publication date: August 21, 2025
    Inventors: SAMI KARABORNI, DANIEL M. CANAFAX, JIA-NING XIANG, WILLIAM W. XIANG, JAMES TIEN, NICOLAS D. KIRKLAND
  • Controlled release granulations of water-soluble active pharmaceutical ingredients
    Patent number: 12337066
    Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing a water-soluble active pharmaceutical ingredient are disclosed. The functional coating provides for immediate release or controlled release of the active pharmaceutical ingredient. The pharmaceutical granulations can be used in oral pharmaceutical compositions.
    Type: Grant
    Filed: March 4, 2022
    Date of Patent: June 24, 2025
    Assignee: XWPHARMA LTD.
    Inventors: Sami Karaborni, Daniel M. Canafax, Jia-Ning Xiang, William W. Xiang, James Tien, Nicolas D. Kirkland
  • METHODS OF SYNTHESIZING 4-VALYLOXYBUTYRIC ACID
    Publication number: 20240351975
    Abstract: The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.
    Type: Application
    Filed: May 29, 2024
    Publication date: October 24, 2024
    Inventors: JIA-NING XIANG, HAO-WEI SHIH, XIAOMING WU, XUAN ZHANG, JAMES TIEN
  • Methods of synthesizing 4-valyloxybutyric acid
    Patent number: 12030834
    Abstract: The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.
    Type: Grant
    Filed: July 12, 2023
    Date of Patent: July 9, 2024
    Assignee: XWPHARMA LTD.
    Inventors: Jia-Ning Xiang, Hao-Wei Shih, Xiaoming Wu, Xuan Zhang, James Tien
  • MODIFIED RELEASE COMPOSITIONS OF A GAMMA-HYDROXYBUTYRIC ACID DERIVATIVE
    Publication number: 20240156741
    Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing 4-((L-valyl)oxy)butanoic acid are disclosed. The functional coatings provide for immediate release or modified release of 4-((L-valyl)oxy)butanoic acid. The pharmaceutical granulations can be used in oral pharmaceutical compositions.
    Type: Application
    Filed: January 24, 2024
    Publication date: May 16, 2024
    Inventors: SAMI KARABORNI, DANIEL M. CANAFAX, JIA-NING XIANG, WILLIAM W. XIANG, JAMES TIEN, STEFANIE THIEL, NORBERT POLLINGER, ANNETTE GRAVE
  • CRYSTALLINE 4-((L-VALYL)OXY)BUTANOIC ACID
    Publication number: 20240092727
    Abstract: Crystalline 4-((L-valyl)oxy)butanoic acid, methods of preparing crystalline 4-((L-valyl)oxy)butanoic acid, pharmaceutical compositions of crystalline 4-((L-valyl)oxy)butanoic acid, and methods of treatment using crystalline 4-((L-valyl)oxy)butanoic acid are disclosed.
    Type: Application
    Filed: August 29, 2023
    Publication date: March 21, 2024
    Inventors: JIA-NING XIANG, XUESONG XU, XUAN ZHANG, JAMES TIEN, HAO-WEI SHIH, HSIN-YI HUANG
  • Modified release compositions of a GAMMA-hydroxybutyric acid derivative
    Patent number: 11925710
    Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing 4-((L-valyl)oxy)butanoic acid are disclosed. The functional coatings provide for immediate release or modified release of 4-((L-valyl)oxy)butanoic acid. The pharmaceutical granulations can be used in oral pharmaceutical compositions.
    Type: Grant
    Filed: June 17, 2022
    Date of Patent: March 12, 2024
    Assignee: XWPHARMA LTD.
    Inventors: Sami Karaborni, Daniel M. Canafax, Jia-Ning Xiang, William W. Xiang, James Tien, Stefanie Thiel, Norbert Pollinger, Annette Grave
  • METHODS OF SYNTHESIZING 4-VALYLOXYBUTYRIC ACID
    Publication number: 20230357130
    Abstract: The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.
    Type: Application
    Filed: July 12, 2023
    Publication date: November 9, 2023
    Inventors: JIA-NING XIANG, HAO-WEI SHIH, XIAOMING WU, XUAN ZHANG, JAMES TIEN
  • Methods of synthesizing 4-valyloxybutyric acid
    Patent number: 11746081
    Abstract: The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.
    Type: Grant
    Filed: February 16, 2022
    Date of Patent: September 5, 2023
    Assignee: XWPHARMA LTD.
