Patents by Inventor James W. Bloom

James W. Bloom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Removal of protein A from antibody preparations
    Patent number: 5115101
    Abstract: Antibody preparation purified using immobilized protein A and yet substantially free of protein A that may have solubilized during the purificaiton process. The antibodies include less than 15 ng protein A per mg of antibody, preferably less than 1 ng/mg. Low protein A content is obtained by first contacting the antibodies and solubilized protein A with an ion exchange resin under conditions to adsorb both. The antibodies and protein A are then sequentially eluted under conditions of increasing ionic strength.
    Type: Grant
    Filed: June 26, 1991
    Date of Patent: May 19, 1992
    Assignee: Miles Inc.
    Inventors: James W. Bloom, Melvin F. Wong, Gautam Mitra
  • Removal of protein A from antibody preparations
    Patent number: 4983722
    Abstract: Protein A is selectively isolated from an antibody--Protein A mixture by exposing the mixture to an anion exchange material under conditions sufficient to adsorb both components and then sequentially eluting the antibodies and protein A under conditions of increasing ionic strength. Resulting antibody preparations have less than about 15 ng of Protein A per mg of antibody.
    Type: Grant
    Filed: June 8, 1988
    Date of Patent: January 8, 1991
    Assignee: Miles Inc.
    Inventors: James W. Bloom, Melvin F. Wong, Gautam Mitra
  • Warm ethanol method for preparation of low fibrinogen antihemophilic factor
    Patent number: 4478825
    Abstract: Antihemophilic factor (AHF), a blood protein component necessary for clotting of normal whole blood, is extracted and concentrated from a cryoprecipitate suspension containing AHF and fibrinogen as its principal components by: selectively precipitating fibrinogen from a water-ethanol solution and removing the ethanol therefrom.
    Type: Grant
    Filed: October 14, 1983
    Date of Patent: October 23, 1984
    Assignee: Armour Pharmaceutical Company
    Inventor: James W. Bloom