Abstract: A device and method useful for guiding insertion of a surgical device with image guided surgery. The device includes a base that may be connected to a fixation device to hold the device in place, and a guide for the surgical device. The guide is connected to the base by a semispherical ball joint, which allows the trajectory of the guide to be adjusted. The device includes an adjustable depth stop that controls the distance the surgical device is inserted into the patient. A positional indicator is attached to the depth stop. An insertion indicator signals when the depth stop is set so as to limit the insertion distance to that necessary to treat the target tissue within the patient.