Abstract: The present disclosure pertains to techniques that leverage machine learning models to identify tumor-specific mutations through an integrated analysis of next generation sequencing data. In a particular aspect, a computer-implemented method is provided that includes generating sequence reads from one or more samples collected from the same patient, generating variant call files by analyzing the sequence reads corresponding respectively to the one or more samples, comparing variant call files to generate a list of candidate somatic variants, generating, by a classification machine learning model, scores for each of the candidate somatic variants in the list of candidate somatic variants, where the scores are generated based on a plurality of classifications generated by the classification machine learning model, determining, based on the scores, a ctDNA status for the patient, where the ctDNA status is either positive or negative, and generating a report that provides the ctDNA status for the patient.

Abstract: The present invention is directed to the identification of markers that can be used to determine the sensitivity of cancer cells to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. Nucleic acid arrays were used to determine the level of expression of sequences (genes) found in 60 different solid tumor cancer cell lines selected from the NCI 60 cancer cell line series. Expression analysis was used to identify markers associated with sensitivity to certain chemotherapeutic agents.

Abstract: The present invention is directed to the identification of markers that can be used to determine the sensitivity of cancer cells to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. Nucleic acid arrays were used to determine the level of expression of sequences (genes) found in 60 different solid tumor cancer cell lines selected from the NCI 60 cancer cell line series. Expression analysis was used to identify markers associated with sensitivity to certain chemotherapeutic agents.

Abstract: The present invention is directed to the identification of markers that can be used to determine the sensitivity of cancer cells to a therapeutic agent. The present invention is also directed to the identification of therapeutic targets. Nucleic acid arrays were used to determine the level of expression of sequences (genes) found in 60 different solid tumor cancer cell lines selected from the NCI 60 cancer cell line series. Expression analysis was used to identify markers associated with sensitivity to certain chemotherapeutic agents.

Abstract: An apparatus for magnetic annealing of amorphous metal alloy cores. The apparatus includes a fluidized bed for heating the core, a conveyor for transporting the core and immersing the core in the fluidized bed and at least one winding for applying a magnetic field to the core. The apparatus can include a chill bath and/or a second fluidized bed for cooling the core. A chamber can be provided between the two fluidized beds for slow cooling the core by convection and radiation prior to cooling the core at a faster rate in the second fluidized bed.

Abstract: An apparatus and method for structurally restraining and reinforcing an amorphous metal core of an electrical transformer employs an adhesive bonding agent applied to the lamination edges and protective layers of the core followed by adhesion of a woven fabric thereto to form a highly permeable oil/air interface with the lamination edges of the amorphous material, while providing an effective chip containment system thereto. A temporary guide sleeve aids the core and coil lacing operation. A method for breaking performance inhibiting interlaminar bonds between the amorphous layers of the core.

Abstract: A method of heat treating an amorphous metal alloy by immersing the alloy in a fluidized bed to heat the alloy to a temperature below its recrystallization temperature. The alloy is maintained in the fluidized bed for a time sufficient to reduce internal stresses While minimizing crystal growth and nucleation of crystallites in the alloy. Then, the alloy is removed from the fluidized bed and cooled. A magnetic field can be applied to the alloy before, during or after heating the alloy in the fluidized bed. The magnetic field is applied for a time sufficient to achieve substantial magnetic domain alignment while minimizing crystal growth and nucleation of crystallites in the alloy. The cooling step is effective to maintain the magnetic domain alignment in the alloy. The cooling step can be performed with a chill bath or a fluidized bed which is cooled by a circulating gas such as nitrogen or air. The alloy can be slowly cooled by convection and radiation after it is removed from the first fluidized bed.

Abstract: An apparatus and method for structurally restraining and reinforcing an amorphous metal core of an electrical transformer employs an adhesive bonding agent applied to the lamination edges and protective layers of the core followed by adhesion of a woven fabric thereto to form a highly permeable oil/air interface with the lamination edges of the amorphous material, while providing an effective chip containment system thereto. A temporary guide sleeve aids the core and coil lacing operation. A method for breaking performance inhibiting interlaminar bonds between the amorphous layers of the core is also disclosed.

Abstract: A transformer core of non-circular cross-section, preferably rectilinear, is formed by successively wrapping individual packets of core strips around a stationary mandrel of non-circular cross-section. Each packet is wrapped by a pair of yieldably biased rollers which follow the contour of the mandrel. As the packet is being wrapped, pressure pads are extended to hold the packet against the mandrel. The pressure pads are momentarily retracted to accommodate return movement of the roller wipers to receive a subsequent packet. The ends of the packet form a joint at the top of the mandrel. The positions of successive packets can be changed to vary the location of the joint in order to form a desired joint pattern.

Abstract: A method of heat treating an amorphous metal alloy by immersing the alloy in a fluidized bed to heat the alloy to a temperature below its recrystallization temperature. The alloy is maintained in the fluidized bed for a time sufficient to reduce internal stresses while minimizing crystal growth and nucleation of crystallites in the alloy. Then, the alloy is removed from the fluidized bed and cooled. A magnetic field can be applied to the alloy before, during or after heating the alloy in the fluidized bed. The magnetic field is applied for a time sufficient to achieve substantial magnetic domain alignment while minimizing crystal growth and nucleation of crystallites in the alloy. The cooling step is effective to maintain the magnetic domain alignment in the alloy. The cooling step can be performed with a chill bath or a fluidized bed which is cooled by a circulating gas such as nitrogen or air. The alloy can be slowly cooled by convection and radiation after it is removed from the first fluidized bed.

Abstract: An apparatus for receiving electronic signals and embossing modulated grooves on a carrier medium as a function of the received signals, includes a support for supporting an embossing assembly and a carrier medium in spaced relationship therewith, as well as apparatus for causing relative motion between the carrier medium and the embossing assembly. In accordance with the invention there is provided a wafer of piezoelectric material affixed to the mount, the wafer having electrodes for application of the electronic signals. Further provided is a horn-shaped stylus member having a relatively blunt end affixed to one side of the wafer and tapering to a relatively pointy stylus end, the stylus end being positionable in contact with the medium. The horn-shaped member serves to match the mechanical impedence as between the wafer and the carrier. A dummy horn on the other side of the wafer adds a vibration reducing load to the structure.