Abstract: An example system includes a gantry including a beamline structure configured to direct a particle beam from an output of a particle accelerator toward an irradiation target at a treatment position. The beamline structure includes magnetic bending elements to bend the particle beam along at least part of a length of the beamline structure. A mount, on which at least part of the beamline structure is held, is configured to enable translational movement of at least part of the beamline structure relative to the irradiation target.

Abstract: An example particle therapy system includes a gantry having a beamline structure configured to direct a particle beam that is monoenergetic from an output of a particle accelerator towards an irradiation target, where the beamline structure includes magnetic bending elements to bend the particle beam along a length of the beamline structure; and an energy degrader downstream of the beamline structure relative to the particle accelerator, where the energy degrader is configured and controllable to change an energy of the particle beam prior to at least part of the particle beam reaching the irradiation target.

Abstract: The invention provides methyl-substituted pyridine and pyridazine compounds, derivatives thereof, and methods of their use. The compounds are useful as pharmacological agents to treat a variety of conditions, including various pain states, itch, and cough.

Abstract: Embodiments of the present invention described herein relate to vacuum cleaners. The vacuum cleaners described herein can include a motor, a lid, a collection receptacle, and at least one support member to permit access to the interior of the vacuum cleaner. Also described herein are vacuum cleaners having a motor, a lid, a collection receptacle, and an accessory holder that can be pivotally mounted to the collection receptacle to permit access to the contents thereof.

Abstract: A series of substituted imidazo[1,2-b]pyridazine derivatives as defined herein, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

Abstract: Embodiments of the present invention described herein relate to vacuum cleaners. The vacuum cleaners described herein can include a motor, a lid, a collection receptacle, and at least one support member to permit access to the interior of the vacuum cleaner. Also described herein are vacuum cleaners having a motor, a lid, a collection receptacle, and an accessory holder that can be pivotally mounted to the collection receptacle to permit access to the contents thereof.

Abstract: A simulation workflow manager obtains a set of parameters for simulation of a system and training of a reinforcement learning model for optimizing an application of the system. In response to obtaining the set of parameters, the simulation workflow manager configures a first compute node that includes a training application for training the reinforcement learning model. The simulation workflow manager also configures a second compute note with a simulation application to perform the simulation of the system in a simulation environment. Data is generated through execution of the simulation in the second compute node that is provided to the first compute node to cause the training application to use the data to train the reinforcement learning model.

Abstract: The present invention covers substituted. Pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of general formula (I): in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic diseases, as a sole agent or in combination with other active ingredients.

Abstract: A simulation workflow manager obtains a set of parameters for simulation of a system and training of a reinforcement learning model for optimizing an application of the system. In response to obtaining the set of parameters, the simulation workflow manager configures a first compute node that includes a training application for training the reinforcement learning model. The simulation workflow manager also configures a second compute note with a simulation application to perform the simulation of the system in a simulation environment. Data is generated through execution of the simulation in the second compute node that is provided to the first compute node to cause the training application to use the data to train the reinforcement learning model.

Abstract: Embodiments of the present invention described herein relate to vacuum cleaners. The vacuum cleaners described herein can include a motor, a lid, a collection receptacle, and at least one support member to permit access to the interior of the vacuum cleaner. Also described herein are vacuum cleaners having a motor, a lid, a collection receptacle, and an accessory holder that can be pivotally mounted to the collection receptacle to permit access to the contents thereof.

Abstract: The present invention covers substituted. Pyrazolo-pyrrolo-pyrimidine-dione (PPPD) compounds of general formula (I): in which R1, R2 and R3 are as defined herein, methods of preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of neurogenic diseases, as a sole agent or in combination with other active ingredients.

Abstract: A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

Abstract: An apparatus uses disinfecting ultraviolet light in the C spectrum (UVC) within a housing having an interior chamber. The exterior surfaces of the apparatus are provided in stainless steel suitable for a health care environment. The housing is configured to receive a variety of large devices such as walkers and wheel chairs. Once placed in the interior chamber, first and second offset sanitizing lights are turned on to sanitize the item or items disposed in the interior chamber. The offset lights provide light coverage to both ends of an item such as a wheel chair placed in the interior chamber. The interior of the chamber is lined with reflective, noduled material, to reflect light in a scattered pattern to increase coverage for the item being sanitized. A door closes the interior chamber when the lights are turned on. An interlock is used with the door to turn the lights off when the door is open.

Abstract: The invention relates to 6,5 heterobicyclic ring derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use for the treatment of inflammatory conditions driven by STING activation, such as, but not confined to, SLE and geographic atrophy.

Abstract: A simulation workflow manager obtains a set of parameters for simulation of a system and training of a reinforcement learning model for optimizing an application of the system. In response to obtaining the set of parameters, the simulation workflow manager configures a first compute node that includes a training application for training the reinforcement learning model. The simulation workflow manager also configures a second compute note with a simulation application to perform the simulation of the system in a simulation environment. Data is generated through execution of the simulation in the second compute node that is provided to the first compute node to cause the training application to use the data to train the reinforcement learning model.

Abstract: A series of substituted spirocyclic 2-oxoindoline derivatives, and analogues thereof, being potent modulators of human IL-17 activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including inflammatory and autoimmune disorders.

Abstract: Embodiments of the present invention described herein relate to vacuum cleaners. The vacuum cleaners described herein can include a motor, a lid, a collection receptacle, and at least one support member to permit access to the interior of the vacuum cleaner. Also described herein are vacuum cleaners having a motor, a lid, a collection receptacle, and an accessory holder that can be pivotally mounted to the collection receptacle to permit access to the contents thereof.

Abstract: Embodiments of the present invention described herein relate to vacuum cleaners. The vacuum cleaners described herein can include a motor, a lid, a collection receptacle, and at least one support member to permit access to the interior of the vacuum cleaner. Also described herein are vacuum cleaners having a motor, a lid, a collection receptacle, and an accessory holder that can be pivotally mounted to the collection receptacle to permit access to the contents thereof.

Abstract: Embodiments of the present invention described herein relate to vacuum cleaners. The vacuum cleaners described herein can include a motor, a lid, a collection receptacle, and at least one support member to permit access to the interior of the vacuum cleaner. Also described herein are vacuum cleaners having a motor, a lid, a collection receptacle, and an accessory holder that can be pivotally mounted to the collection receptacle to permit access to the contents thereof.

Abstract: Techniques are disclosed for performing operations in an authentication token or other cryptographic device in a system comprising an authentication server. In one aspect, a code generated by the authentication server is received in the cryptographic device. The code may have associated therewith information specifying at least one operation to be performed by the cryptographic device. The cryptographic device authenticates the code, and responsive to authentication of the code, performs the specified operation. If the code is not authenticated, the operation is not performed. The code may be determined as a function of a one-time password generated by the authentication server. The function may also take as an input an identifier of the operation to be performed.