    Inventors: Jia-Ning Xiang, Hao-Wei Shih, Xiaoming Wu, Xuan Zhang, James Tien
  • MODIFIED RELEASE COMPOSITIONS OF A GAMMA-HYDROXYBUTYRIC ACID DERIVATIVE
    Publication number: 20220323365
    Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing 4-((L-valyl)oxy)butanoic acid are disclosed. The functional coatings provide for immediate release or modified release of 4-((L-valyl)oxy)butanoic acid. The pharmaceutical granulations can be used in oral pharmaceutical compositions.
    Type: Application
    Filed: June 17, 2022
    Publication date: October 13, 2022
    Inventors: SAMI KARABORNI, DANIEL M. CANAFAX, JIA-NING XIANG, WILLIAM W. XIANG, JAMES TIEN, STEFANIE THIEL, NORBERT POLLINGER, ANNETTE GRAVE
  • METHODS OF SYNTHESIZING 4-VALYLOXYBUTYRIC ACID
    Publication number: 20220234994
    Abstract: The present disclosure is directed synthetic methods for the preparation of 4-valyloxybutyric acid. The synthetic methods described herein employ a diverse array of protecting group strategies and reaction conditions. Additionally, the present disclosure is directed to compounds useful as synthetic intermediates in the preparation of 4-valyloxybutyric acid.
    Type: Application
    Filed: February 16, 2022
    Publication date: July 28, 2022
    Inventors: JIA-NING XIANG, HAO-WEI SHIH, XIAOMING WU, XUAN ZHANG, JAMES TIEN
  • Modified release compositions of a gamma-hydroxybutyric acid derivative
    Patent number: 11395801
    Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing 4-((L-valyl)oxy)butanoic acid are disclosed. The functional coatings provide for immediate release or modified release of 4-((L-valyl)oxy)butanoic acid. The pharmaceutical granulations can be used in oral pharmaceutical compositions.
    Type: Grant
    Filed: October 5, 2021
    Date of Patent: July 26, 2022
    Assignee: XWPHARMA LTD.
    Inventors: Sami Karaborni, Daniel M. Canafax, Jia-Ning Xiang, William W. Xiang, James Tien, Stefanie Thiel, Norbert Pollinger, Annette Grave
  • CONTROLLED RELEASE GRANULATIONS OF WATER-SOLUBLE ACTIVE PHARMACEUTICAL INGREDIENTS
    Publication number: 20220183977
    Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing a water-soluble active pharmaceutical ingredient are disclosed. The functional coating provides for immediate release or controlled release of the active pharmaceutical ingredient. The pharmaceutical granulations can be used in oral pharmaceutical compositions.
    Type: Application
    Filed: March 4, 2022
    Publication date: June 16, 2022
    Inventors: SAMI KARABORNI, DANIEL M. CANAFAX, JIA-NING XIANG, WILLIAM W. XIANG, JAMES TIEN, NICOLAS D. KIRKLAND
  • Controlled release granulations of water-soluble active pharmaceutical ingredients
    Patent number: 11304906
    Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing a water-soluble active pharmaceutical ingredient are disclosed. The functional coating provides for immediate release or controlled release of the active pharmaceutical ingredient. The pharmaceutical granulations can be used in oral pharmaceutical compositions.
    Type: Grant
    Filed: June 17, 2021
    Date of Patent: April 19, 2022
    Assignee: XWPHARMA LTD.
    Inventors: Sami Karaborni, Daniel M. Canafax, Jia-Ning Xiang, William W. Xiang, James Tien, Nicolas D. Kirkland
  • MODIFIED RELEASE COMPOSITIONS OF A GAMMA-HYDROXYBUTYRIC ACID DERIVATIVE
    Publication number: 20220105044
    Abstract: Pharmaceutical granulations having a functional coating surrounding a core containing 4-((L-valyl)oxy)butanoic acid are disclosed. The functional coatings provide for immediate release or modified release of 4-((L-valyl)oxy)butanoic acid. The pharmaceutical granulations can be used in oral pharmaceutical compositions.
    Type: Application
    Filed: October 5, 2021
    Publication date: April 7, 2022
    Inventors: SAMI KARABORNI, DANIEL M. CANAFAX, JIA-NING XIANG, WILLIAM W. XIANG, JAMES TIEN, STEFANIE THIEL, NORBERT POLLINGER, ANNETTE GRAVE