Abstract: The present invention features an optical detection system for SARS-CoV-2 or other pathogens, which includes a specialty mask. The specialty mask incorporates a SERS nanopatch for accumulating pathogenic particles from a wearers breath. When the SERS nanopatch receives incident NIR light, backscattered light from the SERS nanopatch is detected by a receiver and analyzed for a Raman spectral shift. Detection of the Raman spectral signature from the SERS nanopatch allows for determination if SARS-CoV-2 or another pathogen is present. In addition to the mask with a nanostructured surface for collecting pathogenic material, the system includes a laser source directed at the nanostructured surface, a detection system to collect backscattered light, a spectral analysis system to detect Raman shifted light, and an analysis system for determining if SARS-CoV-2 or another pathogen is present. AI image processing may be used to steer the laser beam safely to the nanopatch, avoiding eye contact.