Patents by Inventor James V. Earley

James V. Earley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds useful as dual antagonists of platelet activating factor and leukotriene D.sub.4
    Patent number: 5428004
    Abstract: The invention relates to compounds of the formula ##STR1## wherein R.sub.1 is OR.sub.6 or NHR.sub.7, R.sub.6 and R.sub.7, which may be, the same or different, are hydrogen, lower alkyl, lower alkenyl, cycloalkyl having between 3 to 6 carbon atoms or phenyl, R.sub.2 is lower alkyl, lower alkoxy or trifluoromethyl, R.sub.3 and R.sub.4 independently, are hydrogen, chlorine, fluorine, lower alkyl or lower alkoxy, and R.sub.5 is lower alkyl or cycloalkyl having between 3 to 6 carbon atoms, and when at least one asymetric carbon is present, enantiomers, and racemates thereof, and pharmaceutically acceptable salts thereof.The compounds of formula I and pharmaceutically acceptable salts thereof are useful as bronchopulmonary agents for example in the relief of asthma and allergic reactions.In another aspect, the invention relates to pharmaceutical compositions, methods of using the compound of formula I and intermediates.
    Type: Grant
    Filed: December 8, 1993
    Date of Patent: June 27, 1995
    Assignee: Hoffmann-La Roche Inc.
    Inventors: James V. Earley, Norman W. Gilman, Perry Rosen
  • Compounds useful as dual antagonists of platelet activating factor and leukotriene D4
    Patent number: 5302590
    Abstract: The invention relates to compounds of the formula ##STR1## wherein R.sub.1 is OR.sub.6 or NHR.sub.7, R.sub.6 and R.sub.7, which may be, the same or different, are hydrogen, lower alkyl, lower alkenyl, cycloalkyl having between 3 to 6 carbon atoms or phenyl, R.sub.2 is lower alkyl, lower alkoxy or trifluoromethyl, R.sub.3 and R.sub.4, independently, are hydrogen, chlorine, fluorine, lower alkyl or lower alkoxy, and R.sub.5 is lower alkyl or cycloalkyl having between 3 to 6 carbon atoms, and when at least one asymetric carbon is present, enantiomers, and racemates thereof, and pharmaceutically acceptable salts thereof.The compounds of formula I and pharmaceutically acceptable salts thereof are useful as bronchopulmonary agents for example in the relief of asthma and allergic reactions.In another aspect, the invention relates to pharmaceutical compositions, methods of using the compound of formula I and intermediates.
    Type: Grant
    Filed: December 18, 1992
    Date of Patent: April 12, 1994
    Assignee: Hoffmann-La Roche Inc.
    Inventors: James V. Earley, Norman W. Gilman, Perry Rosen
  • Substituted amino-benzodiazepines having anitviral activity
    Patent number: 5141735
    Abstract: Novel substituted 2-amino-5-(1H-pyrrol-2-yl)-3H-1,4-benzodiazepines and compositions containing same for treatment and prophylaxis of viral infections, including HIV infections.
    Type: Grant
    Filed: June 18, 1990
    Date of Patent: August 25, 1992
    Assignee: Hoffman-La Roche, Inc.
    Inventors: Anne R. Bellemin, James V. Earley, Ming-Chu Hsu, Steve Yik-Kai Tam
  • Benzodiazepine derivatives
    Patent number: 4777169
    Abstract: Benzodiazepine derivatives useful in immunoassays for benzodiazepines.
    Type: Grant
    Filed: November 6, 1987
    Date of Patent: October 11, 1988
    Assignee: Hoffmann-La Roche Inc.
    Inventors: James V. Earley, Norman W. Gilman