Patents by Inventor James Velier

James Velier has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Huntingtin-related therapeutics and bioassay
    Patent number: 6602673
    Abstract: A method of identifying a compound useful in the treatment of a disease characterized by the presence of mutant huntingtin by: (a) providing a cell which expresses mutant huntingtin; (b) contacting the cell with a test compound; and (c) determining whether the level of clathrin-mediated endocytosis is increased in the presence of the test compound, compared to the level in the absence of the test compound. An increase in clathrin-mediated endocytosis is an indication that the test compound is useful in treating the disease.
    Type: Grant
    Filed: November 14, 1997
    Date of Patent: August 5, 2003
    Assignees: University of Massachusetts, The General Hospital Corporation
    Inventors: Marian DiFiglia, Neil Aronin, James Velier
  • HUNTINGTIN-RELATED THERAPEUTICS AND BIOASSAY
    Publication number: 20010007753
    Abstract: A method of identifying a compound useful in the treatment of a disease characterized by the presence of mutant huntingtin by: (a) providing a cell which expresses mutant huntingtin; (b) contacting the cell with a test compound; and (c) determining whether the level of clathrin-mediated endocytosis is increased in the presence of the test compound, compared to the level in the absence of the test compound. An increase in clathrin-mediated endocytosis is an indication that the test compound is useful in treating the disease.
    Type: Application
    Filed: November 14, 1997
    Publication date: July 12, 2001
    Applicant: UNIVERSITY OF MASSACHUSETTS
    Inventors: MARIAN DIFIGLIA, NEIL ARONIN, JAMES VELIER