Abstract: An imaging apparatus may be used for histological and/or molecular imaging of a tissue sample. An imaging apparatus may include one or more light sources that generate one or more excitation beams directed toward an excitation location being focused on the sample to generate signals in the sample and one or more interrogation beams directed toward a detection location such that a portion of the one or more interrogation beams returning from the sample is indicative of at least some of the generated signals. An imaging apparatus may include a photodetector configured to detect radiative signals from the sample. An imaging apparatus may generate an image of the sample using only pressure (photoacoustic) signals, only temperature (photothermal) signals, and/or both photoacoustic and photothermal signals from the generated signals.

Abstract: An imaging apparatus may be used for histological and/or molecular imaging of a tissue sample. An imaging apparatus may include one or more light sources that generate one or more excitation beams directed toward an excitation location being focused on the sample to generate signals in the sample and one or more interrogation beams directed toward a detection location such that a portion of the one or more interrogation beams returning from the sample is indicative of at least some of the generated signals. An imaging apparatus may include a photodetector configured to detect radiative signals from the sample. An imaging apparatus may generate an image of the sample using only pressure (photoacoustic) signals, only temperature (photothermal) signals, and/or both photoacoustic and photothermal signals from the generated signals.

Abstract: An imaging apparatus may be used for histological and/or molecular imaging of a tissue sample. An imaging apparatus may include one or more light sources that generate one or more excitation beams directed toward an excitation location being focused on the sample to generate signals in the sample and one or more interrogation beams directed toward a detection location such that a portion of the one or more interrogation beams returning from the sample is indicative of at least some of the generated signals. An imaging apparatus may include a photodetector configured to detect radiative signals from the sample. An imaging apparatus may generate an image of the sample using only pressure (photoacoustic) signals, only temperature (photothermal) signals, and/or both photoacoustic and photothermal signals from the generated signals.

Abstract: A method of visualizing details in a sample may comprise generating radiative and non-radiative signals in the sample at an excitation location using an excitation beam, interrogating the sample with an interrogation beam directed toward the excitation location of the sample, and detecting light from the sample. The excitation beam may be focused below a surface of the sample. The interrogation beam may be focused below the surface of the sample. The detected light may include a portion of the interrogation beam returning from the sample. The detected light may be indicative of the generated radiative an non-radiative signals.