Abstract: IL-12 variants are provided. Also provided are antibodies that specifically bind to PD1. Also provided are fusion proteins of IL-12 variants and anti-PD1 antibodies. Also provided are uses of these IL-12 variants, anti-PD1 antibodies, fusion proteins, and related compositions and methods.

Abstract: The present disclosure provides human IL-2 variants, recombinant oncolytic viruses comprising the IL-2 variant, compositions comprising the IL-2 variant or recombinant oncolytic virus, and use of the IL-2 variants, recombinant oncolytic virus, or compositions for treating cancer in an individual.

Abstract: The invention relates to alpha conotoxin (?-conotoxin) peptides and methods for their preparation. Also described are pharmaceutical compositions comprising alpha conotoxin (?-conotoxin) peptides and their use in the treatment or prevention of indications 5 associated with nicotinic acetylcholine receptors and/or voltage gated calcium channels.

Abstract: A pre-mix burner apparatus includes a burner having a generally cylindrical burner surface, the burner having a generally circular burner inlet at one end of the burner, the burner inlet having an inlet diameter. A flow distribution member is arranged to distribute flow of fuel and air mixture into the burner. The flow distribution member includes a closed axially central portion configured to block flow of fuel and air mixture axially centrally into the burner. The flow distribution member includes a plurality of vanes extending radially outward from the closed axially central portion. The vanes are configured to generate a swirling flow of fuel and air mixture flowing past the vanes into the burner.

Abstract: The invention relates to alpha conotoxin (?-conotoxin) peptides and methods for their preparation. Also described are pharmaceutical compositions comprising alpha conotoxin (?-conotoxin) peptides and their use in the treatment or prevention of indications 5 associated with nicotinic acetylcholine receptors and/or voltage gated calcium channels.

Abstract: A water heater apparatus includes an elongated radial burner extending along a longitudinal central axis of the apparatus. First and second concentric rows of longitudinally extending fin tubes around the radial burner. The fin tubes may have multiple wiped circumferentially laterally portions allowing close packing of the fin tubes for improved efficiency and reduced footprint.

Abstract: Three dimensional structural frames and enclosures and related methods are disclosed herein. In an example embodiment, an enclosure includes a plurality of three dimensional structural frames and opposing wall portions interconnected by the plurality of three dimensional structural frames, where the wall portions include a plurality of uniform wall sections, where the wall sections include a wall panel portion, a top wall portion, and sidewall portions, where the sidewall portions of the plurality of wall sections are joined to form the wall portions, and where the plurality of three dimensional structural frames are attached to the top wall portions of the wall sections.

Abstract: A flame resistant textile is provided. The textile is a sateen weave fabric containing cellulosic fibers, where the sateen weave fabric has a thickness of at least 19.5 mils, a thickness of at least 25 mils after 3 home washes at 120° F., an air permeability of at least 60 cfm, and a weight of less than about 7 oz/yd2. The sateen weave fabric also contains a treatment, where the treatment contains a tetramethylhydroxy phosphonium salt or its condensate and chemical selected from the group consisting of urea, guanidines, guanyl urea, glycoluril, and polyamines. When the sateen weave fabric to which the treatment has been applied has been heat-cured and oxidized at least a portion of the cellulosic fibers have a pentavalent phosphate compound polymerized therein. The method for producing the flame resistant textile is also provided.

Abstract: A method of initializing an electronic lock in the field includes the steps of providing a unique lock identifier for a lock, providing a unique organization identifier for an organization, generating master encryption keys for the organization derived from the unique organization identifier for that organization, communicating the unique organization identifier and master encryption keys for the organization to a remote mobile device, using the mobile device to remotely generate individual encryption keys for the lock utilizing one of the master encryption keys, the unique organization identifier and the unique lock identifier for the one of the plurality of locks, and using the mobile device to remotely program a manager key to communicate the individual encryption keys to the lock.

Abstract: Three dimensional structural frames and enclosures and related methods are disclosed herein. In an example embodiment, an enclosure includes a plurality of three dimensional structural frames and opposing wall portions interconnected by the plurality of three dimensional structural frames, where the wall portions include a plurality of uniform wall sections, where the wall sections include a wall panel portion, a top wall portion, and sidewall portions, where the sidewall portions of the plurality of wall sections are joined to form the wall portions, and where the plurality of three dimensional structural frames are attached to the top wall portions of the wall sections.

Abstract: Three dimensional structural frames and enclosures and related methods are disclosed herein. In an example embodiment, an enclosure includes a plurality of three dimensional structural frames and opposing wall portions interconnected by the plurality of three dimensional structural frames, where the wall portions include a plurality of uniform wall sections, where the wall sections include a wall panel portion, a top wall portion, and sidewall portions, where the sidewall portions of the plurality of wall sections are joined to form the wall portions, and where the plurality of three dimensional structural frames are attached to the top wall portions of the wall sections.

Abstract: A significantly simplified sight unit for a mortar is provided consisting of a gauge tool for boresight procedures containing a frame with two legs, each containing a level secured to the frame by a securing bracket. A plurality of C-brackets and screw assemblies stabilize and help further secure the levels to the frame.

Abstract: A water heater apparatus includes an elongated radial burner extending along a longitudinal central axis of the apparatus. First and second concentric rows of longitudinally extending fin tubes around the radial burner. The fin tubes may have multiple wiped circumferentially laterally portions allowing close packing of the fin tubes for improved efficiency and reduced footprint.

Abstract: A pre-mix burner apparatus includes a burner having a generally cylindrical burner surface, the burner having a generally circular burner inlet at one end of the burner, the burner inlet having an inlet diameter. A flow distribution member is arranged to distribute flow of fuel and air mixture into the burner. The flow distribution member includes a closed axially central portion configured to block flow of fuel and air mixture axially centrally into the burner. The flow distribution member includes a plurality of vanes extending radially outward from the closed axially central portion. The vanes are configured to generate a swirling flow of fuel and air mixture flowing past the vanes into the burner.

Abstract: Three dimensional structural frames and enclosures and related methods are disclosed herein. In an example embodiment, an enclosure includes a plurality of three dimensional structural frames and opposing wall portions interconnected by the plurality of three dimensional structural frames, where the wall portions include a plurality of uniform wall sections, where the wall sections include a wall panel portion, a top wall portion, and sidewall portions, where the sidewall portions of the plurality of wall sections are joined to form the wall portions, and where the plurality of three dimensional structural frames are attached to the top wall portions of the wall sections.

Abstract: A method of initializing an electronic lock in the field includes the steps of providing a unique lock identifier for a lock, providing a unique organization identifier for an organization, generating master encryption keys for the organization derived from the unique organization identifier for that organization, communicating the unique organization identifier and master encryption keys for the organization to a remote mobile device, using the mobile device to remotely generate individual encryption keys for the lock utilizing one of the master encryption keys, the unique organization identifier and the unique lock identifier for the one of the plurality of locks, and using the mobile device to remotely program a manager key to communicate the individual encryption keys to the lock.

Abstract: A method for treating a volume of porous contaminated material is described. A combustible mixture (24) comprising a porous matrix and a distributed combustible contaminant is conveyed to a reaction vessel (12) having an ignition system (16). The ignition system is activated to initiate a smoldering combustion process in the reaction vessel and an oxidizer is distributed into the reaction vessel to sustain the smoldering combustion process. The porous matrix may comprise drill cuttings (324) with residual drilling fluid.

Abstract: A boresight verification device (BVD) comprised of a circular housing with a rear portion of smaller diameter and a front portion of larger diameter. The front portion securely holds a level. The circular housing also contains a plurality of spring plungers which grip the inside of a muzzle when BVD is inserted into a muzzle for use. A tooling ball provides a stable reference point.

Abstract: A method for treating a volume of porous contaminated material is described. A combustible mixture (24) comprising a porous matrix and a distributed combustible contaminant is conveyed to a reaction vessel (12) having an ignition system (16). The ignition system is activated to initiate a smoldering combustion process in the reaction vessel and an oxidizer is distributed into the reaction vessel to sustain the smoldering combustion process. The porous matrix may comprise drill cuttings (324) with residual drilling fluid.